Navigation Links
Blood pressure enzyme can have tumor-sensing role
Date:4/7/2008

ds, the building blocks of proteins, from one end of a larger protein. In the body, ACE converts an inactive form of angiotensin into an active form by clipping off two amino acids.

But angiotensin is not ACE's only target. In previous studies, Bernstein and his co-workers found that manipulating its activity also affects processes such as fertility and the generation of red blood cells in the bone marrow.

To dissect out ACE's role in the immune system, they created mice with a genetic alteration in the ACE gene, forcing the gene to be turned on only in macrophages.

Macrophages are especially good at displaying peptides on their surfaces to other white blood cells called T cells so that the T cells are stimulated to grow. The T cells in turn kill virally infected cells. Depending on the situation, they can sometimes kill tumor cells as well.

When injected with several types of melanoma or lymphoma, the altered mice developed smaller tumors than normal mice. The tumors they did have contained more white blood cells attacking the cancerous cells.

In the JBC paper, the researchers show that ACE boosts cells' ability to display some foreign peptides, increasing their ability to stimulate T cells by several-fold.

Bernstein cautions that normally, macrophages make little ACE, so its effects must be seen as artificial. He notes that ACE inhibitors such as enalapril and lisinopril are taken by millions of people with high blood pressure and have not been reported to weaken the immune system.

However, cells similar to macrophages have been shown to produce ACE in response to pathogens such as sarcoid or leprosy, he says.


'/>"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Specific antagonism lowers blood pressure
2. Restricting Blood Flow May Help Heart Bypass Patients
3. FDA Updates Prescription Guidelines for Blood Thinner
4. Doctors Often Miss High Blood Pressure in Kids
5. Back to School Means Return of School Blood Drives
6. Blood-flow detector software show promise in preventing brain damage
7. FDA Approves New Roche West Nile Virus Blood Screening Test
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Laser blasts viruses in blood
10. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
11. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Atlanta-based Jvion, a leader in clinical predictive algorithms ... predictive population health analytics as part of an ongoing ... healthcare. Ritesh Sharma, Jvion COO, commented, “it is critical ... the impact of and potential within predictive analytics. There ... good portion of it is conflicting or confusing. The ...
(Date:7/31/2014)... July 31, 2014 The rising population ... factor driving the global geriatric care services market wherein ... supply of these services across the globe. There are ... home care agency to few large companies with national ... is underserved and is also highly fragmented. The developed ...
(Date:7/31/2014)... the winter of 1944, the Nazis blocked food supplies ... famine and devastation. The impact of starvation on expectant ... changes resulting from external rather than genetic influences ... hardship could be inherited. The underlying mechanism, however, remained ... in the journal Cell , Dr. Oded Rechavi, ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 The ... (Column based, Reagent based, Magnetic bead based), Consumables ... isolation, Total RNA isolation), End users - Global ... the major drivers, restraints, challenges, opportunities, current market ... isolation and purification market along with the estimates ...
(Date:7/31/2014)... Global Markets , Brain Cancer - ... the Brain Cancers therapeutic pipeline. , This report ... Brain Cancer, complete with comparative analysis at various ... action (MoA), route of administration (RoA) and molecule ... and press releases. It also reviews key players ...
Breaking Medicine News(10 mins):Health News:Jvion Releases Top Three Lessons in Predictive Population Health Analytics 2Health News:Jvion Releases Top Three Lessons in Predictive Population Health Analytics 3Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 2Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 3Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 4Health News:Geriatric Care Services Market (Home Care, Adult Day Care, and Institutional Care): Global Industry Analysis, Size, Share, Growth, Forecast 2013 - 2019 5Health News:The 'memory' of starvation is in your genes 2Health News:The 'memory' of starvation is in your genes 3Health News:Nucleic Acid Isolation Market Worth $3,106.28 Million by 2018 - New Research Report by MarketsandMarkets 2Health News:Nucleic Acid Isolation Market Worth $3,106.28 Million by 2018 - New Research Report by MarketsandMarkets 3Health News:Nucleic Acid Isolation Market Worth $3,106.28 Million by 2018 - New Research Report by MarketsandMarkets 4Health News:Global Brain Cancer Market Size, Share, Analysis, Trends and Forecasts 2014 2Health News:Global Brain Cancer Market Size, Share, Analysis, Trends and Forecasts 2014 3Health News:Global Brain Cancer Market Size, Share, Analysis, Trends and Forecasts 2014 4
... relationship between language functioning and schizophrenia, and verbal ... significantly negative consequences for real world social functioning. ... some forms of memory are selectively impaired in ... contextual verbal memory impairment that may be associated ...
... knows - Women feel more pain than men.// ,The ... them to feel pain more intensely than men. According to researcher ... women averaged 34 nerve fibres per square centimetre of facial skin ... of the US population suffers from acute pain and 25 ...
... of Pittsburgh have successfully treated heart failure in an animal ... dystrophy. The article detailing this study is published in the ... that this is the first time that a gene therapy ... author, Xiao Xiao, Ph.D., associate professor of orthopedic surgery at ...
... type of histories all the time. Now for the first ... boy after one of them was left infertile after she ... from Woolwich in southeast London was declared infertile and her ... their eldest sister carried the fetus in her womb to ...
... is produced from the leaves of the evergreen plant ... tea are polyphenolic compounds, known as catechins. Catechins of ... // ht, including (-)-epigallocatechin gallate (EGCG), (-)-epigallocatechin (EGC), ... for approximately 50% of the total amounts of catechins ...
... pluripotent hematopoietic stem cell disorder characterized by accumulation of ... marrow due to uncontrolled growth // and resistance ... tyrosine kinase, which is encoded by the bcr?abl fusion ... malignant phenotypes. , ,Gleevec, which is an inhibitor ...
Cached Medicine News:Health News:Prose Memory Deficits Found To Be Associated With Schizophrenia 2Health News:Gene Therapy Overcomes Heart Failure In Muscular Dystrophy 2Health News:Catechins in green tea show antiviral effect on influenza virus 2Health News:The potent anti-leukemia activity of Berbamine 2
(Date:7/31/2014)... TB Alliance, a not-for-profit with the ... affordable treatments, announced the appointment of Willo ... Mr. Brock comes to TB Alliance having most ... for WWF International (formerly known as the World ... guide the TB Alliance,s resource development, advocacy and ...
(Date:7/31/2014)... NEW YORK und KISSING, Deutschland, ... ein Hersteller und Distributor eines computerunterstützten („robotischen") ... Nachum (Homi) Shamir , ein weltweit ... seines Leitungs- und Kontrollgremiums zum Unternehmen stößt. ... Shamir ist ein hochangesehener ...
(Date:7/31/2014)... Nutrastar International Inc. (OTCQB: NUIN; "Nutrastar" or ... branded consumer products, including commercially cultivated Cordyceps Militaris ("Cordyceps"), ... the signing of its first distributor for its new ... Hubei Province located in ... . The contract with the new ...
Breaking Medicine Technology:TB Alliance Appoints Willo Brock Senior Vice President, External Affairs 2invendo medical holt Nachum (Homi) Shamir in den Board of Directors des Unternehmens 2invendo medical holt Nachum (Homi) Shamir in den Board of Directors des Unternehmens 3Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 2Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 3Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 4
... 14, 2012  Nephros, Inc. (OTC Bulletin Board: ... filtration products for therapeutic applications, infection control, and water ... Sullivan as Director of U.S. Sales. Mr. ... leadership role in the healthcare, life science and biopharmaceutical ...
... HealthCare Pharmaceuticals Inc. today announced that the U.S. Food ... for Natazia® (estradiol valerate and estradiol valerate/dienogest) tablets for ... not caused by any diagnosed conditions of the uterus ... for contraception.  With this approval, Natazia is the first ...
Cached Medicine Technology:Nephros Hires Director of U.S. Sales 2Nephros Hires Director of U.S. Sales 3Nephros Hires Director of U.S. Sales 4Nephros Hires Director of U.S. Sales 5Nephros Hires Director of U.S. Sales 6U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 2U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 3U.S. FDA Approves First and Only Oral Contraceptive Demonstrated to Treat Heavy Menstrual Bleeding (HMB) 4
... injection of contrast medium, anesthetic gel, and/or ... eliminates the need for multiple catheterizations. The ... passage into and through the ureter. AQ ... that when activated, attracts and holds water ...
Used for drainage and retrograde pyelogram. Supplied sterile in peel-open packages. Intended for one-time use....
... The whistle tip has two ... plastic and the Luer fitting adapter ... for identification of left or right. ... sterile and x-ray opaque. The length ...
Used for directing a flexible tipped wire guide in the ureter. The angled tip allows passage of the catheter past a ureteral stone in preparation for E.S.W.L. Supplied sterile in peel-open packages. ...
Medicine Products: