Navigation Links
Blood flows differently through the brains of schizophrenic patients
Date:5/25/2010

OAK BROOK, Ill. Researchers in Germany have used a magnetic resonance imaging (MRI) technique called continuous arterial spin labeling (CASL) to map cerebral blood flow patterns in schizophrenic patients quickly and without using radiation or contrast agents. Their findings appear in the online edition and July printed issue of the journal Radiology.

"Arterial spin labeling is a powerful technique that can help reduce the cost and complexity of examinations," said the study's lead author, Lukas Scheef, M.D., from the Department of Radiology at University of Bonn, Germany. "It can also be more readily repeated than methods that involve the use of contrast agents and radiotracers."

Schizophrenia is a chronic and severe brain disorder that affects approximately 2.4 million American adults, according to the National Institute of Mental Health. Symptoms can include hallucinations, delusions, disordered thinking, movement disorders, social withdrawal and cognitive deficits.

In the study, conducted at the University Hospital of Bonn in Germany, researchers used CASL MRI to compare cerebral blood flow in 11 non-medicated patients with schizophrenia and 25 healthy controls. The patient group included three women with a mean age of 36 years and eight men with a mean age of 32 years. The control group included 13 women (mean age, 29 years) and 12 men (mean age, 30 years).

The results revealed that compared to the healthy controls, the schizophrenic patients had extensive areas of hypoperfusion, or lower blood flow than normal in the frontal lobes and frontal cortex, anterior and medial cingulate gyri, and parietal lobes. These regions are associated with a number of higher cognitive functions including planning, decision making, judgment and impulse control.

Hyperperfusion, or increased blood flow, was observed in the cerebellum, brainstem and thalamus of the schizophrenic patients.

"Our CASL study revealed patterns of hypo- and hyperperfusion similar to the perfusion patterns observed in positron emission tomography (PET) and single photon emission computed tomography (SPECT) studies of schizophrenic patients," Dr. Scheef said.

Unlike PET and SPECT studies, CASL MR images can be quickly acquired without the use of ionizing radiation or contrast agents. In CASL MRI, arterial blood water is magnetically labeled in order to non-invasively measure cerebral blood flow.

"CASL MRI may allow researchers to gain a better understanding of schizophrenia," Dr. Scheef said. "In the long run, it may help to individualize and optimize treatment."


'/>"/>

Contact: Linda Brooks
lbrooks@rsna.org
630-590-7762
Radiological Society of North America
Source:Eurekalert

Related medicine news :

1. Report Finds Control of High Blood Pressure Improving
2. Frequent Doctor Visits Help Diabetics Control Blood Pressure
3. Fewer Sugary Drinks, Less High Blood Pressure
4. A new cancer vaccine starves tumors of blood
5. Online Program Helps Patients Self-Monitor Blood Pressure
6. Home monitoring, Web-based tool improves blood pressure control
7. New blood test for newborns to detect allergy risk
8. AeroClinic to Provide Free Blood Pressure Screenings at PHL Beginning May 20
9. Drug in new class of targeted therapies shows early promise against blood-related cancers
10. Elderly Falls Linked to Altered Blood Flow in Brain
11. Scripps Blood & Marrow Transplant Program Celebrates 30th Anniversary of Providing Life-Saving Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2016)... ... December 05, 2016 , ... Airy Jeanine is putting ... Songwriter-Producer Corey “Chorus” Gibson who has worked on hits by mega-artists like Rihanna, ... https://twitter.com/coreychorus , The sessions taking place in North Jersey’s Cybertime Studios ...
(Date:12/5/2016)... ... ... Shah MD, MBA has joined the Retina Group of New York (RGONY) specializing ... M. Maisel, MD and has been providing tertiary medical and surgical retinal care on Long ... expectations amongst her peers. Growing up in a family of doctors, Dr. Shah emulated ...
(Date:12/5/2016)... San Diego, CA (PRWEB) , ... December 05, 2016 , ... ... have seen and heard the dangers and downsides of patients who do not do ... devices. The field of cosmetic dermatology is in the midst of a renaissance and ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... won "Best Surgical Facial Rejuvenation" at the 2016 Anti-Aging & Beauty Awards ... , The Aesthetic & Anti-aging Medicine European Congress (AMEC) brings together ...
(Date:12/5/2016)... Columbus, OH (PRWEB) , ... December 05, 2016 ... ... novel engineering solution called the CardioQuick Patch® significantly improves the reproducibility and accuracy ... usability in various healthcare settings. , Over the last 60 years, studies ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec 5, 2016 Research and Markets ... Market - Global Forecast to 2021" report to their offering. ... , , ... reach 17.27 billion by 2021, at a CAGR of 5.3% from 2016 ... growing number of obesity cases, increasing government spending on healthcare, and rising ...
(Date:12/5/2016)... PharmaBoardroom today releases its new 70 page Switzerland Healthcare & Life ... , , ... stakeholders crucial insight into Switzerland ; a country located ... of the world,s most important international health institutions as well as two ... number one ranking globally in terms of ease of doing business and ...
(Date:12/4/2016)... , Dec. 4, 2016 Blueprint ... in discovering and developing targeted kinase medicines for ... from its ongoing Phase 1 trial evaluating BLU-285, ... with advanced systemic mastocytosis (SM). Blueprint Medicines is ... of D816V mutant KIT. Approximately 90 to 95 ...
Breaking Medicine Technology: