Navigation Links
Blocking telomerase kills cancer cells but provokes resistance, progression
Date:2/21/2012

hese cross-species copy number alterations included several known tumor-suppressing genes and oncogenes, suggesting that initial telomere dysfunction not only drives primary tumor development but also confers malignant traits such as invasiveness.

Telomerase extinction works - at first

The team then took tumor cells from late-generation mice with activated telomerase - the aggressive tumors - and passaged them four times through groups of mice treated with either 4-OHT to trigger telomerase production or the control vehicle that leaves the enzyme off.

During the first two rounds, survival for the two groups was about the same. In the third round, the control mice had a major improvement in survival over the telomerase arm, indicating that telomere erosion had allowed cellular defense mechanisms to pick off genomically unstable cells.

However, in the fourth passage, survival of the control-treated mice fell back toward that of mice with active telomerase. The tumors had become resistant without relying on telomerase.

Alternative lengthening of telomeres rescues cancer cells

An analysis showed that telomere lengths of tumor cells with active telomerase remained largely unchanged across the four passages. Telomeres shortened in cells lacking telomerase through the first two passages followed by a sharp increase during the third and fourth passages.

Other molecular evidence pointed to alternative lengthening of telomeres in telomerase-absent cells.

They found that ALT-positive tumors had different gene expression patterns - 891 genes with increased expression, 1,345 with decreased - compared to telomerase-positive tumors.

Key gene in mitochondrial pathway active in ALT cells

Many genes were found in networks regulating mitochondrial biology and oxidative stress regulation. PGC-1 was the only gene in both pathways with increased expression and copy number gain in
'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. PET scans confirm effectiveness of estrogen-blocking drugs in breast cancer patients
2. Blocking molecular target could make more cancers treatable with PARP inhibitors
3. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
4. UIC researcher unveils new approach to blocking malaria transmission
5. Adiponectin shows potential in blocking obesity-related carcinogenesis
6. Blocking an oncogene in liver cancer could be potential therapy option
7. Can blocking a frown keep bad feelings at bay?
8. Blocking DNA repair protein could lead to targeted, safer cancer therapy
9. Blocking Protein May Stem COPD
10. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
11. New 3-D model of RNA core domain of enzyme telomerase may offer clues to cancer, aging
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014 For Dr. Iris Hunter, a job ... an extension of her life’s mission. Her extensive experience in ... owner of FirstLight HomeCare, make it clear that Hunter’s mission ... that my work makes a difference in the lives of ... so after much research, I felt ready to start on ...
(Date:10/22/2014)... Los Angeles, California (PRWEB) October 22, 2014 ... Recovery 2.0: Move Beyond Addiction and Upgrade Your Life (Paperback; ... the field of Yoga & Recovery. This book is ... and thrive in a life of recovery. , Recovery ... of the 12 Steps; Recovery 2.0 is a guide for ...
(Date:10/22/2014)... Losing Weight Your Body’s Way , In ... in the face, it certainly can be difficult to choose ... an extra favor by doing it the healthy way? Set ... listen to your body, exercise regularly, and choose foods with ... losing weight; you need to exercise more and eat less. ...
(Date:10/22/2014)... By Steven Reinberg ... -- Infants who quickly add weight and length may be ... study suggests. In adults, certain genes have been linked ... promote proportionate gains in fat and lean muscle, the researchers ... be heavier and taller. By ages 2 and 3, however, ...
(Date:10/22/2014)... Oct. 21, 2014 (HealthDay News) -- Measures taken by ... in Ebola-ravaged Liberia may have limited the spread of ... report. The Firestone Natural Rubber Co. provides health ... residents of nearby densely populated communities. Between Aug. ... suspected Ebola cases among those 80,000 people. That incidence ...
Breaking Medicine News(10 mins):Health News:Dr. Iris Hunter to Host Grand Opening of FirstLight HomeCare Tomorrow 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2Health News:Tall, Heavy 1-Year-Olds May Be at Risk for Obesity Later, Study Finds 2Health News:Tire Company Sets Standard for Ebola Care in Liberia: CDC 2
... how the risk of death and heart attack can be ... that doubling the usual dose of an anti-clotting drug before ... in which a balloon-tipped catheter is threaded into an artery. ... and unblock the vessel. A small synthetic tube - stent ...
... has been found out that there is no association between ... -- and breast cancer. More than 43,000 women were studied ... had their average daily intake of acrylamide monitored. No evidence ... whose intake was higher was documented. Acrylamide was first discovered ...
... In the 83rd General Session of the International Association ... have presented the results of a study// that says ... bad breath. ,Oral bad odor or so called ... compounds like hydrogen sulfide. The study revealed that volunteers ...
... A new study has found out that depression has to ... anti-depressants // used to treat the same. The study was ... ,At first glance, results showed both the newer and older ... attack within the first month of being prescribed.The older class ...
... drug tezosentan did not improve worsening heart failure or prevent ... hopes. The above fact was found out in the largest ... was conducted to evaluate if something more could be done ... hospital discharge and prevent them from coming back. ,More ...
... help in controlling obesity. A new study coming up in ... that dietary calcium present in the yogurt has got anti-obesity ... and decrease in lipogenesis. ,The study took ... put on balanced deficit diets and the other was put ...
Cached Medicine News:
(Date:10/22/2014)... Oct 22, 2014 Antigen Discovery Inc. (ADi), ... , announced the receipt of a National Institutes ... (SBIR) from the National Institute of Dental and Craniofacial Research ... of a Pan-HIV Protein Microarray Chip, which will contain ... subtypes and aid in the development of safe and ...
(Date:10/22/2014)... BASKING RIDGE, N.J. , Oct. 22, 2014 ... (RMANJ), a world-renowned leader in the field ... more rapid approach to embryonic screening. The research ... American Society for Reproductive Medicine (ASRM) meeting in ... chromosome screening (CCS) and single gene defect (SGD) ...
(Date:10/22/2014)... , Oct. 22, 2014  Paper Pak Industries, ... developed APLS ® Body Guard Bio, a ... spread of bacteria and virus while protecting service ... Guard Bio features a rugged, external nylon shell, ... create a leak-proof inner chamber that contains contaminated ...
Breaking Medicine Technology:Biomarker Discovery Company, Antigen Discovery Inc., Awarded an NIH Phase I Small Business Innovation Research Grant to Develop a Pan-HIV Protein Microarray Chip 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 2New IVF Research Highlights Improved Genetic Screening Approach To Help Parents Have Healthier Babies 3New, State-Of-The-Art Body Bag Minimizes The Spread Of Bacteria And Virus 2
... FRANCISCO, Oct. 26 ClinOps, LLC, a customer ... Connie Andrews has joined the company as Senior ... with her more than 28 years of clinical ... disease, gastrointestinal diseases, cardiovascular, central nervous system, oncology, ...
... Reportlinker.com announces that a new market research ... Reportlinker Adds Ion Channel ... , http://www.reportlinker.com/p0156556/Reportlinker-Adds-Ion-Channel-Modulator-Pipelines-Targets-and-Agents-in-Development.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=prnewswire ... significant opportunity to address an underexploited class ...
Cached Medicine Technology:ClinOps, LLC Enhances Senior Management Team With Addition of Connie Andrews as Senior Vice President of Clinical Operations 2Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development 2Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development 3Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development 4Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development 5Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development 6Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development 7
... ClozeX Wound Closures represent a ... and healing of surgical incisions, ... transparent, coaptive film design provides ... speed, control, visibility and cosmetic ...
... These powdered surgical gloves were designed ... Plus delivers comfort, barrier protection, and value. ... for both wet and dry hands. The ... fit, while the micro-rough surface offers sensitivity ...
... can enjoy the comfort ... the most technically advanced ... on the market. Ansells ... the needed barrier protection ...
... Now you can ... tactile sensitivity of the ... Free surgical gloves on ... Free gloves provide the ...
Medicine Products: