Navigation Links
Blood-incompatible infant heart transplants safe, may save more lives
Date:11/5/2007

ORLANDO, Nov. 5 ABO-incompatible heart transplantation (heart transplantation among non-compatible blood groups) can be safely performed in infants a year old or younger, researchers reported at the American Heart Associations Scientific Sessions 2007.

The analysis, based on national data reported to the United Network for Organ Sharing (UNOS), found that transplanting infant hearts across incompatible blood group is as safe as transplantation with compatible blood group types.

There was no difference in outcome between incompatible and compatible transplantation in these infants, said Luca A. Vricella, M.D., senior author of the study. Survival between the two groups was similar at three years. Nishant Patel, B.A., third-year medical student, presented the study findings at the associations annual conference.

ABO-incompatible heart transplantation can be performed safely in infants with a low incidence of hyperacute rejection, Patel said. ABO-incompatible heart transplantation should be considered in infants to maximize donor organ utilization and reduce mortality among infants.

Vricella said the impact of using incompatible donor hearts could significantly reduce the number of infants who die while on the waiting list to receive donor hearts.

Mortality could be reduced by at least 20 percent by using incompatible donors, said Vricella, chief of pediatric heart transplantation at Johns Hopkins Medical Institutions in Baltimore, Md. There would be a huge impact on infants who otherwise have to rely on a very small donor pool.

Up to 40 percent of infants die while waiting for a donor heart. The average wait on the list exceeds two months.

The whole concept of transplanting infants across blood barriers comes from the necessity to reduce waiting time on the list, Vricella said.

The study examined data on infant heart transplant recipients reported to UNOS from 1999 to 2007. Of the 591 infants who underwent transplantation, 35 infants (6 percent) received hearts from ABO-incompatible donors. Two ABO-compatible infants died from hyperacute rejection, while no ABO- incompatible infants died from hyperacute rejection.

ABO-incompatibility did not predict mortality. The statistical analysis was adjusted for the different size cohorts, assuring statistical significance.

Survival in both groups reached 75 percent at three years after transplantation. Infants with congenital heart disease (defects existing since birth) represent the predominant group requiring transplantation.

In the study, 71 percent of the incompatible recipients had some form of structural heart disease compared to 66 percent in the compatible group.

Cardiomyopathies, disorders of the heart muscle, represent a second condition requiring transplantation in infants.

Heart function deteriorates until the only option is transplantation. In the study, 11 percent of the incompatible recipients had cardiomyopathy versus 29 percent in the compatible group.

One key reason incompatible transplantation works in infants is the role of antibodies known as isohemagglutinins.

Until age 12 to 14 months, infants have immature immune systems with little or no production of these antibodies. That means they will not have pre-formed antibodies against the donor heart, lowering the risk of rejection.

Vricella said the most challenging transplants are in infants born with structural heart disease, congenital heart anomalies. These infants are being transplanted as a re-operation, which involves conversion of their anatomy to normal so that they can accommodate the donor heart, he said.

Vricella said that successful infant heart transplantation means an infant can go home and have a great quality of life.


'/>"/>

Contact: Karen Astle
karen.astle@heart.org
214-706-1392
American Heart Association
Source:Eurekalert

Related medicine news :

1. Nicotine in breast milk disrupts infants sleep patterns
2. Shaking may cause brain damage and serious long-term effects to infants
3. Maternal depression and controlling behavior associated with increased stress response in infants
4. Repeat steroids to premature infants linked to cerebral palsy
5. Babies raised in bilingual homes learn new words differently than infants learning one language
6. Joint Center Says New Approach Required to Reduce Black Infant Mortality
7. After Infant Gripe Water Recall Scare, Homeopathic Medicine Offers Safe Alternative
8. Vaginal progesterone gel may improve infant outcomes and...
9. Research shows how genetic mutation causes epilepsy in infants
10. Combination vaccines okay for infants, study shows
11. New York Citys infant mortality rate declined in 2006
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, a ... Miami, and Raleigh regions, is organizing an extended charity drive to benefit the ... chromosome abnormality. , After struggling since birth with several health challenges, T.J. was ...
(Date:10/13/2017)... Pa. (PRWEB) , ... October 13, 2017 , ... While ... dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. ... to medication in darkness or restricted lighting. As such, it eliminates the need to ...
(Date:10/13/2017)... Las Vegas, Nevada (PRWEB) , ... October 13, 2017 , ... ... of 7® Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum ... CBD dose required and providing a CBD form that can be easily incorporated into ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... New York, NY (PRWEB) , ... October 13, 2017 , ... ... most influential people in business to advocate for action towards gender equality at their ... 18,000 views from around the globe, and reached a social audience of over 3 ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017  According to the Centers for Disease Control and ... October . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the ... certain health insurance regulations. ... time to get a flu shot is by the end of October, ...
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
(Date:10/2/2017)... 2, 2017  AllianceRx Walgreens Prime, the combined central ... and pharmacy benefit manager Prime Therapeutics LLC (Prime), today ... included the unveiling of new signage at its headquarters ... as at a few other company-owned facilities across the ... patients, some of whom will begin to see the ...
Breaking Medicine Technology: