Navigation Links
Blocking toxic effects could make clot-buster safer
Date:1/23/2009

ATLANTA--Since the introduction of the life-saving clot-busting drug tPA more than a decade ago, evidence has been accumulating that tPA (tissue-type plasminogen activator) can be a double-edged sword for a brain affected by stroke. Although it remains the only FDA-approved treatment for acute stroke, tPA can also contribute to inflammation and brain cell damage.

Scientists at Emory University School of Medicine are testing strategies for blocking LRP1, a molecule that appears to transmit inflammation signals triggered by tPA. They have found that in mice, genetically removing LRP1 from certain brain cells called microglia softens tPA's impact on the brain.

The results, published online this week by the American Journal of Pathology, suggest that blocking tPA's toxic effects could make it safer and allow doctors to use it more often on patients experiencing a stroke.

"tPA is a protein released naturally by the body in response to a blood clot," says Manuel Yepes, MD, PhD, assistant professor of neurology at Emory University School of Medicine. "But it's clearly not just lysing the clot."

Doctors in community hospitals can often be reluctant to administer tPA to patients who appear to be having a stroke, Yepes says. One reason is that tPA has been shown to increase the risk of bleeding in the brain, he says.

Researchers have shown that tPA treatment increases the permeability of the blood-brain barrier, and that it can cross from the blood vessels into the brain tissue, generating inflammation. tPA targets cells called microglia, which are similar to white blood cells of the immune system, although they live in the brain.

"Our strategy was to show that by blocking LRP1, you can prevent the inflammatory response to tPA," Yepes says. "This can be done either genetically, by deleting LRP1, or perhaps pharmacologically."

Yepes and his colleagues are now testing a natural inhibitor of LRP1 called
'/>"/>

Contact: Jennifer Johnson
jrjohn9@emory.edu
404-727-5696
Emory University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stopping ovarian cancer by blocking proteins coded by notorious gene
2. Blocking Oncogene Can Stop Spread of Ovarian Cancer
3. Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer
4. Pennsylvania Medical Society and AARP Criticize Senator Specter for Blocking Bill to Protect Access to Doctors and Improve Medicare
5. Blocking signaling protein prevents prostate cancer spread, Jefferson scientists find
6. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
7. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
8. Blocking Potent Oxidant Could Prevent Morphine Tolerance
9. Pre-emptive treatment helped curtail skin toxicity with panitumumab
10. DrScore.com Identifies Toxic Combination
11. Amira Announces the Successful Completion of GLP Toxicity Studies for a Novel DP2 Antagonist.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... 01, 2015 , ... Lume Wellness creators Alex, Robert, and Sam have announced ... Apple AppStore. , The app is designed to track various metrics of wellness, ... to view personal health and use this information for positive behavior modification. Lume Wellness ...
(Date:8/1/2015)... ... ... Phil Valentine – the Executive Director of Connecticut Community for Addiction Recovery (CCAR) – began ... and heading north. Since that day, Phil has hiked over 1400 miles in nine states. ... family. He visited CCAR and left an inspirational message to his staff: “You can ...
(Date:7/31/2015)... ... July 31, 2015 , ... When the weather turned hot and warm-season ... type of sod called Leisure Time(TM) zoysia . It's nicknamed LTZ(TM) for short. ... introduction of this new type of sod, Super-Sod is giving away red Adirondack chairs ...
(Date:7/31/2015)... ... July 31, 2015 , ... Ticket Down is a reliable source ... in Chicago at Grant Park. The festival will end on Sunday, August 2nd. ... Chicago for the annual Lollapalooza. This unique and unbelievably popular festival attracts the ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... run by GoodThreads. The store can be accessed by visiting http://www.curemeso.org/store . ... which are customizable. The best part: whenever a product is purchased, the Meso ...
Breaking Medicine News(10 mins):Health News:Lume Wellness Launches Health and Fitness Tracker iPhone App 2Health News:Connecticut Executive Hikes Appalachian Trail to Raise Awareness About Recovery. 2Health News:Super-Sod Introduces Leisure Time(TM) Zoysia Grass with an Adirondack Chair Promotion 2Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3
... Brian Bosma to serve as Master of Ceremonies, ... will,converge in Indianapolis once again for the annual Talk*Walk*Run ... a.m. -- 1:00 p.m. at Fort Harrison,State Park at ... State Representative Brian Bosma will officiate as Master of,Ceremonies. ...
... timely treatment for heart attack because they expect the warning ... tightening in the chest, shortness of breath, clutching the chest ... researchers who presented their study at the American Heart Associations ... (QCOR) in Cardiovascular Disease and Stroke. , Researchers studied ...
... in the Community: Parkview Christian Center Outreach Ministry ... ... Babers and the Parkview,Christian Center are excited to announce the planned September ... Haines City and surrounding areas., The new Outreach Ministry building, located ...
... Screenings And Education about ... Skin Cancer Prevention, SKILLMAN, ... of The Skin Cancer Foundation,s "Road,to Healthy Skin Tour." The tour ... dermatologists, in a private,room inside a 38-foot customized RV. The tour ...
... a Social Business Enterprise, Facility Can Potentially Grow ... Annually, DHAKA, Bangladesh, May 2 The ... 50,000 eye examinations and,10,000 cataract operations annually, will ... Muhammad Yunus and the Hon,ble Adviser, Incharge,of Ministry ...
... and unpaid health care for full-time workers and their ... $45 billion a year, according to a report from ... in the cost of public coverage such as Medicaid ... billion in uncompensated care expenseswhich are paid by Federal, ...
Cached Medicine News:Health News:Hear Indiana Announces Talk*Walk*Run 2008 2Health News:Hear Indiana Announces Talk*Walk*Run 2008 3Health News:Some women more likely to miss or ignore heart attack warning signs 2Health News:Some women more likely to miss or ignore heart attack warning signs 3Health News:Parkview Christian Center Announces September 2008 Opening of Outreach Ministry Building 2Health News:AVEENO(R) Announces Sponsorship and Kick-Off of The Skin Cancer Foundation's 'Road to Healthy Skin Tour' Presented by AVEENO(R) and Rite Aid 2Health News:AVEENO(R) Announces Sponsorship and Kick-Off of The Skin Cancer Foundation's 'Road to Healthy Skin Tour' Presented by AVEENO(R) and Rite Aid 3Health News:Professor Muhammad Yunus and The Green Children to Open First Grameen Eye Hospital in Bangladesh on May 12, 2008 2Health News:Professor Muhammad Yunus and The Green Children to Open First Grameen Eye Hospital in Bangladesh on May 12, 2008 3Health News:$45 billion a year is spent by public on health costs for full-time workers and families 2Health News:$45 billion a year is spent by public on health costs for full-time workers and families 3Health News:$45 billion a year is spent by public on health costs for full-time workers and families 4
(Date:7/31/2015)... 2015 Egalet Corporation (Nasdaq: EGLT ... focused on developing, manufacturing and marketing innovative pain ... announced underwritten public offering of 7,666,667 shares of ... of $11.25 per share. The shares of common ... upon the exercise in full by the underwriters ...
(Date:7/31/2015)... 31, 2015 Magnaquest, a ... data and cloud computing operators has signed a ... giant for Internet of Things (IoT) related initiative. ... on subscription model.      (Logo: ... striving for business innovations to make healthcare services ...
(Date:7/30/2015)... July 30, 2015  ResMed Inc. (NYSE: RMD ... 30, 2015.  Revenue for the quarter was $453.1 million, ... June 30, 2014 (a 17 percent increase on a ... with the quarter ended June 30, 2014.  Diluted earnings ... the quarter ended June 30, 2014.  ...
Breaking Medicine Technology:Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 2Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 3Egalet Announces Closing of Public Offering of Common Stock and Exercise in Full of Underwriters' Option to Purchase Additional Shares 4Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: