Navigation Links
Blood pressure drug curbs brain damage from PTSD
Date:11/6/2007

PORTLAND, Ore. - A drug used to treat high blood pressure and enlargement of the prostate may protect the brain from damage caused by post-traumatic stress disorder, Alzheimer's disease, depression and schizophrenia.

Prazosin, also prescribed as an antipsychotic medication, appears to block the increase of steroid hormones known as glucocorticoids, Oregon Health & Science University and Portland Veterans Affairs Medical Center researchers have found. Elevated levels of glucocorticoids are associated with atrophy in nerve branches where impulses are transmitted, and even nerve cell death, in the hippocampus.

The hippocampus is the elongated ridge located in the cerebral cortex of the brain where emotions and memory are processed.

"It's known, from human studies, that corticosteroids are not good for you cognitively," said study co-author S. Paul Berger, M.D., assistant professor of psychiatry and behavioral neuroscience, OHSU School of Medicine and the PVAMC. "We think prazosin protects the brain from being damaged by excessive levels of corticosteroid stress hormones."

The study, titled "Prazosin attenuates dexamethasone-induced HSP70 expression in the cortex," is being presented during a poster session today at Neuroscience 2007, the annual Society for Neuroscience conference in San Diego.

Scientists believe stress activates a neurochemical response in the brain that triggers the release of glucocorticoids in the brain, and that high levels of glucocorticoids in blood serum are associated with such psychiatric conditions as schizophrenia, depression, PTSD and Alzheimer's disease. This mechanism has been linked to decreases in cognitive performance in older people who are not suffering from clinical dementia.

"Our hypothesis is that just being afraid of being blown up all the time means you have high levels of steroids all the time," Berger said, referring to PTSD among military personnel.

Low level
'/>"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Specific antagonism lowers blood pressure
2. Restricting Blood Flow May Help Heart Bypass Patients
3. FDA Updates Prescription Guidelines for Blood Thinner
4. Doctors Often Miss High Blood Pressure in Kids
5. Back to School Means Return of School Blood Drives
6. Blood-flow detector software show promise in preventing brain damage
7. FDA Approves New Roche West Nile Virus Blood Screening Test
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Laser blasts viruses in blood
10. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
11. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... If Dr. Lawrence Power has his way, the innovative ... http://www.HealthYourself101.com will expand people’s understanding of the causes, consequences, ... out to provide a health education platform on this modern ... say it? – entertaining to dig into and learn from. ... remote learner – the solitary individual signing on from a ...
(Date:7/12/2014)... Recently, Fadhits.com, a well-known wedding dress manufacturer ... graduation dresses to its product line. In addition, ... clients. It wants to bring more benefits for its loyal ... at discounted prices, up to 72% off. , As a ... hard. Its online shop is a good place for ladies ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 The rise ... has urged for new advanced network architectures to suit ... the IT industry with increasing cloud storage technologies. The ... advent of more mobility devices. This has resulted in ... the main driving forces for the SDN market. , ...
(Date:7/12/2014)... 12, 2014 Demand Response Management Systems ... benefits in reducing the imbalance between energy supply and ... have been rolled out (due to increasing pressure on ... This helps in controlling residential appliances and thermostats for ... the North American region, and with government mandates and ...
(Date:7/12/2014)... If you make exercise fun, you,ll eat less after your ... were led on a 1.4-mile walk and were either told ... The participants were given lunch after the walk, and those ... percent more chocolate pudding for dessert than those who were ... 46 adults were given mid-afternoon snacks after their walk. Those ...
Breaking Medicine News(10 mins):Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 3Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 4Health News:New Collection of Long Graduation Dresses Revealed by Fadhits.com 2Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 4Health News:North America Software Defined Network (SDN) Market Worth $1,443.8 Million by 2019 - New Report by MicroMarket Monitor 5Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Demand Response Management System Worth $12,522.4 Million by 2019 - New Report by MicroMarket Monitor 4Health News:Make Exercise Fun, Eat Less Afterwards 2
... 19 People who have experienced the,death of a ... family traditions will never be the same; the hope ... depression and loneliness. This,year,s economic downturn will add even ... financial circumstances. , ...
... issues around patient comfort gaining,momentum, hospitals and healthcare decision ... welfare. This is leading to a growing demand for,patient ... greater,number of patients and not just the aged and ... http://www.newscom.com/cgi-bin/prnh/20081117/FSLOGO ) , ...
... Sex, Less Pain, researchers examine a non-surgical therapy to treat ... ... (PRWEB) November 19, 2008 -- Endometriosis is a painful and debilitating ... quality of life. While the cause of endometriosis is unknown, some ...
... Firm Makes Informational Center Available to People Affected by Plastics Plant Fire ... ... law firm Williams Kherkher has set up an informational resource center ... plant in Deer Park. , ,At approximately 7:15 AM Tuesday morning, ...
... highlights need for complete, unbiased information on Medicare choices. ... ... 2008 - Medicare beneficiaries trying to sort through their healthcare ... them against overly aggressive marketing tactics by some insurance companies ...
... patients, the resulting acne scars which last long ... psychosocial distress. Now, a new study recently ... 2008 issue), the peer-reviewed professional journal of the ... that a novel laser device combining CO2 ablation ...
Cached Medicine News:Health News:Surviving the Holidays After a Loved One's Death: Economic Woes Add to Holiday Pressure for People Who Grieve 2Health News:Patient Temperature Management Systems Enjoying Wider Usage 2Health News:Patient Temperature Management Systems Enjoying Wider Usage 3Health News:Alternative Therapy for Adhesion and Endometriosis Pain Examined in New Book 'Miracle Moms, Better Sex, Less Pain' 2Health News:Alternative Therapy for Adhesion and Endometriosis Pain Examined in New Book 'Miracle Moms, Better Sex, Less Pain' 3Health News:Williams Kherkher Provides Resource Center after Deer Park Plant Fire 2Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 2Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 3Health News:New Medicare Advantage Marketing Rules Help People Make Informed Choices, Allsup Says, , 4Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 2Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 3Health News:New Study Finds CO2 Ablative Fractional Resurfacing Safe And Effective For Deep Acne Scarring 4
(Date:7/10/2014)...  The U.S. Department of Health and Human Services ... (UH) Case Medical Center Seidman Cancer Center totaling $4.7 ... improving care for patients with complex cancer. ... a unique model developed at UH to enhance care ... or demonstrated need for high health care utilization.  ...
(Date:7/10/2014)... July 10, 2014 Yesterday, former Congressman ... medical device manufacturing facility. Rep. Kennedy and ... monitors facilitate cutting-edge research in neurological disease and ... mental health advocate, Garen Staglin , created ... fostering fundamental changes that will radically accelerate the ...
(Date:7/10/2014)... 10, 2014  Decision Resources Group finds that ... (ID) specialists are willing to prescribe Durata,s Dalvance ... use as OPAT, approximately two-thirds of the respondents ... their hospital inpatients. However, our findings indicate that ... initiated on OPAT following hospital discharge, and most ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... Ill., Sept. 29 Earlier this year, the National Association ... introduced to the AWARxE campaign, which was created and implemented ... power of the campaign, NABP obtained the AWARxE program so ... The Foundation was inspired to create the ...
... Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution -- ABBOTT PARK, Ill., Sept. 29 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
Cached Medicine Technology:NABP Purchases AWARxE Consumer Protection Program 2Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 2Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 3Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 4Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 5Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 6Abbott Receives FDA Market Clearance for Next-Generation Contact Lens Disinfecting Solution 7
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: