Navigation Links
Blood Test Might Spot Pancreatic Cancer Early, Study Finds
Date:3/29/2013

By Steven Reinberg
HealthDay Reporter

FRIDAY, March 29 (HealthDay News) -- A new blood test that detects deadly pancreatic cancer earlier than usual might slightly improve patients' odds for survival, a small Japanese study suggests.

"This new diagnostic test may be a safe and easy screening method that could improve the prognosis of patients with pancreatic cancer through earlier detection," said lead researcher Dr. Masaru Yoshida, an associate professor in the division of metabolomics research at Kobe University Graduate School of Medicine. "A drop of blood contains a lot of information."

Currently, the 5-year survival rate for pancreatic cancer is less than 5 percent, largely because the cancer usually has spread by the time it is detected.

The new approach relies on metabolomics technology, an emerging science that focuses on small molecules. The blood test measures byproducts of metabolism, called metabolites, found in the blood.

By looking for differences between the levels of metabolites in patients with and without pancreatic cancer, the researchers are able to identify those with cancer.

Finding pancreatic cancer earlier means more patients can have the tumor removed and live longer than most patients do now, Yoshida noted.

"Conventional tests using blood or imaging are not appropriate for pancreatic cancer screening and early detection, so new screening and diagnostic methods for pancreatic cancer are urgently required," Yoshida said.

Currently, in more than 80 percent of cases of pancreatic cancer, the cancer has metastasized, or spread, making it inoperable, he explained.

One expert doesn't think this test is a breakthrough.

"It's an improvement, but not a breakthrough," said Dr. James D'Olimpio, director of supportive oncology at North Shore-LIJ Cancer Institute in Lake Success, N.Y.

"The problem is it's not early enough," he said.

Even if the cancerous tumor can be removed, it's usually too late, he said. By the time the cancer is detected, even in the early stage suggested by their test, the cancer has most likely spread beyond the pancreas, D'Olimpio pointed out.

"The test is able to detect cancer when it is at stage 1, but it's a fatal disease once it gets past stage 0," D'Olimpio said. (Staging, which refers to the severity of a person's cancer, usually runs from 0 to 4.)

"The cure rates of these patients is still going to be less than 20 percent," he said.

For the study, published online March 29 in Cancer Epidemiology, Biomarkers & Prevention, the researchers used a technology called gas chromatography mass spectrometry to analyze the blood from study participants.

The researchers randomly assigned 43 pancreatic cancer patients and 42 healthy participants to what they called a training set, where they made their initial findings. To validate their findings, they also tried the test on 42 patients with pancreatic cancer, 41 healthy people and 23 people with chronic pancreatitis (inflammation of the pancreas).

The researchers found 18 metabolites that were significantly different in patients with pancreatic cancer, compared with the healthy patients.

They refined their test using four metabolites to identify patients with pancreatic cancer.

The test had a sensitivity of 71.4 percent and a specificity of 78.1 percent when it was used with patients with pancreatic cancer and patients with chronic pancreatitis, the researchers reported. Sensitivity measures the accuracy of the test in identifying people with pancreatic cancer and specificity measures the accuracy of the test in weeding out those who didn't have the disease. Chronic pancreatitis is sometimes mistaken for cancer, so cutting down false positives is important.

More information

For more information on pancreatic cancer, visit the American Cancer Society.

SOURCES: Masaru Yoshida M.D., Ph.D., associate professor, division of metabolomics research, Kobe University Graduate School of Medicine, Japan; James D'Olimpio, M.D., director, Supportive Oncology and the Palliative Care/Cancer Pain Center, North Shore-LIJ Cancer Institute, Lake Success, N.Y.; March 29, 2013, Cancer Epidemiology, Biomarkers & Prevention, online


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. OneBlood Partners with BloodHub for Supply Chain Automation
2. Online Program developed by Professional Nutrition Therapists Offers Hope to Millions for Getting Blood Sugars under Control Right from the Comfort of Home
3. GW professor researching ways to improve human tissue dissection, reduce blood transfusions
4. Researchers decode biology of blood and iron disorders mapping out novel future therapies
5. Reversing blood and freshening it up
6. Diet Can Lower Blood Pressure As Much As Taking A Medication, From The March 2013 Harvard Men's Health Watch
7. NuvaRing Blood-Clotting Claims Now Being Investigated by Resource4thePeople Attorneys
8. New method developed to expand blood stem cells for bone marrow transplant
9. Blacks More Likely to Get Amputations Due to Blocked Blood Flow: Study
10. UC Davis research advances efforts to prevent dangerous blood clots
11. PCL Alverno Laboratories Launches Blood Test to Aid in the Early Detection of Lung Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blood Test Might Spot Pancreatic Cancer Early, Study Finds
(Date:2/12/2016)... ... February 12, 2016 , ... Coco Libre, the maker of coconut water ... LA GRAMMY’s Style Lounge Event. Coco Libre will offer musicians and celebrities the company’s ... big event. The invitation-only gifting suite, held this year at the W Hollywood Hotel, ...
(Date:2/12/2016)... ... February 12, 2016 , ... Fisher House Foundation Chairman and ... J. Lee, Nevada Military Support Alliance president Scott Bensing, and Peggy Kearns Director, VA ... Southern Nevada Healthcare System. This will be the first Fisher House in Nevada, ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... Pittsburgh metro area, celebrates the beginning of the latest charity campaign in their ... skills through art. Donations to this worthy cause are currently being accepted at: ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... Care.” , The print component of “Revolutionizing Cancer Care” is distributed ... York, Washington DC/Baltimore, and Seattle, with a circulation of approximately 250,000 copies and ...
(Date:2/12/2016)... Highlands Ranch, Colo. (PRWEB) , ... February 12, 2016 , ... ... particularly over the past 35 years. A president has access to health and wellness ... leader of the free world, no single individual has a schedule as frenetic as ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Feb. 12, 2016  Sequent Medical, Inc. announced today ... to evaluate the safety and effectiveness of the WEB™ ... ruptured intracranial aneurysms.  Prof Laurent Spelle , MD, ... Paris, France and Principal Investigator of ... France and Germany.  Although patients with ...
(Date:2/12/2016)... , Feb. 12, 2016  Aralez Pharmaceuticals Inc. (Nasdaq: ... announced the Company will ring the Nasdaq Closing Bell ... New York at 4:00 p.m. ET on ... Aralez. Adrian Adams , will perform ... 3:50 to 4:00 p.m. ET.  A live webcast will ...
(Date:2/12/2016)... February 12, 2016 ... auf den ungedeckten medizinischen Bedarf bei Lungen- ... seines klinischen Forschungsprogramms bekannt. Das Programm, das ... Verbesserungen ihrer respiratorischen Funktionen und anderer klinischer ... ein Medizintechnikunternehmen, das sich auf den ungedeckten ...
Breaking Medicine Technology: