Navigation Links
Blood Cell Genes May Signal Heart Disease
Date:10/8/2008

Small study finds their levels correlate with cardiovascular trouble

WEDNESDAY, Oct. 8 (HealthDay News) -- A test that measures the activity of genes in white blood cells might someday help doctors determine the proper treatment when someone complains of chest pain, researchers report.

The finding is interesting in part because of where it appears -- the first issue of a new American Heart Association journal, Circulation: Cardiovascular Genetics.

The journal, which will appear every two months, is needed "because the completion of the Human Genome Project has meant a rapid acceleration of our knowledge of what genes do, and how they are related to various diseases," said Dr. Ramachandran S. Vasan, a professor of medicine at Boston University School of Medicine who is the journal's editor.

"We have found a set of genes in white blood cells whose level of expression correlates with obstructive coronary artery disease," said Steven Rosenberg, chief scientific officer of CardioDx, a California biotechnology company.

Those genes were identified in a study of 41 people undergoing catheterization, a procedure used to determine whether chest pains are caused by blockage of a heart artery. "The set of genes we were looking at were upregulated in the presence of obstructive coronary artery disease," Rosenberg said.

The goal is a blood test looking at activity of those genes that can help determine whether someone complaining of chest pain needs an artery-opening procedure, he said.

"We hope that the test we develop can distinguish people who are at very low risk from those who need intervention," Rosenberg added.

A multi-center trial of the test is underway, with results expected by next year, he said. "We're hoping to build on these results," he said. "We want to show that a signal in the expression of genes in peripheral blood cells tells of what's going on in the arteries."

"What is really exciting is that the expression of these genes is also related to the degree of stenosis, or blockage of the arteries," study author Dr. William E. Kraus, a member of the Duke University Heart Center, said in a news release from the university. "This means that a blood test based on these genes could tell us not only if someone has coronary artery disease but also how bad the blockage in their arteries really is."

Another report in the same issue of the journal described an association between a specific genetic location and the risk of abdominal aortic aneurysm, the abnormal ballooning and weakening of an artery in the abdomen.

"We're not trying to find a genetic test for aneurysm," said study author Dr. Matthew Bown, a lecturer in surgery at the University of Leicester in England. "We're trying to find out what is the cause of aneurysm, so we can find a better treatment."

In the study, the gene was found in 53 percent of 899 people with aneurysms and 47 percent of those without the condition, so "if you have the gene, it doesn't mean much for you as an individual," Bown said. "But genes close to this marker may be related to what causes aneurysm."

More information

Some questions about the genetics of heart disease are answered by Brigham and Women's Hospital.



SOURCES: Ramachandran S. Vasan, M.D., professor, medicine, Boston University School of Medicine; Steven Rosenberg, Ph.D, chief scientific officer, CardioDx, Palo Alto, Calif.; Matthew Bown, M.D., lecturer, surgery, University of Leicester, England; October 2008 Circulation: Cardiovascular Genetics


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Specific antagonism lowers blood pressure
2. Restricting Blood Flow May Help Heart Bypass Patients
3. FDA Updates Prescription Guidelines for Blood Thinner
4. Doctors Often Miss High Blood Pressure in Kids
5. Back to School Means Return of School Blood Drives
6. Blood-flow detector software show promise in preventing brain damage
7. FDA Approves New Roche West Nile Virus Blood Screening Test
8. Australian-led international study shows blood pressure drugs cut death rate in type 2 diabetes
9. Laser blasts viruses in blood
10. Study Demonstrates Marteks Algal DHA Oil Improves Blood Triglyceride Lipid Levels
11. LifeMasters Provides Tips for Maintaining a Healthy Blood Cholesterol Level
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blood Cell Genes May Signal Heart Disease
(Date:6/27/2016)... ... 27, 2016 , ... A revolution is underway. Brooklyn-based ... experience for the millions of people who require these medical transport services annually. ... through the use of technology. Now, SmartEMS has put forth an industry-changing app ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... PawPaws ... a new product that was developed to enhance the health of felines. The formula ... , The two main herbs in the PawPaws Cat Kidney Support Supplement ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... -- Bracket , a leading clinical trial technology and ... platform, Bracket eCOA (SM) 6.0, at the 52 nd ... 2016 in Philadelphia , Pennsylvania.  A demonstration ... of its kind to fully integrate with RTSM, will be ... is a flexible platform for electronic clinical outcomes assessments that ...
Breaking Medicine Technology: