Navigation Links
Blood Pressure Drug Might Work Against Alzheimer's
Date:10/25/2007

It prevents formation of beta-amyloid clumps in mice, study says

THURSDAY, Oct. 25 (HealthDay News) -- The blood pressure drug valsartan shows the ability to reduce Alzheimer's disease-like symptoms in mice, researchers report.

The potential value of valsartan, marketed as Diovan, emerged from a screening program that started with 55 high blood pressure drugs, said study author Dr. Giulio Maria Pasinetti, a professor of psychiatry and neurosciences at Mount Sinai School of Medicine in New York City.

"With screening in vivo [animal studies], we came up with seven candidates," Pasinetti said, adding that valsartan was the most promising of the lot.

Specifically, valsartan interfered with the formation of clumps of the protein beta-amyloid in the brains of mice genetically engineered to be susceptible to an Alzheimer's-like disease, Pasinetti said. Beta-amyloid deposits are a leading feature of Alzheimer's disease in humans.

"We also found that in this animal model, there was some kind of effect of valsartan even at doses that were threefold lower than the common equivalent doses given to patients with hypertension [high blood pressure]," he said.

The findings are published in the Oct. 26 issue of the Journal of Clinical Investigation.

Valsartan is a member of the family of angiotensin II blockers that are widely used to control high blood pressure. Other studies already have linked a related class of blood pressure drugs, called ACE inhibitors, to a reduced risk of Alzheimer's disease. Pasinetti said his group's research with mice has identified three other blood pressure drugs that have the same effect as valsartan. He did not identify the drugs, saying, "That will be the subject of another paper."

The next step with valsartan, Pasinetti said, will be "to develop a series of clinical studies to see if the same effect seen in mice can be replicated in humans."

Dr. Sam Gandy, chairman of the Alzheimer's Association's medical and scientific advisory council, said recent experiences with other medications have shown that such tests are essential, because the experimental therapies often don't pan out.

"This is another example of laboratory work on Alzheimer's disease testing existing drugs to see if they have activity," said Gandy, who's also director of Emory University's Center for Neurodegenerative Diseases. "We have been down this road with Epogen, with non-steroidal anti-inflammatory drugs; now we're going down the road with statins."

What's needed, he said, is "a real controlled clinical trial to see if it [valsartan] works. Just because it makes sense, and the evidence looks good, doesn't mean that it is going to work. The acid test is a clinical trial."

Gandy said he has become wary of reports such as the one from Pasinetti "because of our experience with estrogen." Early reports said the female sex hormone was highly promising as an Alzheimer's preventive treatment, but it failed in a controlled trial.

Panisetti said his group now is trying to determine the potential mechanism by which valsartan and the other drugs might work against Alzheimer's disease. "We are working primarily on the brain rather than on blood pressure," he said.

More information

To learn more about Alzheimer's, visit the Alzheimer's Association.



SOURCES: Giulio Maria Pasinetti, M.D., professor, psychiatry and neurosciences, Mount Sinai School of Medicine, New York City; Sam Gandy, M.D., chairman, Alzheimer's Association's medical and scientific advisory council, and director, Emory University Center for Neurocognitive Disease, Atlanta; Oct. 26, 2007, Journal of Clinical Investigation


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Recommendations for Treatment of Blood Pressue
2. Blood Cells Capable of Regenerating Liver
3. Infant receives first bloodless liver transplant
4. Spouses and other partners lower blood pressure says new research
5. H2O - a cure for low blood pressure
6. Uncontrolled blood pressure
7. Weight and Blood Pressure
8. Grandmother’s diet in pregnancy can affect grandchildren’s blood sugr
9. Early diagnosis for autism from blood tests may be possible
10. Antibiotic from crab blood indentified
11. Gum disease may be caused by blood clotting gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... , ... January 20, 2017 , ... “The Land of ... attention to the issue of world hunger, and shares the simple and achievable answer. ... devoted husband and member of the Fairview Missionary Church in Angola, Indiana where he ...
(Date:1/19/2017)... ... ... Today, the Centers for Medicare & Medicaid Services (CMS) announced over 359,000 clinicians ... Clinicians who participate in APMs are paid for the quality of care they give ... build a system that delivers better care and one in which clinicians work together ...
(Date:1/19/2017)... ... 19, 2017 , ... Next week after January 20th, the fear for many ... that circumvent health needs of over 30 million. Many interviews with Dr. Carol Francis ... government public servants were suppose to prioritize. Interviews provided below. , Among ...
(Date:1/19/2017)... LINCOLN, R.I. (PRWEB) , ... January 19, 2017 , ... With the cold weather here, ... sidewalks. , Snow blowers are efficient when clearing large amounts of snow, but they can ... tips from the U.S. Consumer Product Safety Commission for the proper use of snow blowers:, ...
(Date:1/19/2017)... ... January 19, 2017 , ... LabRoots , the ... around the world, announces the launch of its newly redesigned website. The sleek ... research breakthroughs and trending news, vital information on upcoming virtual events and webinars, ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... 2017 Entscheidung fällt ... Die internationale humanitäre Stadt soll um knapp ... Seine Hoheit Scheich Muhammad bin ... Herrscher von Dubai , hat den ... (International Humanitarian City IHC) zu verdreifachen, um den Betrieb ...
(Date:1/19/2017)... 19, 2017 The Global Therapy Partnering Terms ... to partnering deals and agreements entered into by the ... deals - Top deals by value - Deals listed ... type The report provides understanding and access to ... world,s leading healthcare companies. The report provides an ...
(Date:1/19/2017)... 19, 2017 Many patients don,t realize that ... when a pharmacy just a few blocks away charges ... this problem Medicationdiscountcard.com has created a price ... how much their medication will cost at most nearby ... Medicationdiscountcard.com takes all of ...
Breaking Medicine Technology: