Navigation Links
Blocking signaling protein prevents prostate cancer spread, Jefferson scientists find

(PHILADELPHIA) Researchers at the Kimmel Cancer Center at Jefferson in Philadelphia have shown that by blocking a signaling protein, they can prevent prostate cancer cells from metastatic dissemination. The work opens the door to future studies examining the protein as a target for therapies aimed at keeping prostate cancer at bay.

In a series of experiments in both the laboratory and animal models, Marja Nevalainen, M.D., Ph.D., associate professor of Cancer Biology at Jefferson Medical College of Thomas Jefferson University and her co-workers found that the protein, Stat3, is key to the metastatic progression of prostate cancer. Dr. Nevalainen's group reports its findings in the June 2008 issue of the American Journal of Pathology.

According to Dr. Nevalainen, previous studies have shown that Stat3 is very active in metastatic prostate cancer, and the protein has been linked to cancer metastasis in several different cancer types. Because metastatic prostate cancer lacks effective therapies, understanding the molecular changes involved is critical.

To clarify Stat3's role in prostate cancer progression, she and her co-workers performed several studies. In one case, the scientists used an antibody for Stat3, for example, to show that it is activated in 77 percent of lymph nodes and 66 percent of bone metastases in human prostate cancer. In another experiment, the scientists prompted mouse prostate cancer cells to overproduce the normal Stat3 protein by delivering it through a virus vehicle. They saw a dramatic increase in prostate cancer metastases compared to controls.

Specifically, in mice lacking a working immune system, they showed that Stat3 caused a 33-fold increase in metastases.

"This is the first proof that Stat3 may have a major effect on metastatic dissemination of prostate cancer," Dr. Nevalainen says. "Stat3 now becomes a potential drug target to interfere with the metastatic progression of prostate cancer."

While her team's results "open up other opportunities to study the mechanism of prostate cancer metastases," Dr. Nevalainen notes that Stat3 might have possible use in the prevention of primary prostate cancer from progressing to metastatic disease as well.

She suggests that studies testing newly developed Stat3 inhibitors in prostate cancer should include testing their effectiveness in blocking prostate cancer metastases in experimental animal models.


Contact: Steve Benowitz
Thomas Jefferson University

Related medicine news :

1. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
2. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
3. Blocking Potent Oxidant Could Prevent Morphine Tolerance
4. Secrets of cellular signaling shed light on new cancer stem cell therapies
5. Researchers learn how signaling molecule orchestrates breast cancers spread
6. Model offers new understanding of cell signaling
7. Signaling protein helps limit damage in heart attack, Jefferson scientists show
8. St. Jude finds signaling system that halts the growth of a childhood brain cancer
9. Scientists shed light on long-distance signaling in developing neurons
10. Cooper Clinic at Craig Ranch Opens Signaling the Next Phase of CooperLife Health-Focused Residential Community in McKinney
11. Emory researchers identify signaling protein for multiple myeloma
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... ... through sharing, the 2016 Building Better Radiology Marketing Programs meeting will ... on Sunday, March 6, 2016, at Caesars Palace in Las Vegas with a ...
(Date:11/27/2015)... ... 2015 , ... Keeping in mind challenges faced by parents ... consultation, has collaborated with a leading web-based marketplace for extra-curricular activities for children ... and bring advice from parenting experts within their reach. As a part of ...
(Date:11/27/2015)... ... November 27, 2015 , ... Avid collector, Andrew Hawley from Vintage Rock Posters, ... posters. This is one of Joplin's most famous and beautiful concert posters. The concert ... Michigan in Ann Arbor. The According to Hawley, "It is hard to believe that ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... real-time eReferral system for diagnostic imaging in the Waterloo region. Using the Ocean ... Nuclear Medicine tests directly from their electronic medical record (EMR) without the need ...
(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is updating ... our surgeons performed their 6,000th free flap breast reconstruction surgery! , “What an accomplishment ... day excited to rebuild lives and it’s an honor to have served all of ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... has announced the addition of the  ... in the European Therapeutic Drug Monitoring ... Forecasts, Competitive Intelligence, Emerging Opportunities"  report ... ) has announced the addition ...
(Date:11/26/2015)... DUBLIN , November 26, 2015 ... of the "Self Administration of High Viscosity ... ) has announced the addition of ... report to their offering. --> ... the addition of the "Self Administration of ...
(Date:11/26/2015)... November 26, 2015 ... the "Radioimmunoassay Market by Type (Reagents ... Industry, Academics, Clinical Diagnostic Labs), Application (Research, ... to 2020" report to their offering. ... the addition of the "Radioimmunoassay Market ...
Breaking Medicine Technology: