Navigation Links
Blood protein may hold key to stopping tumor growth in cancer patients
Date:3/31/2009

WINSTON-SALEM, N.C. A recent discovery by researchers at Wake Forest University School of Medicine could clear the way for a new drug that inhibits tumor growth in cancer patients and could potentially help in the healing of wounds.

The discovery stems from a study, recently published in the Proceedings of the National Academy of Sciences of the United States of America, in which researchers looked at angiogenesis the body's formation of new blood vessels from existing blood vessels and how some blood proteins are involved in that process and affect blood vessel growth.

Researchers found that a protein called ferritin binds to and cripples the ability of another blood protein, called HKa, to shut down blood vessel growth. Because new blood vessels supply a steady stream of nutrients and oxygen that are essential for tumor growth, researchers found that the binding of the two proteins actually assists in new blood vessel formation by removing HKa's influence and therefore promotes tumor growth.

The finding led researchers to the hypothesis that if they can somehow prevent the binding of ferritin and HKa, it will allow HKa to prevent new blood vessel growth and therefore block the growth of tumors.

The finding also has possible implications for wound care. In order to heal, wounds need blood vessel growth. It is therefore possible that by increasing the binding of ferritin to HKa, one could increase the rate at which a serious wound heals.

"It's been known for a long time that levels of ferritin are increased in people with tumors, but it's never been understood why that happens," said Suzy V. Torti, Ph.D., the study's lead investigator, an associate professor of biochemistry and an expert in iron biology at the School of Medicine. "Ferritin appears to play an important role in blood vessel formation. Further, the interaction between ferritin and HKa may represent a new area of interest for possible drug
'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Effort Could Lead to Blood Tests for Heart Problems
2. Blood test for brain injuries gains momentum
3. After heart attack, bone marrow stem cells increase blood flow within heart
4. Statin Might Help Fight Blood Clots in Veins
5. Video: CRESTOR(R) Reduced Risk of Blood Clots in the Veins
6. LegalView Informs Baxter Heparin Patients of New Testing Standards for Blood Thinner Following Deaths From Previous Contamination
7. Kidney Ailments May Rise Along With Blood Pressure
8. Cord Blood America Applauds Congressional Effort Supporting Cord Blood Storage
9. Cord Blood Registry Supports Family Cord Blood Banking Act
10. Researchers decipher blood stem cell attachment, communication
11. Cord Blood America Announces Results of Shareholder Special Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2013)... New York (PRWEB) May 24, 2013 Let’s ... teeth. It is not uncommon for the majority of people ... Whether it is due to a coffee addiction or simply ... why whitening procedures are so popular. , Herald ... new and very effective whitening system: Venus White Max. ...
(Date:5/24/2013)... failed to replicate what appeared to be breakthrough results ... were published last year in the journal Science ... suggested that the drug bexarotene (marketed as Targretin) could ... a pathological hallmark of Alzheimer,s disease in ... the 2012 report, drug treatment quickly removed most of ...
(Date:5/24/2013)... Area homeowners dreaming about owning a hot ... to choose from at factory-direct pricing during the Jacuzzi ... takes place at Emerald Pool and Patio in ... the industry's leading hot tub brand, scheduled the event as ... event will feature popular hot tub models at up to ...
(Date:5/24/2013)... May 24, 2013 Amirsys today announces ... new enhancements for instructors and students. Instructors can use ... through personalize learning plan templates, targeted reading assignments, and ... 500 new assessment questions, 5,000 searchable anatomy glossary terms, ... AnatomyOne 2.0 is the first gross anatomy ...
(Date:5/24/2013)... 24, 2013 The nation’s first trial ... Surgical Inc.’s da Vinci Surgical System concluded yesterday, Bernstein ... Washington State Court jury ruled in a 10-to-2 decision ... surgeon who performed a da Vinci prostatectomy on a ... family had alleged in their lawsuit that the da ...
Breaking Medicine News(10 mins):Health News:Herald Square Dental Introduces New In-office Whitening System: Venus White Max 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 2Health News:Multiple research teams unable to confirm high-profile Alzheimer's study 3Health News:Truckload of Jacuzzi® Hot Tubs Rolls into Bend, Oregon on May 24, 2013 for Sales Event 2Health News:Amirsys AnatomyOne 2.0 Delivers Personalized Learning Plans 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on Verdict in Nation’s First Trial Involving Alleged Da Vinci Complications 2Health News:Da Vinci Robot Lawsuit News: Bernstein Liebhard LLP Comments on Verdict in Nation’s First Trial Involving Alleged Da Vinci Complications 3
... youth are engaging in sexual intercourse as early as age ... of Texas School of Public Health. , Results from ... Journal of School Health . , Christine Markham, Ph.D., ... Public Health, and colleagues examined sexual risk behaviors among middle ...
... Individuals How Much They Will Pay for Treatment ... Their HealthcareANN ARBOR, Mich., April 8 As ... its cost, employers and health insurers need better ... well-informed decisions about their health and use of ...
... April 8 While Wisconsin legislators brainstorm ways ... the state, a private business continues to find ... dangers of alcohol misuse and abuse. Innocorp President ... of Mothers Against Drunk Driving, Mr. Glynn Birch, ...
... hope. PHILADELPHIA, April 8 Kyle,s Treehouse -- ... new initiative for Autism Awareness Month: Autism151, ... focuses on the positive side of the autism experience by ... strength, inspiration and success with one another, giving them even ...
... will provide state employees with health and wellness resources ... HealthFitness (NYSE Amex: FIT ) today ... develop and administer a comprehensive health management program for ... http://www.newscom.com/cgi-bin/prnh/20090122/CG61641LOGO ) , , Neb. Gov. Dave ...
... Increased Tax Would Raise Critical Funds for State Tobacco ... tobacco products - including spit and chew tobacco and ... and should be taxed at the same rate as ... launched today by a coalition of public health ...
Cached Medicine News:Health News:Middle school youth as young as 12 engaging in risky sexual activity 2Health News:HealthEquity, a Leading Healthcare Account Administrator, Licenses Thomson Reuters Information Solutions to Help People Make Better Healthcare Decisions 2Health News:HealthEquity, a Leading Healthcare Account Administrator, Licenses Thomson Reuters Information Solutions to Help People Make Better Healthcare Decisions 3Health News:Former MADD National President Joins Innocorp, ltd. 2Health News:Kyle's Treehouse Launches Autism151.com for Autism Awareness Month 2Health News:HealthFitness Announces New Employee Health Partnership With State of Nebraska 2Health News:New Ohio Ad Campaign Calls for Taxing All Tobacco Products at Same Rate 2
(Date:5/24/2013)... N.C. , May 24, 2013  Regulatory ... the forefront of many organizations, priority list. ... medical device sectors understand a strong Medical ... challenges in clinical development, market education , ... to create a vital bridge between an organization ...
(Date:5/24/2013)... N.J. , May 24, 2013  BD (Becton, Dickinson ... medical technology company, announced today that it will present at ... on Thursday, May 30, 2013, at 10:40 a.m. (ET). ... accessed from the BD corporate website at www.bd.com/investors ... 2013.    About BD BD is ...
(Date:5/24/2013)... 2013 /PRNewswire-iReach/ -- Phoenix Houses of California ... organization, is hosting its tenth annual "Triumph For Teens" ... 6, 2013.  More than 300 people are expected to ... residential treatment centers, family therapy, and prevention programs of ... have positive influences on the health and welfare of our ...
Breaking Medicine Technology:Building Medical Affairs Capabilities to Ensure Organizational Success across Key Operational Areas 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 2Phoenix House Honors Allergan Chairman David Pyott And Legendary Sports Agent And Humanitarian, Leigh Steinberg 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: