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Blood Test Might Spot Pancreatic Cancer Early, Study Finds
Date:3/29/2013

e cancerous tumor can be removed, it's usually too late, he said. By the time the cancer is detected, even in the early stage suggested by their test, the cancer has most likely spread beyond the pancreas, D'Olimpio pointed out.

"The test is able to detect cancer when it is at stage 1, but it's a fatal disease once it gets past stage 0," D'Olimpio said. (Staging, which refers to the severity of a person's cancer, usually runs from 0 to 4.)

"The cure rates of these patients is still going to be less than 20 percent," he said.

For the study, published online March 29 in Cancer Epidemiology, Biomarkers & Prevention, the researchers used a technology called gas chromatography mass spectrometry to analyze the blood from study participants.

The researchers randomly assigned 43 pancreatic cancer patients and 42 healthy participants to what they called a training set, where they made their initial findings. To validate their findings, they also tried the test on 42 patients with pancreatic cancer, 41 healthy people and 23 people with chronic pancreatitis (inflammation of the pancreas).

The researchers found 18 metabolites that were significantly different in patients with pancreatic cancer, compared with the healthy patients.

They refined their test using four metabolites to identify patients with pancreatic cancer.

The test had a sensitivity of 71.4 percent and a specificity of 78.1 percent when it was used with patients with pancreatic cancer and patients with chronic pancreatitis, the researchers reported. Sensitivity measures the accuracy of the test in identifying people with pancreatic cancer and specificity measures the accuracy of the test in weeding out those who didn't have the disease. Chronic pancreatitis is sometimes mistaken for cancer, so cutting down false positives is important.

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