Navigation Links
Blood product sterilization taken too far?
Date:6/12/2014

Certain processes used to sterilize blood products could potentially cause serious health issues in transfusion recipients, according to an international study published in the journal Platelets and led by Dr. Patrick Provost of Universit Laval's Faculty of Medicine and the CHU de Qubec Research Center. These processes purportedly alter the blood platelets to the extent of preventing them from carrying out their functions correctly and may be the cause of hemorrhages observed in patients having received treated blood.

The function of platelets goes far beyond their role in blood coagulation and wound healing. They contain up to a third of the human genome in the form of ribonucleic acid (RNA), allowing them to synthesize over 1,000 proteins essential to the normal functioning of the human body.

The presence of this genetic material explains why platelets are affected by pathogen reduction treatments. "The processes that are used target the genetic material of pathogenic organisms," explains Patrick Provost. "They were developed more than 20 years ago, before we understood the importance of the genetic material contained in platelets."

Dr. Provost and his colleagues discovered that these treatments activate blood platelets, triggering the release of RNA. "The platelets end up depleted of RNA so, once transfused, they're unable to do what they normally would," says the researcher.

The treatments are already on the market in some European countries, notably Switzerland, France, and Germany. Manufacturers are trying to get approval in other countries, including Canada and the United States. Professor Provost regrets the dearth of independent studies that have focused on the safety of the processes and hopes regulatory authorities such as Health Canada and the U.S. Food and Drug Administration will take these results into consideration. "In light of what we have demonstrated, the potentially harmful effects of these treatments should be carefully evaluated in the countries where they are not yet approved. It should also be re-evaluated in those countries where they are," concludes Provost.


'/>"/>
Contact: Jean-François Huppé
jean-francois.huppe@dc.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Related medicine news :

1. Mount Sinai researchers identify protein that keeps blood stem cells healthy as they age
2. Bloodstream infections reduced through better central line care at three hospitals
3. Mayo Clinic moves small-molecule drugs through blood-brain barrier
4. Experts recommend blood, urine testing to diagnose rare adrenal tumors
5. CPAP rapidly improves blood pressure and arterial tone in adults with sleep apnea
6. Surgeons report fewer postoperative blood clots using risk-based preventive measures
7. Why inflammation leads to a leaky blood-brain barrier: MicroRNA-155
8. Researchers discover hormone that controls supply of iron in red blood cell production
9. Some high blood pressure drugs may be associated with increased risk of vision-threatening disease
10. Virtual human shows that stiff arteries can explain the cause of high blood pressure
11. Game changer: Patients of doctors who played online game had better control of blood pressure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , the ... Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , “We ... new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... NAMUR , Belgium , ...  (NYSE MKT: VNRX), today announced the appointment of ... Board of Directors as a Non-Executive Director, effective ... the Company,s Audit, Compensation and Nominations and Governance ... Board, Dr. Futcher will provide independent expertise and ...
(Date:6/23/2016)... -- Research and Markets has announced the ... (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, ... Global Forecast to 2021" report to their offering. ... pharmaceutical excipients market is projected to reach USD 8.1 ... the forecast period 2016 to 2021. ...
(Date:6/23/2016)... Research and Markets has announced the addition of the ... offering. The current unmet ... for MedImmune to enter. The US ageing population creates a ... considerable growth for effective anti-influenza medications. The introduction of a ... development is still in its infancy. Key ...
Breaking Medicine Technology: