Navigation Links
Blood Cancer Drug Shows Promise Against Lupus

Experiments with mice found Velcade reduced dangerous autoantibodies

SUNDAY, June 8 (HealthDay News) -- A drug used to treat multiple myeloma, a cancer of the white blood cells, may also be a treatment for the chronic autoimmune disease lupus, German researchers report.

The drug, Velcade (bortezomib), which is a proteasome inhibitor, worked against the disease and prolonged survival in mice with lupus. The finding could one day offer treatment options for other antibody-associated diseases, too, the researchers said.

"Autoantibody-mediated diseases such as autoimmune hemolytic anemia, immune thrombocytopenia, myasthenia gravis and systemic lupus erythematosus are often difficult to treat," said lead researcher Dr. Reinhard Voll, of the University of Erlangen-Nuremberg.

A big problem is that plasma cells, which are the predominant producers of the disease-causing autoantibodies, can't be efficiently attacked with current treatments, Voll said.

Lupus is a so-called autoimmune disease in which the immune system attacks healthy cells and tissues by mistake, leading to damage to joints, skin, blood vessels and organs. There are many kinds of lupus, with the most common type being systemic lupus erythematosus, which affects many parts of the body. There's no one test to diagnose lupus, and it may take months or years to make the diagnosis. There's also no cure, but medicines and lifestyle changes can help control the disease, according to the U.S. National Institutes of Health

For the new study, Voll's team found that bortezomib efficiently eliminated the plasma cells in the mice, leading to a drastic decrease in autoantibodies and prolonged survival. And, the drug had no effect on other cells, he said.

"Proteasome inhibitors may be beneficial in refractory human diseases caused predominantly by autoantibodies," Voll said. "Proteasome inhibitors can selectively deplete plasma cells, which are resistant to current treatments."

Outside experts were divided on the findings, published in the June 8 online edition of Nature Medicine.

"This is a very exciting study that explores a novel mechanism for treating lupus erythematosus," said Dr. Jennifer Grossman, an assistant professor of medicine at the University of California, Los Angeles.

"The fact that antibodies almost completely disappeared is encouraging. I look forward to hearing more about this treatment in the future," she said.

But, another expert expressed concern that the treatment could adversely affect other cells in the human body.

"I think they're onto something important, it looks as if it has a remarkable therapeutic effect," said Dr. Noel Rose, director of the Autoimmune Disease Research Center at Johns Hopkins University. "The downside is that this is a proteasome inhibitor, and there is no reason to think that it would be specific for plasma cells. It does affect other rapidly proliferating cells."

Rose noted that many drugs may appear safe during an initial trial. "I'm still really suspicious that if this is used clinically, there are going to be side effects like effects on intestinal or other rapidly dividing cells," he said. "The question is, are the side effects going to be severe enough to prevent the use of this drug?"

More information

To learn more about lupus, the U.S. National Library of Medicine.

SOURCES: Reinhard Voll, M.D., University of Erlangen-Nuremberg, Erlangen, Germany; Jennifer Grossman, M.D., assistant professor of medicine, University of California, Los Angeles; Noel Rose, M.D., director, Autoimmune Disease Research Center, Johns Hopkins University, Baltimore; June 8, 2008, Nature Medicine, online

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Having heart surgery? Watch your blood sugar, especially if youre overweight or older
2. Scientists ID Gene Regulating Blood Glucose Levels
3. Studies Differ on Benefits of Aggressive Blood Sugar Control
4. MultiVu Video Feed: Study in the New England Journal of Medicine Shows High Blood Pressure Drug Tekturna(R) Reduces Key Marker of Kidney Disease
5. Can SonicMood Help to Significantly Lower High Blood Pressure? The Latest Research Answers With a Resounding YES!
6. New Yorks Catholic Archdiocese Hosting June 2 Blood Drive
7. Brisk Walking Lowers Blood Pressure, Increases Fitness in Obese
8. Special supplement on self-monitoring of blood glucose in diabetes technology & therapeutics
9. Self-Monitoring of Blood Glucose Highly Effective in Diabetes Care, According to a Special Issue of Diabetes Technology and Therapeutics
10. No association found between vitamin D concentration in blood and risk of prostate cancer
11. International Research Organization Responds to Recent Studies Purporting to Show That Transfusion of Older Red Blood Cells Leads to Greater Risk
Post Your Comments:
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD and Cambridge Memorial ... in the Waterloo region. Using the Ocean Platform, family physicians can now order ... electronic medical record (EMR) without the need for redundant patient entry or an ...
(Date:11/26/2015)... ... , ... The Catalent Applied Drug Delivery Institute today announced ... form selection in early phase drug development. The first of these is to ... the UK’s emerging life sciences companies, corporate partners, and investors, at Milton Park, ...
(Date:11/26/2015)... ... 26, 2015 , ... PRMA Plastic Surgery is updating their record books yet ... 6,000th free flap breast reconstruction surgery! , “What an accomplishment for the PRMA team, ... lives and it’s an honor to have served all of these women.” , PRMA ...
(Date:11/26/2015)... Viejo, CA (PRWEB) , ... November 26, 2015 ... ... users a new set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This ... style options. These classically-influenced trailer titles work with any font, giving users limitless ...
(Date:11/26/2015)... ... November 26, 2015 , ... Indosoft Inc., developer and distributor of ... server to improve system efficiency and reliability. , The new Q-Suite 6 platform is ... the system avoids locking itself into a specific piece of software for many key ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
(Date:11/25/2015)... 25, 2015 ... the "Global Brain Monitoring Devices Market ... --> ) has announced the ... Devices Market 2015-2019" report to their ... ( ) has announced the addition ...
(Date:11/25/2015)... N.C. , Nov. 25, 2015 ... the planned investment of at least $15.8  Million ... Wilmington, NC . The expansion ... capacity to meet the growing demands of the ... site expansion will provide up to ...
Breaking Medicine Technology: