Navigation Links
Blood pressure drugs may lengthen lives of melanoma patients
Date:9/20/2011

COLUMBUS, Ohio Beta-blocker drugs, commonly used to treat high blood pressure, may also play a major role in slowing the progression of certain serious cancers, based on a new study.

A review of thousands of medical records in the Danish Cancer Registry showed that patients with the skin cancer melanoma, and who also were taking a specific beta-blocker, had much lower mortality rates than did patients not taking the drug.

The report, published in the current issue of the journal Cancer Epidemiology, Biomarkers & Prevention, summarized the work of a team of researchers at Ohio State University's Institute for Behavioral Medicine Research (IBMR) and the Comprehensive Cancer Center.

If the results are confirmed in a planned clinical trial, this might be an additional adjunct treatment for cancer patients facing a poor prognosis.

At the center of this research is the fact that certain molecules that play important roles in the immune system also appear to promote both tumor growth and metastasis, the shedding and spreading of tumor tissue to other parts of the body.

"The work started with some earlier studies where we discovered that certain tumor cells had receptors to two specific catecholamine stress hormones epinephrine and norepinephrine," explained Ron Glaser, professor of molecular virology, immunology and medical genetics and director of the IBMR.

"When either of these hormones bind to the tumor cell receptors, it stimulates the production of vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), interleukin-6 (IL-6) and certain matrix metalloproteins all molecules known to stimulate blood flow to tumors, enhancing their growth, and promoting metastasis."

The earlier studies first used tissue from a nasopharyngeal carcinoma cell line, and later from both multiple myeloma and melanoma cell lines. When treated with the beta-blocker propranol, all cells stopped producing the tumor-enhancing molecules. Similar work by other scientists showed similar results with ovarian cancer tissues.

Then the team turned to Stanley Lemeshow, a professor and dean of the College of Public Health at Ohio State. Lemeshow had previously partnered with colleagues in Denmark and knew that country had a vast database of patient information, including records of all Danish cancer patients for decades, as well as pharmacy records of all drugs prescribed for those patients.

"These databases can be linked together and by doing so, you have the ability to find patients with melanoma who had previously been prescribed beta-blockers," Lemeshow said.

The researchers looked at melanoma patients who had taken beta-blockers and at those who hadn't to determine whether the former group exhibited longer survival.

"Among patients diagnosed with melanoma, those who were taking beta-blockers when their cancer was diagnosed experienced longer survival than those patients who weren't taking the drug," Lemeshow said.

"Their chance of surviving for a specified number of years improved by 13 percent."

When the researcher looked at all causes of death among melanoma patients not just melanoma their chances of survival were improved by 19 percent.

"We're talking about survival time, here. They simply lived longer."

Eric Yang, an associate member of the IBMR and assistant research professor of internal medicine, said that epinephrine and norepinephrine may stimulate, or induce, the production of these tumor-promoting molecules.

"The idea is that if you treat a patient with beta-blockers, then you can counteract 'epi' and 'norepi' and lower the amounts of those molecules that induce tumor progression, perhaps halting it," Yang said.

That's the idea behind the clinical trial the researchers hope to begin soon.

"That's what has us so excited," Glaser explained. "This drug is relatively inexpensive. It isn't chemotherapy so you don't lose your hair or get sick. It doesn't kill the cancer cells, but it may slow the disease.

"This would be adjunct therapy that could be provided in addition to the normal chemotherapy patients receive."

"So far, we've found an association between beta-blocker use and survival time for melanoma patients," Lemeshow said. "The clinical trial should give us even stronger evidence."


'/>"/>

Contact: Ronald Glaser
glaser.1@osu.edu
614-292-5526
Ohio State University
Source:Eurekalert

Related medicine news :

1. Inflammatory Bowel Ups Risk for Blood Clots
2. Bowel disease link to blood clots
3. Local Blood Supply Impacted by Wednesdays Severe Snow Storm
4. PERSONALABS Offers Discounted Healthy Heart Online Blood Tests in February
5. China Cord Blood Corporation Warrant Registration Statement Declared Effective by SEC
6. NIH grants to Childrens Hospital will advance novel stem cell treatments for blood disorders
7. Bilberry Seems to Act Against Blood Sugar
8. Johns Hopkins scientists develop personalized blood tests for cancer using whole genome sequencing
9. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
10. NHLBI, CDC launch surveillance and research program for inherited blood diseases
11. IOM report declares high blood pressure a neglected disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... York, New York (PRWEB) , ... January 24, 2017 , ... ... for Brazilian butt lifts is on the rise. According to the American Society ... augmentations since 2000. On average, these procedures are performed every 30 minutes of every ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... solution provider of enterprise software products, today announced a strategic partnership with ... Blue users to access and analyze their Fusion platform for building powerful enterprise ...
(Date:1/24/2017)... Calverton, MD (PRWEB) , ... January 24, 2017 , ... ... Year by MSC Cruises as part of the line’s 4th Annual MSC True ... Cruises’ top performing North American travel partners for the year based on overall business ...
(Date:1/24/2017)... ... January 24, 2017 , ... West’s Health Advocate Solutions, ... Series of webinars will start January 31 with a session about understanding healthcare ... health and benefits topics, including employee engagement, pricing transparency, population health and wellness, ...
(Date:1/24/2017)... ... January 24, 2017 , ... Center for Hispanic ... leadership, has named Hector M. Chavez, Manager, Employee & Labor Relations at City ... as its Hispanic Leader of the Month. City of Hope is committed to stay ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... 2017  BioSpecifics Technologies Corp. (NASDAQ: ... originated and continues to develop collagenase based-therapies ... collagenase clostridium histolyticum, or CCH, marketed as ... ®  in Europe, today announced that BioSpecifics, President, Tom ... the upcoming NobleCon13 - Noble Capital Markets, ...
(Date:1/24/2017)... MOINES, Iowa , Jan. 24, 2017 When tragedy ... who the victim is, what conditions they have, and who back ... was created—to keep loved ones informed about the safety of their ... information they need about victims in times of crisis. ... If you find yourself or ...
(Date:1/24/2017)... PORTLAND, Oregon and PUNE, India ... A new report published by Allied Market Research, titled, ... Vegetables, Bakery & Confectionary, Dairy & Frozen Dessert, Meat, ... Industries): Global Opportunity Analysis and Industry Forecasts, 2014-2022," projects ... to garner $426,275 million by 2022, growing at a ...
Breaking Medicine Technology: