Navigation Links
Blood Pressure Drug Does Not Help Those With Atrial Fibrillation

By Steven Reinberg
HealthDay Reporter

WEDNESDAY, March 9 (HealthDay News) -- The blood pressure-lowering drug Avapro doesn't seem to prevent heart disease and stroke in patients suffering from the irregular heartbeat called atrial fibrillation, a new Canadian study finds.

People with atrial fibrillation are at risk for heart disease and stroke, and lowering blood pressure is one way of staving off these potential problems. Avapro (irbesartan) is an angiotensin-receptor blocker, which lowers blood pressure by helping blood vessels dilate.

"Atrial fibrillation affects between 2 and 6 million men and women in the United States," said Dr. Gregg Fonarow, a spokesman for the American Heart Association and a professor of cardiology at the University of California, Los Angeles.

"Individuals with atrial fibrillation have substantially increased risk for stroke, other cardiovascular events, hospitalizations, and health-care expenditures," he added.

It has been "widely speculated" that angiotensin-receptor blockers might reduce the likelihood of recurrent atrial fibrillation and reduce the risk of cardiovascular events, Fonarow explained.

Earlier studies have suggested that angiotensin-receptor blockers benefit patients with atrial fibrillation, he added.

The latest report is published in the March 10 issue of the New England Journal of Medicine.

For the study, Dr. Salim Yusuf, from McMaster University in Hamilton, and colleagues randomly assigned 9,016 patients with atrial fibrillation to daily doses of Avapro or a placebo. Over about four years of follow-up, the researchers looked for incidents of stroke, heart attack, death and heart failure.

The researchers found that even though people taking Avapro had lower blood pressure than those taking placebo, people in both groups suffered a stroke, heart attack or died at the same rate over the four years.

In addition, those taking Avapro or placebo suffered heart failure at about the same rate, but those taking Avapro had a lower rate of hospitalization for heart failure, the researchers said. Also, there was no benefit from the drug among patients with a normal heart rhythm at the start of the study when it came to preventing hospitalization for atrial fibrillation.

The researchers also found more patients taking Avapro had blood pressure that was too low and more had kidney failure than did those receiving a placebo.

"This study demonstrates Avapro, despite a modest reduction in blood pressure, does not prevent recurrent episodes of atrial fibrillation or prevent cardiovascular events overall," Fonarow said. "There were no differences in heart attacks, cardiovascular deaths or deaths from any cause. There were modestly lower rates of hospitalization for heart failure and any cardiovascular hospitalization."

When this new trial is considered together with an earlier trial, it's evident that this class of blood pressure drugs has no effect in preventing episodes of atrial fibrillation in patients with intermittent atrial fibrillation, he added.

"In the absence of other indications, routine use of angiotensin-receptor blockers in patients with atrial fibrillation does not appear to be warranted," Fonarow said.

More information

For more on atrial fibrillation, visit the American Heart Association.

SOURCES: Gregg Fonarow, M.D., spokesman, American Heart Association, and professor, cardiology, University of California, Los Angeles; March 10, 2011, New England Journal of Medicine

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Redefining normal blood pressure
2. University of South Florida researchers find blood-brain barrier damaged by disease
3. Transplanting umbilical cord and menstrual blood-derived stem cells offer hope for disorders
4. OHSU physician explores method to reduce blood-clot risk in trauma patients
5. University of Nevada, Reno, teams with IMMY to make new life-saving blood test
6. Tight Blood Sugar Control May Put Some Diabetics at Risk
7. Napping May Help Keep Blood Pressure in Check
8. Blood Pressure Drugs May Help Heart Patients Without Hypertension
9. Dramatic Drop in Blood Infections Among ICU Patients: CDC
10. A small subset of normal white blood cells gives rise to a rare leukemia, study shows
11. Simple blood test at discharge could help reduce hospital readmissions for heart failure patients
Post Your Comments:
Related Image:
Blood Pressure Drug Does Not Help Those With Atrial Fibrillation 
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda Cheng, an ... Dr. Cheng has extensive experience with all areas of orthodontics, including robotic Suresmile ... orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced ... as its e-clinical software solution of choice.  This ... best possible value to their clients by offering ... The preferred relationship establishes nowEDC as the EDC ... for MedSource,s full-service clients.  "nowEDC has long been ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 Roche ... received 510(k) clearance for its Elecsys BRAHMS PCT (procalcitonin) ... severe sepsis or septic shock. With this clearance, Roche ... provide a fully integrated solution for sepsis risk assessment ... associated with bacterial infection and PCT levels in blood ...
(Date:6/23/2016)... Calif. , June 23, 2016 ... CST on Thursday, July 7, 2016 , , , , ... ) , , , , EXPERT PANELISTS:  , , ... Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar ... The global pharmaceutical industry is witnessing an exceptional ...
Breaking Medicine Technology: