Navigation Links
Blood protein may hold key to stopping tumor growth in cancer patients
Date:3/31/2009

WINSTON-SALEM, N.C. A recent discovery by researchers at Wake Forest University School of Medicine could clear the way for a new drug that inhibits tumor growth in cancer patients and could potentially help in the healing of wounds.

The discovery stems from a study, recently published in the Proceedings of the National Academy of Sciences of the United States of America, in which researchers looked at angiogenesis the body's formation of new blood vessels from existing blood vessels and how some blood proteins are involved in that process and affect blood vessel growth.

Researchers found that a protein called ferritin binds to and cripples the ability of another blood protein, called HKa, to shut down blood vessel growth. Because new blood vessels supply a steady stream of nutrients and oxygen that are essential for tumor growth, researchers found that the binding of the two proteins actually assists in new blood vessel formation by removing HKa's influence and therefore promotes tumor growth.

The finding led researchers to the hypothesis that if they can somehow prevent the binding of ferritin and HKa, it will allow HKa to prevent new blood vessel growth and therefore block the growth of tumors.

The finding also has possible implications for wound care. In order to heal, wounds need blood vessel growth. It is therefore possible that by increasing the binding of ferritin to HKa, one could increase the rate at which a serious wound heals.

"It's been known for a long time that levels of ferritin are increased in people with tumors, but it's never been understood why that happens," said Suzy V. Torti, Ph.D., the study's lead investigator, an associate professor of biochemistry and an expert in iron biology at the School of Medicine. "Ferritin appears to play an important role in blood vessel formation. Further, the interaction between ferritin and HKa may represent a new area of interest for possible drug
'/>"/>

Contact: Jessica Guenzel
jguenzel@wfubmc.edu
336-716-3487
Wake Forest University Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Effort Could Lead to Blood Tests for Heart Problems
2. Blood test for brain injuries gains momentum
3. After heart attack, bone marrow stem cells increase blood flow within heart
4. Statin Might Help Fight Blood Clots in Veins
5. Video: CRESTOR(R) Reduced Risk of Blood Clots in the Veins
6. LegalView Informs Baxter Heparin Patients of New Testing Standards for Blood Thinner Following Deaths From Previous Contamination
7. Kidney Ailments May Rise Along With Blood Pressure
8. Cord Blood America Applauds Congressional Effort Supporting Cord Blood Storage
9. Cord Blood Registry Supports Family Cord Blood Banking Act
10. Researchers decipher blood stem cell attachment, communication
11. Cord Blood America Announces Results of Shareholder Special Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... News) -- Adults with dyslexia are more likely to ... teenagers than people who don,t have the learning disorder, ... affects up to 10 percent of people, causes problems ... of adults with this condition said they suffered physical ... those without dyslexia. "Even after accounting for age, ...
(Date:7/10/2014)... Kristen Fischer HealthDay Reporter ... may help ease the hot flashes that often accompany menopause, ... more than 50 percent of menopausal women, said Dr. Taraneh ... science at the Icahn School of Medicine at Mount Sinai ... experience more than 10 hot flashes a day, and she ...
(Date:7/10/2014)... Dennis Thompson HealthDay Reporter ... the Twitter wars that break out regularly between outspoken celebrities ... for your own relationship, a new study suggests. High ... couple, even if the couple is in a long-term relationship, ... users. In turn, that friction can lead to cheating ...
(Date:7/10/2014)... that the "Mississippi Baby," believed to have been functionally ... detectable levels of the virus, the Elizabeth Glaser Pediatric ... remains hopeful that the scientific breakthrough that allowed the ... two years will continue to help researchers understand how ... , "Although we had high hopes that the child ...
(Date:7/10/2014)... than 200 experts on aggression, who research issues ranging ... the 21st World Meeting of the International Society for ... July 15-19. , Georgia State University is hosting the ... on alternating continents. , "We are excited to be ... countries, which will help produce fresh ideas about the ...
Breaking Medicine News(10 mins):Health News:Researchers See Link Between Dyslexia, Abuse 2Health News:Losing Weight May Ease Hot Flashes, Study Finds 2Health News:Losing Weight May Ease Hot Flashes, Study Finds 3Health News:Are You Tweeting Your Marriage Away? 2Health News:Are You Tweeting Your Marriage Away? 3Health News:Despite setback, 'Mississippi Baby' represents significant breakthrough in effort to end AIDS 2Health News:Georgia State hosts national conference on aggression 2Health News:Georgia State hosts national conference on aggression 3
... OXFORD, England, July 13 International medical,communications ... the Year at the Communique Awards in London ... by an independent panel of,communications experts, who assess ... for healthcare clients, along with business strategy,client retention, ...
... Gentiva Health Services, Inc. (Nasdaq: GTIV ), a ... scheduled a conference call and web cast on Thursday, July 30, 2009, ... ended June 28, 2009. Gentiva plans to issue its financial news release ... , The conference call is open to investment analysts ...
... July 13 Sunesis Pharmaceuticals, Inc. (Nasdaq: ... and commercialization of new oncology therapeutics for the treatment ... has received a $1.5 million milestone payment from Biogen ... of a Raf kinase inhibitor development candidate for the ...
... New data pooled from four large, "real world" ... VIII (rFVIII-FS) reduced bleeding and provided data regarding ... mild-to-severe hemophilia A. Additionally, rates of inhibitor formation ... untreated patients. The data were presented at the ...
... , SUNNYVALE, Calif., July 13 Cepheid (Nasdaq: CPHD ... & Drug Administration (FDA) to market its Xpert(R) C. difficile ... of the bacterium that causes Clostridium difficile infection (CDI). ... for CDI to deliver both rapid turnaround and a high degree ...
... , PORT WASHINGTON, N.Y., July 13 ... of the American Medical Association has granted a CPT Category ... (TM) (MCG) system. MCG is the World,s first Internet based, ... for interactive online diagnosis. The MCG is intended as ...
Cached Medicine News:Health News:Gentiva(R) Health Services Schedules Second Quarter Earnings Call and Web Cast for Thursday, July 30, 2009 2Health News:Gentiva(R) Health Services Schedules Second Quarter Earnings Call and Web Cast for Thursday, July 30, 2009 3Health News:Gentiva(R) Health Services Schedules Second Quarter Earnings Call and Web Cast for Thursday, July 30, 2009 4Health News:Sunesis Pharmaceuticals Receives Milestone Payment From Biogen Idec 2Health News:Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII 2Health News:Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII 3Health News:Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII 4Health News:Analysis of Four Large Post-Marketing Surveillance Studies Describe Clinical Effects of Sucrose-Formulated Recombinant Factor VIII 5Health News:Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection 2Health News:Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection 3Health News:Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection 4Health News:Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection 5Health News:AMA Grants New Category III CPT Code to Premier Heart's Multifunction CardioGram(TM) (MCG) 2
(Date:1/15/2014)... Mich. , Jan. 15, 2014 As health officials ... flu virus, select Meijer pharmacies in Michigan ... throat to eligible patients, enabling Meijer pharmacists to administer tests ... protocol set by a physician participating in the study. ...
(Date:1/15/2014)... 2014 Massachusetts General Hospital (MGH), the Broad ... announced today that they have launched a strategic ... targets and develop novel therapies for inflammatory bowel ... worldwide. The MGH-Broad-Amgen collaboration brings together scientists with ...
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, suppliers and distributors ... able to protect their most important business assets, ... ) Because of the highly-competitive ... remains one of the most litigious industry sectors ...
Breaking Medicine Technology:Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Intellectual Property Insurance for Medical-related Products and Services 2
... Calif., Jan. 28 Impact Medical Solutions, Inc. (OTC ... that Mr. Mark A. Billings has joined the Company,s ... Partner at Atwater Financial Group Inc., a Montreal-based financial ... small-cap companies. He is also the President and ...
... ticker symbol ,CDXP.OB, LA JOLLA, Calif., Jan. 28 ... that it has completed a corporate name change to ... change, the Over-the-Counter Bulletin Board will trade the Company,s ... Kuo, M.D., Cordex,s Chief Executive Officer commented, "We are ...
Cached Medicine Technology:Impact Medical Solutions Announces Appointment of New Director and Corporate Update 2Impact Medical Solutions Announces Appointment of New Director and Corporate Update 3Duska Therapeutics Completes Corporate Name Change to Cordex Pharma 2Duska Therapeutics Completes Corporate Name Change to Cordex Pharma 3
... provided by a cool-running, energy efficient LEDs ... you need to see without affecting the ... they are maintenance free so you'll never ... Phoroptor comes with a limited lifetime warranty, ...
... The Reichert CT200 Tonometer ... the XCEL 250 and XCEL ... also compatible with other Zeiss-style ... mounted on the top of ...
10 (mm) smooth platform; Serrated handle in stainless steel....
Compatible with the Volcano Therapeutics Trak Back II Disposable Catheter Pullback Device,and the Volcano Therapeutics In-Vision Imaging System....
Medicine Products: