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Blood-pressure-lowering drug after stroke aids recovery, study finds
Date:10/21/2011

oon after a stroke could lessen amounts of critical oxygen to the brain. Fagan cited a large clinical trial conducted earlier this year by Scandinavian researchers who concluded that using candesartan to lower blood pressure early after stroke produced no real benefit. In order to bypass the blood pressure debate, Fagan's lab plans to pursue future research with drugs and doses that provide protection to the brain's blood vessels without lowering blood pressure.

The study also found that animals treated with candesartan had increased levels of a "pro-survival" protein in both brain hemispheres. The protein is responsible for helping neurons in the brain survive insultslike a strokeand promote longer life. Fagan said the study contributes to a body of literature that finds new potential for drug therapy.

"We tell patients the reason they go to rehab after they've had a stroke is to retrain and make new connections so that they can get function back. Maybe it's because the other hemisphere takes over," Fagan said. "If we could stimulate that with drug therapy and make it even more so, it would help lots of people."


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Contact: Susan C. Fagan
sfagan@georgiahealth.edu
706-721-0130
University of Georgia
Source:Eurekalert

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