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Blood Type O Associated With Less Risk for Heart Attack
Date:1/15/2011

By Steven Reinberg
HealthDay Reporter

FRIDAY, Jan. 14 (HealthDay News) -- Researchers have simultaneously discovered a gene that seems to raise the risk of cardiovascular disease, while also noting that having the blood type O might guard against heart attack once arteries become clogged.

"Certain genes predispose to heart artery plaque build-up, whereas different genes lead to heart attack when you already have plaque build-up," said study author Dr. Muredach P. Reilly, an associate professor of medicine at the Cardiovascular Institute of the University of Pennsylvania.

One of the more heart-protective genes also helps direct people to have type O blood, the team reported.

The study suggests the multifaceted relationship between genetics and cardiovascular health, Reilly said. "Not all genes for heart disease are equal and therefore have to be used differently in new treatments for heart disease and when assessing risk of heart disease," he said.

The report is published in the Jan. 15 online edition of The Lancet.

For the study, Reilly's team compared almost 13,000 people with coronary artery disease against almost 7,400 people who did not have the condition.

And to hone in on specific genes that might play a role in heart attacks, they compared about 5,800 people with coronary artery disease who had had a heart attack with more than 3,600 people who had coronary artery disease but had never had a heart attack.

Using this method, Reilly's group identified a new gene called ADAMTS7, which was associated with an increased risk of coronary artery disease.

And in the analysis specific to heart attack, they also found an association between blood type and the risk for heart attacks.

Specifically, the gene that makes people have blood type O also protects them from heart attacks, the researchers explained.

Blood is classified as ABO, with eight possible types, determi
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