Navigation Links
Blood pressure drug curbs brain damage from PTSD
Date:11/6/2007

PORTLAND, Ore. - A drug used to treat high blood pressure and enlargement of the prostate may protect the brain from damage caused by post-traumatic stress disorder, Alzheimer's disease, depression and schizophrenia.

Prazosin, also prescribed as an antipsychotic medication, appears to block the increase of steroid hormones known as glucocorticoids, Oregon Health & Science University and Portland Veterans Affairs Medical Center researchers have found. Elevated levels of glucocorticoids are associated with atrophy in nerve branches where impulses are transmitted, and even nerve cell death, in the hippocampus.

The hippocampus is the elongated ridge located in the cerebral cortex of the brain where emotions and memory are processed.

"It's known, from human studies, that corticosteroids are not good for you cognitively," said study co-author S. Paul Berger, M.D., assistant professor of psychiatry and behavioral neuroscience, OHSU School of Medicine and the PVAMC. "We think prazosin protects the brain from being damaged by excessive levels of corticosteroid stress hormones."

The study, titled "Prazosin attenuates dexamethasone-induced HSP70 expression in the cortex," is being presented during a poster session today at Neuroscience 2007, the annual Society for Neuroscience conference in San Diego.

Scientists believe stress activates a neurochemical response in the brain that triggers the release of glucocorticoids in the brain, and that high levels of glucocorticoids in blood serum are associated with such psychiatric conditions as schizophrenia, depression, PTSD and Alzheimer's disease. This mechanism has been linked to decreases in cognitive performance in older people who are not suffering from clinical dementia.

"Our hypothesis is that just being afraid of being blown up all the time means you have high levels of steroids all the time," Berger said, referring to PTSD among military personnel.

Low level
'/>"/>

Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Specific antagonism lowers blood pressure
2. Restricting Blood Flow May Help Heart Bypass Patients
3. FDA Updates Prescription Guidelines for Blood Thinner
4. Doctors Often Miss High Blood Pressure in Kids
5. Back to School Means Return of School Blood Drives
6. Blood-flow detector software show promise in preventing brain damage
7. FDA Approves New Roche West Nile Virus Blood Screening Test
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Laser blasts viruses in blood
10. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
11. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... Since September 2014, the country singer has ... after having been in retirement for a period of 13 ... to return to touring, and concert events have been booking ... likely sell out for the two shows recently scheduled for ... view the inventory of discounted Garth Brooks tickets for sale. ...
(Date:3/27/2015)... March 27, 2015 Airy Jeanine is ... the official music video for her debut song “Mama’s ... Combining live-action and abstract styling effects, the thematic video ... on YouTube, Vimeo, and assorted outlets. It will be ... of an expanding full-scale marketing strategy. The video promotion ...
(Date:3/27/2015)... 27, 2015 Canadian Cannabis Clinics ... prescribing and utilization of medical cannabis as a ... of doctors and clinics dedicated to providing access ... trusted gateway for patients searching for medical marijuana ... recently launched their sub domain for Canada. ...
(Date:3/27/2015)... CA (PRWEB) March 27, 2015 Smile ... leading providers of business support services to dental groups ... of an affiliated Castle Dental office in ... Blvd. Hendersonville, TN 37075, this new Castle Dental office ... can receive the latest in comprehensive, quality dental care. ...
(Date:3/27/2015)... April 2015 is the 150th anniversary of the end of ... war and the amazing President that led our country through ... Civil War and Abraham Lincoln. This moving event will be ... Pickens Theater in Newport, RI. , Chief Justice (Ret.) ... master of ceremonies. Dr. Fred Zilian, educator, writer and actor, ...
Breaking Medicine News(10 mins):Health News:Garth Brooks Tickets for Omaha: BuyCheapTicketsToEvents.com Draws Customers by Discounting Prices on 2015 Tickets for Garth Brooks’ Tour Stops at CenturyLink Center 2Health News:Airy Jeanine Releases ‘’Mama’s Girl” Official Music Video 2Health News:Canadian Cannabis Clinics (CCC) to Join the Canada.MarijuanaDoctors.com Network 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 2Health News:Castle Dental® Opens Its First Dental Office in Hendersonville, TN 3Health News:Relive the Civil War, the Presidency and Shocking Assassination of Abraham Lincoln through Lincoln’s Own Words and the Music of a 46-Piece Orchestra 2Health News:Relive the Civil War, the Presidency and Shocking Assassination of Abraham Lincoln through Lincoln’s Own Words and the Music of a 46-Piece Orchestra 3Health News:Relive the Civil War, the Presidency and Shocking Assassination of Abraham Lincoln through Lincoln’s Own Words and the Music of a 46-Piece Orchestra 4
... , ... ... , , , ... ...
... patient records, funded by the Wellcome Trust, suggests that older ... GPs for investigation later than younger women. Researchers ... the General Practice Research Database (GPRD) and compared recorded diagnoses ... to see whether there was a difference in how older ...
... be linked to a slight rise in high blood pressure, ... drinkers can take heart from a series of studies presented ... , For example, coffee drinkers appear to have a lower ... indication that having a few cups every day increases the ...
... ... ... , , ... ...
... , ... ... ... ...
... in front of TV, computer linked to less bonding with ... -- Too much time in front of computers or televisions ... their parents and peers, a new study suggests. , The ... 15, who provided details about how they spent their free ...
Cached Medicine News:Health News:KV Pharmaceutical Subsidiary Pleads Guilty to Two Felonies Regarding Oversized Drugs 2Health News:KV Pharmaceutical Subsidiary Pleads Guilty to Two Felonies Regarding Oversized Drugs 3Health News:KV Pharmaceutical Subsidiary Pleads Guilty to Two Felonies Regarding Oversized Drugs 4Health News:Study finds delay in referrals for older women with ovarian cancer 2Health News:Study finds delay in referrals for older women with ovarian cancer 3Health News:Coffee Is Generally Heart-Friendly 2Health News:Coffee Is Generally Heart-Friendly 3Health News:2010 Caring Coalition Conference Welcomes Author Gail Sheehy 2Health News:2010 Caring Coalition Conference Welcomes Author Gail Sheehy 3Health News:Mylan Files Annual Report on Form 10-K for Year Ended Dec. 31, 2009 2Health News:Screen Time May Take a Toll on Kids' Relationships 2
(Date:3/26/2015)... -- The Burzynski Research Institute, Inc. (BRI) announced today that ... Department of Surgery at Kurume University Medical Center ... published. The study, a randomized non-blinded phase 2 ... adjuvant therapy with and without Antineoplastons A10/AS2-1 Injections ... A total of 65 patients, with histologically ...
(Date:3/26/2015)... 26, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; CSE:PVO), ("Pivotal" ... focus on Omega-3 therapies for cardiovascular disease and overall ... 763,752 common shares of the Corporation (the "Common Shares"). ... period of December 5 th , 2014 to March ... that is due on or before April 1, 2015. ...
(Date:3/26/2015)... Calif. , March 26, 2015 Huntington ... Gabriel Valley to perform transcatheter aortic valve replacement (TAVR), ... procedure is a revolutionary new way to replace an ... of a heart lung machine. The procedure ... team led by Azhil ( Alex) Durairaj , MD, ...
Breaking Medicine Technology:Pivotal Therapeutics announces payment of interest on outstanding convertible notes 2Huntington Memorial Hospital Performs Groundbreaking Minimally Invasive Replacement of Heart Valves 2
... These markers are available with 16 or 24 ... 6.5mm diameter, and an outer 9.5mm diameter. The markers ... in one single step for a 16 or 24 ... outer points on the cornea to achieve a precise ...
... Micro Shafts For Insertion Through A 1.0mm ... ... For A More Comfortable Approach., ,Recessed Jaws ... Supplied For Protection Of Jaws During Sterilization., ...
... New advancements in diamond technology allow ... used at a more economical cost. Proven ... healing, and insures a superior postoperative result. ... available in a variety of widths and ...
The New Easy-To-Use Disposable Diamond Knife Cleaning System Can Remove Even Baked-On Debris In Seconds. It Is Much More Effective Than Steam Or Blocks Of Styrofoam, Much Safer For Employees As Wel...
Medicine Products: