Navigation Links
Blood pressure enzyme can have tumor-sensing role
Date:4/7/2008

ds, the building blocks of proteins, from one end of a larger protein. In the body, ACE converts an inactive form of angiotensin into an active form by clipping off two amino acids.

But angiotensin is not ACE's only target. In previous studies, Bernstein and his co-workers found that manipulating its activity also affects processes such as fertility and the generation of red blood cells in the bone marrow.

To dissect out ACE's role in the immune system, they created mice with a genetic alteration in the ACE gene, forcing the gene to be turned on only in macrophages.

Macrophages are especially good at displaying peptides on their surfaces to other white blood cells called T cells so that the T cells are stimulated to grow. The T cells in turn kill virally infected cells. Depending on the situation, they can sometimes kill tumor cells as well.

When injected with several types of melanoma or lymphoma, the altered mice developed smaller tumors than normal mice. The tumors they did have contained more white blood cells attacking the cancerous cells.

In the JBC paper, the researchers show that ACE boosts cells' ability to display some foreign peptides, increasing their ability to stimulate T cells by several-fold.

Bernstein cautions that normally, macrophages make little ACE, so its effects must be seen as artificial. He notes that ACE inhibitors such as enalapril and lisinopril are taken by millions of people with high blood pressure and have not been reported to weaken the immune system.

However, cells similar to macrophages have been shown to produce ACE in response to pathogens such as sarcoid or leprosy, he says.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Specific antagonism lowers blood pressure
2. Restricting Blood Flow May Help Heart Bypass Patients
3. FDA Updates Prescription Guidelines for Blood Thinner
4. Doctors Often Miss High Blood Pressure in Kids
5. Back to School Means Return of School Blood Drives
6. Blood-flow detector software show promise in preventing brain damage
7. FDA Approves New Roche West Nile Virus Blood Screening Test
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Laser blasts viruses in blood
10. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
11. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/14/2014)... News) -- Getting enough sleep each night may mean you,re less ... new study suggests. The study included more than 3,700 people ... average of seven years. Those who slept less than six ... likely to have extended absences from work due to illness, the ... from work due to sickness were those who slept between seven ...
(Date:9/14/2014)... 2014 Top10BestSEOHosting.com always offers truly ... web host suppliers carefully, the site has announced ... are the Best WordPress Hosting suppliers in the ... a top web hosting provider, and the company’s ... web hosting provider known for its flexible hosting ...
(Date:9/14/2014)... A new DePuy Pinnacle hip lawsuit has ... behalf of a Franklin County, Ohio man who underwent hip ... metal-on-metal hip lawsuit filed against Johnson & Johnson and its ... 40 years old when the Pinnacle Hip device was surgically ... According to the hip implant lawsuit , the man underwent ...
(Date:9/14/2014)... School requires that children read at both near ... screened only for far vision when they enter school. , ... their eyes do not track effectively or focus (team) on ... avoid reading; at worst, they will think there is ... Children who cannot see cannot read. , On November ...
(Date:9/13/2014)... Recently, an experienced supplier of wedding ... its new collection of eggplant evening dresses . ... discounted rates, up to 58% off. According to the ... September 23. , The company’s new items are ... vintage, plus size, modest, sexy outfits and so on. ...
Breaking Medicine News(10 mins):Health News:A Good Night's Sleep May Mean a Good Day's Work 2Health News:Top10BestSEOHosting.com: The Best Linux Web Hosting Suppliers Now Unveiled 2Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 2Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 3Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 4Health News:Wright & Schulte LLC Files Another DePuy Pinnacle Hip Lawsuit Purporteding Risky Revision Surgery Needed Due To Failure of Metal-on-Metal Hip Replacement 5Health News:Cheap Eggplant Evening Dresses Now Announced By Experienced Company iFitDress.com 2
... , , ST. PAUL, Minn., ... WorkFit(TM) workstation, a new sit-or-stand mobile computer workstation that enables ... to a seated position whenever they wish - reducing back ... more productive computing. , , The ...
... , , , ... is pleased to announce that is has added a new module ... interactions with patients. "Customer service and employee motivation are two ... their employees," says Dr. Kenneth Beer. , , ...
... , , MEMPHIS, Tenn., ... are seeing donations decline, St. Jude Children,s Research Hospital((R)) is receiving ... of the sixth annual Create-A-Pepper to Fight Childhood Cancer ... will observe National Childhood Cancer Awareness Month by inviting guests to ...
... , , , , ... Health , a comprehensive health care provider in ... Wilson A sfora, MD , ... United States Food and Drug Administration (FDA) 510(k) market clearance as a lumbar ...
... SHANGHAI, Aug. 27 /PRNewswire-Asia/ -- Linkwell Corporation (OTC ... disinfectants in China, announced that its 90% held,subsidiary, Shanghai ... Shield of Likang -- The Establishment of One Hundred ... 2009 to September,2010. , The ...
... 27, 2009) In a victory for families who dug ... Institutes of Health has awarded a $3.5-million grant to the ... for human clinical trials in a bid to halt ... human trials within four years, the NIH award was eagerly ...
Cached Medicine News:Health News:New WorkFit Ergonomic Workstations From Ergotron 'Take a Stand' for 21st Century Office Computing 2Health News:New WorkFit Ergonomic Workstations From Ergotron 'Take a Stand' for 21st Century Office Computing 3Health News:St. Jude Children's Research Hospital(R), Chili's(R) Grill & Bar Kick-off Sixth Annual Create-A-Pepper to Fight Childhood Cancer Campaign 2Health News:St. Jude Children's Research Hospital(R), Chili's(R) Grill & Bar Kick-off Sixth Annual Create-A-Pepper to Fight Childhood Cancer Campaign 3Health News:Spinal Implant Developed by Sanford Clinic Neurosurgeon Receives FDA 510(k) Market Clearance as a Lumbar Intervertebral Body Fusion Device 2Health News:Spinal Implant Developed by Sanford Clinic Neurosurgeon Receives FDA 510(k) Market Clearance as a Lumbar Intervertebral Body Fusion Device 3Health News:Linkwell Corporation Announces Launch of the 'Establishment of 100 Model Hospitals' Across China 2Health News:Linkwell Corporation Announces Launch of the 'Establishment of 100 Model Hospitals' Across China 3Health News:NIH grant advances Tay-Sachs disease gene therapy 2Health News:NIH grant advances Tay-Sachs disease gene therapy 3
(Date:9/12/2014)... N.C. , Sept. 12, 2014 ... device companies increasingly depend upon Health Outcomes Liaison ... with payer organizations, thought leaders, and other important ... and comparative effectiveness data grows, successful companies will ... relatively new field-based HOL function. To ...
(Date:9/12/2014)... 12, 2014 Research ... addition of the  "Patient Handling Equipment Market ... & by End User - Global Forecast ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,The ... lucrative growth potential for the next five ...
(Date:9/12/2014)... -- The report "Food & Beverage ... & Energy Drinks, Others), Food (Fruit & Vegetable, ... Material (Aluminum & Steel) - Global Forecast to ... Food & Beverage Metal Cans Market with analysis ... volumes and values. The application market is sub-segmented ...
Breaking Medicine Technology:Pharmaceutical Sector Turning to Health Outcomes Liaisons to Help Industry Navigate Payer-Focused Marketplace 2Global Patient Handling Equipment (Wheelchair, Scooter, Beds, Bathroom Safety, Mechanical, Ambulatory) Market - Forecast to 2019 2Global Patient Handling Equipment (Wheelchair, Scooter, Beds, Bathroom Safety, Mechanical, Ambulatory) Market - Forecast to 2019 3Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 2Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 3Food & Beverage Metal Cans Market Worth $49.20 Billion by 2019 4
... XIANYANG, China, Oct. 7 /PRNewswire-Asia-FirstCall/ -- Biostar,Pharmaceuticals, ... Company"),a Xianyang-based developer, manufacturer and supplier of pharmaceutical,products ... and,conditions, today announced that the Chinese Military Drug ... the Company,s new drug,application, the Zushima Analgesic Aerosol ...
... Oct. 7 Cleveland Clinic,s Top 10 Medical ... techniques and therapies that are being developed to treat everything ... , The list of breakthrough devices and therapies was ... and it was unveiled during Cleveland Clinic,s 2009 ...
Cached Medicine Technology:Biostar Pharmaceuticals, Inc. Receives the Chinese Military Drug Administration Clearance to Begin Clinical Trial for Zushima Analgesic Aerosol Spray 2Biostar Pharmaceuticals, Inc. Receives the Chinese Military Drug Administration Clearance to Begin Clinical Trial for Zushima Analgesic Aerosol Spray 3Cleveland Clinic Unveils 'Top 10' Medical Innovations for 2010 2Cleveland Clinic Unveils 'Top 10' Medical Innovations for 2010 3Cleveland Clinic Unveils 'Top 10' Medical Innovations for 2010 4
... continues to raise the standard for rapid, ... x g performance and our new 4x5mL ... sizes from 0.2 ml to 8.3 ml, ... drive, very quiet operation, rotor imbalance detection, ...
... has the highest g-force ever. But optimal ... force. Optima MAX combines maximum force, capacity, ... performance that's worlds apart from any other ... and enhanced efficiency, Optima takes productivity to ...
... environmental safety are the hallmarks ... Ultracentrifuge from Beckman Coulter. With ... technology, the LE-80 K is ... advanced capability for your laboratory ...
... of generating 694,000 x g ... rpm, Beckman Coulter's Optima L-90K ... more separations in less time. ... with a broad range of ...
Medicine Products: