Navigation Links
Blocking toxic effects could make clot-buster safer
Date:1/23/2009

ATLANTA--Since the introduction of the life-saving clot-busting drug tPA more than a decade ago, evidence has been accumulating that tPA (tissue-type plasminogen activator) can be a double-edged sword for a brain affected by stroke. Although it remains the only FDA-approved treatment for acute stroke, tPA can also contribute to inflammation and brain cell damage.

Scientists at Emory University School of Medicine are testing strategies for blocking LRP1, a molecule that appears to transmit inflammation signals triggered by tPA. They have found that in mice, genetically removing LRP1 from certain brain cells called microglia softens tPA's impact on the brain.

The results, published online this week by the American Journal of Pathology, suggest that blocking tPA's toxic effects could make it safer and allow doctors to use it more often on patients experiencing a stroke.

"tPA is a protein released naturally by the body in response to a blood clot," says Manuel Yepes, MD, PhD, assistant professor of neurology at Emory University School of Medicine. "But it's clearly not just lysing the clot."

Doctors in community hospitals can often be reluctant to administer tPA to patients who appear to be having a stroke, Yepes says. One reason is that tPA has been shown to increase the risk of bleeding in the brain, he says.

Researchers have shown that tPA treatment increases the permeability of the blood-brain barrier, and that it can cross from the blood vessels into the brain tissue, generating inflammation. tPA targets cells called microglia, which are similar to white blood cells of the immune system, although they live in the brain.

"Our strategy was to show that by blocking LRP1, you can prevent the inflammatory response to tPA," Yepes says. "This can be done either genetically, by deleting LRP1, or perhaps pharmacologically."

Yepes and his colleagues are now testing a natural inhibitor of LRP1 called
'/>"/>

Contact: Jennifer Johnson
jrjohn9@emory.edu
404-727-5696
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stopping ovarian cancer by blocking proteins coded by notorious gene
2. Blocking Oncogene Can Stop Spread of Ovarian Cancer
3. Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer
4. Pennsylvania Medical Society and AARP Criticize Senator Specter for Blocking Bill to Protect Access to Doctors and Improve Medicare
5. Blocking signaling protein prevents prostate cancer spread, Jefferson scientists find
6. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
7. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
8. Blocking Potent Oxidant Could Prevent Morphine Tolerance
9. Pre-emptive treatment helped curtail skin toxicity with panitumumab
10. DrScore.com Identifies Toxic Combination
11. Amira Announces the Successful Completion of GLP Toxicity Studies for a Novel DP2 Antagonist.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... AGA Medical Corporation announced,today that it received European ... (ACP). The ACP provides an innovative, minimally,invasive solution for ... intended use will be for the non-surgical occlusion of ... "The ACP is an important addition to the ...
... Scientists at UT Southwestern Medical Center have determined that the ... immune system how to fight off repeated infections of the ... Dec. 15 issue of the Journal of Immunology , ... and anti-viral therapies. , Typically, when a person is ...
... helped,explain how our brains build meaningful images from the bits ... Louisville Grawemeyer Award for Psychology. , Anne ... Princeton University , was selected for the ninth Grawemeyer,psychology ... Treisman, a cognitive psychologist, proposed in 1980 that ...
... immigrants in Oslo. Compared with Norwegians, the differences are also ... diseases. This is shown in a new report from the ... groups were compared with each other and the ethnic Norwegian ... care better. , The five immigrant groups in this ...
... The statistics for sexual assault are unsettling; the Department ... will be the victim of attempted or actual sexual ... researchers from two universities, including the University of Missouri, ... drug-facilitated sexual assault and fail to recognize the risk ...
... Center ranks No. 1 nationwide for the speed with which heart ... Cardiovascular Data Registry (NCDR). , ... (Vocus) December 2, ... speed with which heart attack patients are treated using balloon angioplasty, ...
Cached Medicine News:Health News:AGA Medical Receives European CE Mark Approval for AMPLATZER(R) Cardiac Plug 2Health News:Interferon needed for cells to 'remember' how to defeat a virus, UT Southwestern researchers report 2Health News:Theory of How Brain Builds Images Earns Grawemeyer Prize 2Health News:Large health differences between population groups in Norway 2Health News:Large health differences between population groups in Norway 3Health News:Large health differences between population groups in Norway 4Health News:MU researcher calls for increase in sexual assault awareness programs on college campuses 2Health News:MU researcher calls for increase in sexual assault awareness programs on college campuses 3Health News:UCSF Medical Center Leads Nation in ER Heart Attack Care 2Health News:UCSF Medical Center Leads Nation in ER Heart Attack Care 3
(Date:12/22/2014)... LAWRENCE, Mass. , Dec. 22, 2014 /PRNewswire/ ... a leading manufacturer of innovative dialysis products, announced ... (FDA) has cleared its System One™ to perform ... sleeping, known as home nocturnal hemodialysis. NxStage,s® System ... cleared by the FDA for this indication. ...
(Date:12/22/2014)... 22, 2014   TRU-D SmartUVC LLC, producers ... robot, announced today that the General Services Administration has ... 2019.   This newly formed agreement will ... of government purchasers, including Department of Veteran Affairs and ... Security contacts purchasing solutions for the Ebola effort in ...
(Date:12/22/2014)... , Dec. 22, 2014 Cyberonics, Inc. (NASDAQ: ... the treatment and management of epilepsy, today announced it will ... Conference on Wednesday, January 14, 2015, in San ... President and Chief Executive Officer, will speak at 11:00 AM ... be accessed by clicking on the Investor Relations link on ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... , ADDISON, Texas, Dec. 3 ... announced today that McKesson Medical-Surgical, Inc., one of ... approved ULURU Inc. to be one of its suppliers ... McKesson Medical-Surgical delivers a comprehensive offering of medical-surgical supplies, ...
... Dec. 3 Pioneer Surgical Technology, Inc., a surgeon-driven ... the Cervical Spine Care category at the 2009 Spine ... in conjunction with the North American Spine Society annual ... were the NuNec® Cervical Total Disc replacement (CTDR) device ...
Cached Medicine Technology:ULURU Inc. Obtains Status of Approved Supplier With McKesson. 2Pioneer(R) Surgical Technology, Inc. Receives Prestigious Spine Technology Awards 2
... Dehydroepiandrosterone (DHEA) is produced in the adrenal ... gonads [1,2,3]. DHEA serves as a precursor ... relatively weak androgenic activity, estimated at ~10% ... peripubertal children and in adult women, DHEA ...
... testosterone exists as unbound or free testosterone. ... SHBG with high affinity [1], while the ... the albumin-bound and free fractions may be ... action. Measurement of the free or unbound ...
... primary active hormone synthesized within the follicular ... is synthesized via a series of steps ... cells, (ii) iodination of tyrosine residues in ... 3-monoiodotyrosine and 3,5-diiodotyrosine (MIT and DIT), and ...
... protein-3 (IGFBP-3) is the main binding protein for ... component of the ~150 kDa ternary complex. This ... or IGF-II and ALS, allowing IGFBP-3, along with ... The molar concentration of IGFBP-3 in normal serum ...
Medicine Products: