Navigation Links
Blood levels of fat cell hormone may predict severity of migraines
Date:3/18/2013

rug was given. Eleven women received the drug and nine got the placebo.

The researchers measured blood levels of ADP, a protein hormone secreted from fat tissue and known to modulate several of the pain pathways implicated in migraine. The hormone is also implicated in sugar metabolism, insulin regulation, immunity and inflammation, as well as obesity, which is a risk factor for migraines.

Peterlin and her colleagues looked at total adiponectin levels and two subtypes or fragments of total ADP in circulation in the blood: low molecular weight (LMW)-adiponectin and high molecular weight (HMW)-adiponectin. LMW is comprised of small fragments of ADP and it is known to have anti-inflammatory properties, while HMW is made up of larger fragments of ADP and is known to have pro-inflammatory properties. Inflammatory pathways in blood vessels in the head are at work in migraine headache.

The researchers found that in all 20 participants when levels of LMW increased, the severity of pain decreased. When the ratio of HMW to LMW molecules increased, the pain severity increased.

"The blood tests could predict response to treatment," Peterlin says.

At onset of pain -- even before study drug was given the researchers could identify who would be a responder to treatment and who would not, as there was a greater ratio of HMW to LMW in those who would be responders as compared to those who were not.

After study treatment changes in adiponectin were also seen. Interestingly, in those patients who reported less pain after receiving study drug to treat the migraine whether they got the active migraine medication or a placebo researchers were able to see a decrease in total levels of ADP in the blood.

Peterlin says the findings indicate it may be possible to develop a treatment that would reduce levels of ADP or parts of adiponectin such as HMW or LMW adiponectin. She says should ADP prove to be a biomarker for migraine
'/>"/>

Contact: Stephanie Desmon
sdesmon1@jhmi.edu
410-955-8665
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Infection Might Raise Blood Clot Risk for Older Adults: Study
2. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
3. Common Blood Pressure Drug Safe for Heart Failure: Study
4. Certain Birth Control Pills May Carry Higher Blood Clot Risk: FDA
5. High Blood Pressure May Be Especially Lethal for Blacks
6. Changes in gene expression may help explain high blood pressure in pregnancy
7. Researchers Develop Blood Test for Depression
8. Naturopathic care can improve blood sugar, mood in diabetes
9. Diabetes Groups Issue New Guidelines on Blood Sugar
10. Exercise May Help Patients With High Blood Pressure Live Longer
11. Additional blood pressure screening may reduce incidence of CVD events and death by up to 3 percent
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... July 13, 2014 If Dr. Lawrence Power ... has just launched at http://www.HealthYourself101.com will expand people’s ... , Power has set out to provide a health ... that’s actually – dare we say it? – entertaining to ... Power, “aims to engage the remote learner – the solitary ...
(Date:7/12/2014)... 13, 2014 According to the new ... Systems, Airborne Systems, and Naval Systems) - Global Forecasts ... Security and Surveillance Radar market are estimated to be ... a CAGR of 5.97% to reach $8.61 billion by ... with 47 figures spread through 161 pages and in-depth ...
(Date:7/12/2014)... Passenger Information System market is estimated to grow from ... at an expected CAGR of 26.5% for the period ... in North America is well developed and network infrastructure ... the region. The growing ridership figures in public transport ... driving the North American Passenger Information System market at ...
(Date:7/12/2014)... Dennis Thompson HealthDay ... There,s no way to guarantee that a surgical technique used ... incisions won,t increase the risk of spreading cancer to other ... The advisory panel to the Food and Drug Administration ... called laparoscopic power morcellation -- should sign a written consent ...
(Date:7/12/2014)... 12, 2014 The Security Analytics market ... to $3,376.6 million by 2019, at an expected CAGR ... The challenges to counter the increasing number of security ... outdated cyber defense systems in organizations are enormous. Vendors ... remodeling their existing architecture to develop better and more ...
Breaking Medicine News(10 mins):Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 3Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 4Health News:Security and Surveillance Radar Market Estimated to Reach $8.61 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Security and Surveillance Radar Market Estimated to Reach $8.61 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Security and Surveillance Radar Market Estimated to Reach $8.61 Billion by 2020 – New Report by MarketsandMarkets 4Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Passenger Information System (ICT) Market worth $5,486.88 Million by 2019 - New Report by MicroMarket Monitor 4Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 2Health News:FDA Advisers Weigh Risks of Procedure for Removal of Uterine Fibroids 3Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 2Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 3Health News:North America Security Analytics Market Worth $1,215.2 Million by 2019 - New Report by MicroMarket Monitor 4
... lung cancer (NSCLC), the most common form of lung ... a small group of patients can also be helped ... published in BioMed Central,s open access journal BMC ... factor receptor (EGFR) using RNAi, alongside TKI (or antibody ...
... kind, a consortium of investigators from 13 countries led the ... the Catholic University of Leuven, Belgium in Europe, found that ... likelihood of leaving also had patients who were more satisfied ... The study was released today in the current issue of ...
... HealthDay Reporter , TUESDAY, March 20 (HealthDay News) -- ... epinephrine -- adrenaline -- might do more harm than ... of hundreds of thousands of cases. Japanese researchers ... likely to survive one month, compared with those who ...
... such as kidney failure and endocrine tumors are among ... the common pain relievers in your medicine cabinet be ... Tel Aviv University,s Sackler Faculty of Medicine and the ... are underlying causes of hypertension, which is a major ...
... , TUESDAY, March 20 (HealthDay News) -- Insects ... Chagas disease are well-established and feeding on human blood in ... What remains a mystery, however, is why the insects ... a serious condition that can lead to life-threatening digestive and ...
... , TUESDAY, March 20 (HealthDay News) -- The ... of altitude sickness, according to a new study. ... among the symptoms of altitude sickness, which affects more ... elevations each year to ski, hike or camp. ...
Cached Medicine News:Health News:Double whammy: RNAi enhances lung cancer therapy 2Health News:International research finds quality and safety problems in hospitals throughout 13 countries 2Health News:Adrenaline Therapy for Cardiac Arrest Linked to Worse Outcomes 2Health News:Adrenaline Therapy for Cardiac Arrest Linked to Worse Outcomes 3Health News:Pain relievers could be spiking your blood pressure 2Health News:Insects Behind Chagas Disease Are Feeding on Humans in the U.S. 2Health News:Ibuprofen May Ward Off Altitude Sickness 2
(Date:7/10/2014)...  Major advances in radiation therapy and radiosurgery ... in a three-day Oncology Summit taking place in ...  Renowned national and international cancer experts from seven countries ... knowledge on modern technologies making treatment for cancer ... The Summit will address a wide spectrum ...
(Date:7/10/2014)... -- RESMED INC. (NYSE: RMD ) today announced that ... June 30, 2014 results on Thursday, July 31, 2014, after ... with ResMed,s results will be issued after 1:00 p.m. US ... discuss operating results and future outlook. The earnings ... Time and the live webcast of the call can be ...
(Date:7/10/2014)... 2014  Decision Resources Group finds that while ... specialists are willing to prescribe Durata,s Dalvance (dalbavancin) ... as OPAT, approximately two-thirds of the respondents reported ... hospital inpatients. However, our findings indicate that nearly ... on OPAT following hospital discharge, and most are ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
... , , SILVER SPRING, Md. , Feb. ... approved Xiaflex (collagenase clostridium histolyticum) as the first drug to ... can affect a person,s ability to straighten and properly use ... affects the connective tissue found beneath the skin in the ...
... 2 Vermillion, Inc. (Pink Sheets: VRML) today announced the reappointment ... Company and Eric T. Fung , MD, PhD as Senior Vice ... announced appointment of William C. Wallen , PhD to the Board ... Chair of the Board of Directors. , "Both Dr. Fung and I ...
Cached Medicine Technology:FDA Approves Xiaflex for Debilitating Hand Condition 2Vermillion Announces the Reappointment of Officers and Confirmation of Director 2Vermillion Announces the Reappointment of Officers and Confirmation of Director 3Vermillion Announces the Reappointment of Officers and Confirmation of Director 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: