Navigation Links
Blood Stem Cells Originate in the Placenta
Date:3/7/2008

Finding may help scientists recreate this microenvironment for disease treatments

FRIDAY, March 7 (HealthDay News) -- Blood stem cells, which later differentiate into all types of blood cells, originate and are nurtured in the placenta, a U.S. study finds.

This finding may help researchers replicate the specific embryonic microenvironment necessary to grow blood stem cells in the lab so doctors can treat patients with diseases such as leukemia and aplastic anemia, said senior author Dr. Hanna Mikkola, a researcher in the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at the University of California, Los Angeles (UCLA).

"It was a big mystery, where these cells originated. This is the first time we can really say definitively that blood stem cells are generated in the placenta. There's no more speculation," Mikkola said in a prepared statement.

The discovery, reported in the March 6 issue of Cell Stem Cell, was made in research with mice. The researchers are now working to replicate it in humans.

"If we want to fully harness the potential of embryonic stem cells to treat disease, it's critical for us to learn how to make tissue-specific stem cells. We can learn that by studying what happens during embryonic development," said Mikkola, an assistant professor of molecular, cell and developmental biology and a researcher at UCLA's Jonsson Comprehensive Cancer Center.

In previous research, Mikkola and her colleagues found the placenta contained a large supply of stem cells, but the researchers weren't sure if these stem cells were created in the placenta or originated elsewhere and migrated to the placenta to self-renew.

In this new study, Mikkola's team examined a unique mouse model, a mouse embryo without a heartbeat. Because there was no blood circulation, the researchers were able to find the blood stem cells at their point of origin in the placenta.

"Using this model, we identified that the placenta has the potential to make hematopoietic [blood] stem cells with full differentiation ability to create all the major lineages of blood cells. The placenta acts as a sort of kindergarten for these newly made blood stem cells, giving them the first education they need," Mikkola explained.

More information

The National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: University of California, Los Angeles, news release, March 6, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Specific antagonism lowers blood pressure
2. Restricting Blood Flow May Help Heart Bypass Patients
3. FDA Updates Prescription Guidelines for Blood Thinner
4. Doctors Often Miss High Blood Pressure in Kids
5. Back to School Means Return of School Blood Drives
6. Blood-flow detector software show promise in preventing brain damage
7. FDA Approves New Roche West Nile Virus Blood Screening Test
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Laser blasts viruses in blood
10. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
11. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blood Stem Cells Originate in the Placenta
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association ... Featuring a collection of specialty vendors and unique items from across the nation, this ... health and wellness services offered by the VNA. The boutique will be open ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
(Date:9/27/2017)... -- Commended for their devotion to personalized service, SMP Pharmacy Solutions ... in the South Florida Business Journal,s 50 Fastest-Growing Companies, and ... the national specialty pharmacy has found its niche.  To that ... be honored by SFBJ as the 2017 Power Leader in ... receive his award in October, Bardisa said of the three ...
(Date:9/25/2017)... 25, 2017   Montrium , an industry ... today—from the IQPC Trial Master Files & Inspection ... that EastHORN Clinical Services has selected eTMF ... TMF management. EastHORN, a leading European contract research ... increase transparency to enable greater collaboration with sponsors, ...
Breaking Medicine Technology: