Navigation Links
Blood Pressure Pill Combo More Effective Than Diuretics
Date:12/3/2008

Study suggests need to change therapeutic guidelines,,,,

WEDNESDAY, Dec. 3 (HealthDay News) -- A pill that contains two blood pressure drugs was more effective than a diuretic-based strategy in reducing the risk of serious cardiovascular problems and death in people with high blood pressure, according to a study that included more than 11,000 patients in the United States, Sweden, Norway, Denmark and Finland.

The patients took either a tablet containing benazepril (an ACE inhibitor) and amlodipine (a calcium channel blocker) or a tablet that contained benazepril and hydrochloro-thiazide, a type of diuretic (water pill). Both combination pills helped reduce blood pressure in more than 75 percent of patients, but those taking the first pill had 20 percent fewer cardiovascular events than those taking the other combination pill with the diuretic. The study defined cardiovascular events as cardiovascular deaths, heart attacks, strokes, hospitalization for unstable angina, and treatments to reopen blocked heart arteries.

The Avoiding Cardiovascular Events Through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) study was published in the Dec. 4 issue of the New England Journal of Medicine.

The results were so significant that the trial was stopped early, said the authors of the study, which was funded by Novartis, one of the companies that offer two-drug tablets for treatment of high blood pressure. The researchers said the findings suggest the need to change current blood pressure control guidelines, which call for initial treatment with a diuretic, with other drugs added only as needed to lower blood pressure.

"This robust study showed us that switching patients to a single-pill combination meant that twice as many patients got to their blood pressure goal, regardless of previous therapy," study leader Dr. Kenneth Jamerson, a professor of internal medicine at the University of Michigan Medical School and a member of the U-M Cardiovascular Center, said in a university news release.

"The significant reduction in cardiovascular events we observed in patients will, I hope, show physicians that earlier use of a combination medicine, especially with amlodipine, may be in the best interest of the patients," Jamerson said.

As many as 73 million Americans have high blood pressure, which increases the risk of stroke, heart attack, heart failure and other health problems. Drugs can help control blood pressure, but many patients have trouble taking the multiple medications they need, which is why combination pills were developed, according to background information in the news release about the study.

More information

The American Heart Association has more about blood pressure-lowering drugs.



-- Robert Preidt



SOURCE: University of Michigan Health System, news release, Dec. 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. UCLA scientists prove endothelial cells give rise to blood stem cells
2. Global Med Technologies(R) European Subsidiary to Provide Strategic Blood Transfusion Software for 21 Paris Hospitals
3. Stanford blood scanner detects even faint indicators of cancer
4. Older Adults Who Exercise Boost Blood Flow in Brain
5. Preemies Low Blood Pressure Linked to SIDS
6. Potassium loss from blood pressure drugs may explain higher risk of adult diabetes
7. Continuous Blood Pressure Monitoring Predicts Risks
8. Gulf Coast Hospital Chooses Global Med Technologies(R) Blood System
9. High Blood Pressure Stalks Many Americans
10. New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes
11. A simple blood test for colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blood Pressure Pill Combo More Effective Than Diuretics
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: ... “America On The Brink” is the creation of published author, William Nowers. ... As a WWII veteran, he spent thirty years in the Navy. Following ...
(Date:10/12/2017)... WAUSAU, Wis. (PRWEB) , ... October 12, 2017 ... ... formulated standard products to meet the demand of today’s consumer and regulatory authorities ... team of probiotic experts and tested to meet the highest standard. , ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
(Date:10/12/2017)... ... 12, 2017 , ... On Saturday, October 21, the Health & Wellness Center ... to raise money for the American Heart Association Heart Walk. Teams of up to ... together to keep their treadmills moving for 5 hours. Treadmills will start at 7:00 ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... latest in wound care advancements to physician colleagues, skilled nursing facility medical directors ... "Navigating the Treacherous Waters of Wound Care." , "At many of these conferences ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... Oct. 5, 2017  In response to the ... and Maxillofacial Surgeons (AAOMS) released prescribing recommendations that ... be used as a first-line therapy to manage ... Recognizing the value and ... Paper "Opioid Prescribing: Acute and Postoperative Pain Management" ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans Bioscience ... the use of wearable and home sensors for real-time ... Early Signal Foundation, a nonprofit organization focused on disruptive ... provide an affordable analytical system to record and integrate ... ...
Breaking Medicine Technology: