Navigation Links
Blood and saliva tests help predict return of HPV-linked oral cancers
Date:7/31/2014

Physicians at Johns Hopkins have developed blood and saliva tests that help accurately predict recurrences of HPV-linked oral cancers in a substantial number of patients. The tests screen for DNA fragments of the human papillomavirus (HPV) shed from cancer cells lingering in the mouth or other parts of the body. A description of the development is published in the July 31 issue of JAMA Otolaryngology Head & Neck Surgery.

"There is a window of opportunity in the year after initial therapy to take an aggressive approach to spotting recurrences and intensively addressing them while they are still highly treatable," says Joseph Califano, M.D., professor of Otolaryngology - Head and Neck Surgery, member of the Johns Hopkins Kimmel Cancer Center, and medical director of the Milton J. Dance Jr. Head and Neck Center at the Greater Baltimore Medical Center. "Until now, there has been no reliable biological way to identify which patients are at higher risk for recurrence, so these tests should greatly help do so," he adds.

Patients with HPV-associated oropharyngeal cancers are generally examined every one to three months in the first year after diagnosis. Recurrences are often found when patients report ulcers, pain or lumps in the neck. But imaging tests are unreliable in detecting cancer recurrence earlier, and the location of oropharyngeal cancers in the tonsils, throat and base of the tongue -- make it difficult for physicians to spot budding lesions.

Califano says survival rates for patients with early-stage, HPV-related oral cancers are as high as 90 percent within the first two years, and a study reported by Johns Hopkins experts in February showed that, even after recurrence, more than 50 percent of patients survive two years after their recurrence. The new blood and saliva tests have the potential to improve these rates, he adds.

For the study, the Johns Hopkins team analyzed blood and saliva samples from 93 oropharyngeal cancer patients who were treated with surgery, radiation alone, or combined chemotherapy and radiation at The Johns Hopkins Hospital or Greater Baltimore Medical Center. Samples were collected before and after treatment. Some 81 patients had HPV-positive tumors. The researchers selected patients with a variety of early-to-advanced stage cancers; none of the patients had distant metastasis.

The blood and saliva tests were performed using polymerase chain reaction, which amplifies certain portions of DNA and measures its amount.

The scientists found that HPV DNA detected in patients' saliva after treatment was predictive for recurrence nearly 20 percent of the time in a subset of the patients. When the scientists looked for HPV DNA in the blood of another subset of patients, the accuracy of a recurrence prediction rose to more than 55 percent. In a third subset of patients, finding HPV DNA in both blood and saliva samples after treatment accurately predicted recurrence 70 percent of the time.

Despite the encouraging results, Califano says, further refinements are still badly needed to improve detection of possible recurrences because HPV is highly prevalent in our bodies, and "we can't be sure our test results are cancer-specific and not due to other forms of HPV infection or exposure."

His team is looking for other genomic biomarkers that would increase the specificity of HPV DNA testing in blood and saliva. Califano also cautioned that the current study was too small to link test results to the severity of recurrence.

Rates of HPV-related oropharyngeal cancer are on the rise in the United States, outpacing oropharyngeal cancers due to tobacco and alcohol use, according to Califano. Some 70 percent of nearly 30,000 oropharyngeal cancers diagnosed in the U.S. are caused by HPV.


'/>"/>

Contact: Vanessa Wasta
wasta@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Related medicine news :

1. Drug target identified for common childhood blood cancer
2. Breakthrough in understanding of important blood protein
3. Restore My Blood Sugar Review Reveals Exclusive Ways to Normalize Blood Sugar
4. Could a Blood Test Predict Suicide Risk?
5. Blood Test Might Help Prevent Certain Birth Defects
6. Study Finds Common Blood Protein May Predict Mesothelioma Survival, Reports Surviving Mesothelioma
7. A blood test for suicide?
8. Professor Develops Blood Test for Alzheimer’s Disease Risk
9. Study tracks worldwide spread of beneficial blood cell gene variant
10. Preemies May Have Higher Risk of Blood Clots, Even as Adults
11. Potential universal blood test for cancer discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2017)... ... February 28, 2017 , ... ... in North America for the scientific development, healthcare training and clinical application of ... & Scientific Session on September 16-17 in Greenville, SC at the Bon Secours ...
(Date:2/28/2017)... , ... February 28, 2017 , ... ... Inc., a healthcare automation intelligence company based in New York. , “Ensuring an ... the provider’s workflow remains unaltered. Those two fundamental reasons are the reasons this ...
(Date:2/27/2017)... ... February 27, 2017 , ... It’s ... strength, which often leads to a host of health issues, including urinary incontinence. ... Geriatrics Society discovered that good overall muscle strength in older women, particularly ...
(Date:2/27/2017)... ... February 27, 2017 , ... The threat of nuclear warfare ... for a company involved in the underground testing of nuclear weapons. Years later, when ... Expendable Workers of the Cold War Nuclear Testing,” Clayton exposes the critical decisions made ...
(Date:2/27/2017)... ... February 27, 2017 , ... POUGHKEEPSIE, N. Y. – Peer-reviewed guidelines ... despite scientific studies, the Center for Disease Control ( CDC ) and Infectious Diseases ... Kenneth B. Liegner, M.D. has compiled into a single volume a compelling argument that ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... , Feb. 27, 2017   Royal ... PHIA), a global leader in health technology, today ... Drug Administration (FDA) to market its ElastQ Imaging ... family of ultrasound systems. ElastQ Imaging enables simultaneous ... which is essential for the diagnosis of various ...
(Date:2/27/2017)...  Infinity Pharmaceuticals, Inc. (NASDAQ: INFI ) ... th Annual Healthcare Conference on Monday, March 6, ... MA. A live webcast of Infinity,s presentation ... website at www.infi.com , and will be available ... Infinity,Infinity is an innovative biopharmaceutical company dedicated to advancing ...
(Date:2/27/2017)... February 27, 2017 A recent research report ... marijuana market alone is expected to reach a value of $55.8 ... along with 28 states have legalized marijuana for medical uses. ... Florida , North Dakota , ... approved to use the drug in medical applications such as chemotherapies ...
Breaking Medicine Technology: