Navigation Links
Blood Pressure Pill Combo More Effective Than Diuretics
Date:12/3/2008

Study suggests need to change therapeutic guidelines,,,,

WEDNESDAY, Dec. 3 (HealthDay News) -- A pill that contains two blood pressure drugs was more effective than a diuretic-based strategy in reducing the risk of serious cardiovascular problems and death in people with high blood pressure, according to a study that included more than 11,000 patients in the United States, Sweden, Norway, Denmark and Finland.

The patients took either a tablet containing benazepril (an ACE inhibitor) and amlodipine (a calcium channel blocker) or a tablet that contained benazepril and hydrochloro-thiazide, a type of diuretic (water pill). Both combination pills helped reduce blood pressure in more than 75 percent of patients, but those taking the first pill had 20 percent fewer cardiovascular events than those taking the other combination pill with the diuretic. The study defined cardiovascular events as cardiovascular deaths, heart attacks, strokes, hospitalization for unstable angina, and treatments to reopen blocked heart arteries.

The Avoiding Cardiovascular Events Through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) study was published in the Dec. 4 issue of the New England Journal of Medicine.

The results were so significant that the trial was stopped early, said the authors of the study, which was funded by Novartis, one of the companies that offer two-drug tablets for treatment of high blood pressure. The researchers said the findings suggest the need to change current blood pressure control guidelines, which call for initial treatment with a diuretic, with other drugs added only as needed to lower blood pressure.

"This robust study showed us that switching patients to a single-pill combination meant that twice as many patients got to their blood pressure goal, regardless of previous therapy," study leader Dr. Kenneth Jamerson, a professor of internal medicine at the University of Michigan Medical School and a member of the U-M Cardiovascular Center, said in a university news release.

"The significant reduction in cardiovascular events we observed in patients will, I hope, show physicians that earlier use of a combination medicine, especially with amlodipine, may be in the best interest of the patients," Jamerson said.

As many as 73 million Americans have high blood pressure, which increases the risk of stroke, heart attack, heart failure and other health problems. Drugs can help control blood pressure, but many patients have trouble taking the multiple medications they need, which is why combination pills were developed, according to background information in the news release about the study.

More information

The American Heart Association has more about blood pressure-lowering drugs.



-- Robert Preidt



SOURCE: University of Michigan Health System, news release, Dec. 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. UCLA scientists prove endothelial cells give rise to blood stem cells
2. Global Med Technologies(R) European Subsidiary to Provide Strategic Blood Transfusion Software for 21 Paris Hospitals
3. Stanford blood scanner detects even faint indicators of cancer
4. Older Adults Who Exercise Boost Blood Flow in Brain
5. Preemies Low Blood Pressure Linked to SIDS
6. Potassium loss from blood pressure drugs may explain higher risk of adult diabetes
7. Continuous Blood Pressure Monitoring Predicts Risks
8. Gulf Coast Hospital Chooses Global Med Technologies(R) Blood System
9. High Blood Pressure Stalks Many Americans
10. New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes
11. A simple blood test for colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blood Pressure Pill Combo More Effective Than Diuretics
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
(Date:6/24/2016)... 2016  Collagen Matrix, Inc., ("Collagen Matrix") the ... of collagen and mineral based medical devices for ... Bill Messer has joined the company as ... the growing portfolio of oral surgery, neurosurgery, orthopaedic ... joins the Collagen Matrix executive team as an ...
(Date:6/24/2016)... , June 24, 2016 ... has announced the addition of the " Global ... This report ... provides an updated review, including its applications in various ... total market, which includes three main industries: pharmaceutical and ...
Breaking Medicine Technology: