Navigation Links
Blood product sterilization taken too far?
Date:6/12/2014

Certain processes used to sterilize blood products could potentially cause serious health issues in transfusion recipients, according to an international study published in the journal Platelets and led by Dr. Patrick Provost of Universit Laval's Faculty of Medicine and the CHU de Qubec Research Center. These processes purportedly alter the blood platelets to the extent of preventing them from carrying out their functions correctly and may be the cause of hemorrhages observed in patients having received treated blood.

The function of platelets goes far beyond their role in blood coagulation and wound healing. They contain up to a third of the human genome in the form of ribonucleic acid (RNA), allowing them to synthesize over 1,000 proteins essential to the normal functioning of the human body.

The presence of this genetic material explains why platelets are affected by pathogen reduction treatments. "The processes that are used target the genetic material of pathogenic organisms," explains Patrick Provost. "They were developed more than 20 years ago, before we understood the importance of the genetic material contained in platelets."

Dr. Provost and his colleagues discovered that these treatments activate blood platelets, triggering the release of RNA. "The platelets end up depleted of RNA so, once transfused, they're unable to do what they normally would," says the researcher.

The treatments are already on the market in some European countries, notably Switzerland, France, and Germany. Manufacturers are trying to get approval in other countries, including Canada and the United States. Professor Provost regrets the dearth of independent studies that have focused on the safety of the processes and hopes regulatory authorities such as Health Canada and the U.S. Food and Drug Administration will take these results into consideration. "In light of what we have demonstrated, the potentially harmful effects of these treatments should be carefully evaluated in the countries where they are not yet approved. It should also be re-evaluated in those countries where they are," concludes Provost.


'/>"/>
Contact: Jean-François Huppé
jean-francois.huppe@dc.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Related medicine news :

1. Mount Sinai researchers identify protein that keeps blood stem cells healthy as they age
2. Bloodstream infections reduced through better central line care at three hospitals
3. Mayo Clinic moves small-molecule drugs through blood-brain barrier
4. Experts recommend blood, urine testing to diagnose rare adrenal tumors
5. CPAP rapidly improves blood pressure and arterial tone in adults with sleep apnea
6. Surgeons report fewer postoperative blood clots using risk-based preventive measures
7. Why inflammation leads to a leaky blood-brain barrier: MicroRNA-155
8. Researchers discover hormone that controls supply of iron in red blood cell production
9. Some high blood pressure drugs may be associated with increased risk of vision-threatening disease
10. Virtual human shows that stiff arteries can explain the cause of high blood pressure
11. Game changer: Patients of doctors who played online game had better control of blood pressure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... , ... December 08, 2016 , ... Vida ... an $18M Series B led by Canvas Ventures . Other investors include Nokia ... scale its mobile platform to serve more consumers who are managing chronic conditions ...
(Date:12/8/2016)... ... December 08, 2016 , ... The ... offices headquartered in Jefferson County, is announcing the launch of a charity drive ... The number of homeless women and children in Birmingham has grown steadily since ...
(Date:12/8/2016)... Louis, MS (PRWEB) , ... December 08, 2016 , ... ... that serve commercial and residential clients in and around the Hancock County area, is ... for the Hancock County Food Pantry. , The Hancock County Food Pantry has worked ...
(Date:12/7/2016)... PA (PRWEB) , ... December 07, 2016 , ... ... with the announcement that it is one of the early adopters completing EU-U.S. Privacy ... Framework is designed to provide companies on both sides of the Atlantic with a ...
(Date:12/7/2016)... (PRWEB) , ... December 07, 2016 , ... Kenall Manufacturing, ... new MedMaster™ MPCNGX . The MPCNGX is a multi-function, sealed, LED luminaire that ... amount of light where and when it’s needed. , A 2’ x ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... , Dec 8, 2016 Research and Markets ... report to their offering. ... The global chromatography market to grow ... Global Chromatography Market 2016-2020, has been prepared based on an in-depth market ... and its growth prospects over the coming years. The report also includes ...
(Date:12/8/2016)... 8, 2016 According to ... by Product (Actual Sugars, Sugar Alcohols, Artificial Sweeteners), ... Tonicity Agents), Formulation (Oral, Topical, Parenteral) - Global ... has witnessed healthy growth during the last decade, ... of 4.3% between 2016 and 2021 to reach ...
(Date:12/8/2016)... 8, 2016  Agenovir Corporation, a company using ... therapeutics, today announced that it appointed Dirk ... a member of the board of directors. ... a deep background in both founding and building ... Agenovir, co-president of Chan Zuckerberg  Biohub and ...
Breaking Medicine Technology: