Navigation Links
Blood Test Shows Statistically Significant Association With Alzheimer's Disease (AD), May Predict Conversion of Mild Cognitive Impairment to AD
Date:7/16/2009

LONDON, BIRMINGHAM, England and VIENNA, July 16 /PRNewswire/ -- Dr. Zsuzsanna Nagy of the University of Birmingham today presented data from a clinical study, funded by Cytox Limited, demonstrating that a simple blood-based biomarker discriminated between patients with Alzheimer's disease (AD) and control subjects. The findings were statistically highly significant, and the test discriminated between the two groups with 80% sensitivity and 80% specificity. The results also showed that 40% of the mild cognitive impairment (MCI) patients tested had the same test results as AD patients. Follow up study of MCI patients enrolled in an earlier study found that the test allowed early identification of those MCI patients who later developed dementia. The results were presented at the 2009 Alzheimer's Association International Conference on Alzheimer's Disease (ICAD 2009), held in Vienna, Austria.

The blood test measures the integrity of the cell cycle G1/S restriction point in peripheral blood lymphocytes. Dr. Nagy, the inventor of the test and scientific co-founder of Cytox Ltd, was the principal investigator of the study, which was conducted in collaboration with the Oxford Project to Investigate Memory and Aging (OPTIMA). According to Dr. Nagy, "The results of this study support the cell cycle hypothesis of Alzheimer's disease - specifically, that G1/S cell cycle regulatory failure leads to the downstream development of the characteristic pathologies of the disease, the amyloid plaques and tau tangles. Most importantly, the findings validate the use of our lymphocyte test as a biomarker of Alzheimer's disease and suggest that the test is predictive of cognitive deficit developing in MCI patients."

About University of Birmingham

The University of Birmingham is a world leading research-led institution and member of the elite Russell group of universities. Expertise within its five Colleges includes Medicine and Dentistry, Engineering and Physical Sciences, Life and Environmental Sciences, Social Sciences and Arts and Law. The University was one of the first civic universities, receiving its Royal Charter in 1900, and is one of the largest in the UK, with 27,000 students. The University of Birmingham is consistently ranked as a top UK university with a world presence and counts eight Nobel Prize winners amongst alumni and staff. According to the recent independent UK Research Assessment Exercise, nearly 90% of the University of Birmingham's research activity has international impact.

About Cytox Limited

Cytox is a UK company developing products and services for neurodegenerative disorders. The company provides biomarker services to pharmaceutical industry clients conducting clinical trials with drugs for the treatment of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Cytox's blood tests enable the prediction of which patients with MCI will develop AD. The biomarkers are based on the cell cycle hypothesis of AD and were invented by Dr. Zsuzsanna Nagy at the University of Oxford and the University of Birmingham. For more information about Cytox, please visit the web site at http://www.cytoxgroup.com/.


'/>"/>
SOURCE Cytox Limited
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Dr. David Williams Featured on Searchbloodsugar.com
2. Life-Saving Thermal Angel Blood Warmer Is Immediately Available For Use By U.S. Troops In Harms Way
3. Leading Blood Centers, LifeSource and Central Blood Bank, Spotlight a Unique Donor Population During National Hereditary Hemochromatosis Awareness Month
4. Blood Rush to the Brain When Angry Is a Good Sign
5. Cord Blood America Hires Management Team for Its New Stem Cell Laboratory
6. Blood vessel bends and branches put the brakes on statins
7. Pioneer of Digital Place-Based Media Joins World's Leading Blood Pressure and Health Kiosk Manufacturer
8. Cord Blood America Leases Las Vegas Building for Its Own Stem Cell Laboratory
9. Vegetable Amino Acid Lowers Blood Pressure
10. Intensive management can improve blood pressure in non-adherent hypertensive patients
11. Women's Health Expert Dr. Susan Lark Featured on Searchbloodsugar.com
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... Petersburg Florida (PRWEB) , ... March 28, 2017 , ... ... Marine Corp to raise money to for the Toys for Tots Literacy Campaign at ... federal budget in excess of $70 billion, the U.S. ranks at number 14 internationally ...
(Date:3/28/2017)... ... March 28, 2017 , ... AutismOne announced ... American Association of Integrative Medicine and available for application on Saturday, May 27, ... 2017 Conference in Colorado Springs. , Ed Arranga, president of AutismOne, stated: "Many ...
(Date:3/28/2017)... ... March 28, 2017 , ... The ... in Atlantic City March 13-16, was a busy spot this year. Liz Solovay ... discussed strategies for preventing outbreaks among camp communities during the upcoming 2017 camping ...
(Date:3/28/2017)... ... ... a common and unwelcomed occurrence in people of all ages, genders and ethnicities. Dermatologist Dr. ... of dealing with excess skin oil. “Oily skin is a challenge to many of my ... the oily shine while keeping the skin fresh and clean,” says Dr. Au. , What ...
(Date:3/28/2017)... ... ... thrilling adventure that reveals the mystery of Kevin’s purpose. “A Prophets Bones” is the creation ... asked of him that he had neglected to do, but this was from God and ... some who would have felt themselves to be special and better than others due to ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... BOSTON , March 28, 2017 /PRNewswire/ ... today announced a partnership with premium news ... allows pharmaceutical companies to extract key insights from ... text mining technology. The Linguamatics I2E ... top 20 global pharmaceutical companies. The Linguamatics-Dow Jones ...
(Date:3/28/2017)...  Akcea Therapeutics, a subsidiary of Ionis Pharmaceuticals, Inc. (NASDAQ: ... directors: Christopher Gabrieli , ... as chairman of the board of Akcea Therapeutics. ... Forest Laboratories. Sandford D. Smith , ... "We are excited to announce this expansion to our ...
(Date:3/28/2017)... RXi Pharmaceuticals Corporation (NASDAQ: RXII), a ... significant unmet medical needs, today announced that it ... Office (JPO) for the composition of matter of ... the treatment or prevention of fibrotic disorders, including ... retinopathy (Japanese Patent #: 6060071).  This patent includes ...
Breaking Medicine Technology: