Navigation Links
Blocking molecular target could make more cancers treatable with PARP inhibitors
Date:6/29/2011

BOSTON--Researchers at Dana-Farber Cancer Institute have demonstrated a molecular strategy they say could make a much larger variety of tumors treatable with PARP inhibitors, a promising new class of cancer drugs.

Currently, the role of PARP inhibitors has mainly been restricted to cancers whose cells lack functioning versions of the damage-repair proteins BRCA1 or BRCA2 -- chiefly certain breast and ovarian cancers.

In a paper published online by Nature Medicine, Geoffrey Shapiro, MD, and colleagues report that the BRCA1 repair protein is dependent on another protein, CDK1, known primarily as a regulator of the cell division cycle. When the scientists blocked CDK1 in cancer cell lines and in a mouse model of lung cancer, BRCA1 function was disrupted, making them susceptible to being killed by a PARP inhibitor.

Because most types of tumors don't have a mutated BRCA1 protein, they are less likely to be affected by PARP inhibitor treatment. The new findings, said Shapiro, "suggest that by blocking CDK1, we can disable BRCA1 in many types of cancers and make them sensitive to a PARP inhibitor. It could extend the use of these drugs to a much larger group of patients."

Shapiro, who heads Dana-Farber's Early Drug Development Center, said a clinical trial combining a CDK1 blocker and a PARP inhibitor in a variety of solid tumors is being planned.

Cells are equipped to heal damage to their DNA strands, which are constantly being nicked or broken by exposure to environmental contaminants or randomly during cell division. Cancer cells, in addition, become adept at repairing potentially lethal DNA damage caused by radiation and chemotherapy drugs, and use their DNA repair machinery to survive and grow uncontrollably.

A major thrust in cancer research currently is developing ways to disable tumor cells' repair toolkits to make them more vulnerable to DNA-damaging agents. PARP inhibitor drugs prevent tumor cells from
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
2. UIC researcher unveils new approach to blocking malaria transmission
3. Adiponectin shows potential in blocking obesity-related carcinogenesis
4. Blocking an oncogene in liver cancer could be potential therapy option
5. Can blocking a frown keep bad feelings at bay?
6. Blocking DNA repair protein could lead to targeted, safer cancer therapy
7. Blocking Protein May Stem COPD
8. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
9. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
10. Molecular glue sticks it to cancer
11. Molecular movements could lead to new way to treat cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blocking molecular target could make more cancers treatable with PARP inhibitors
(Date:7/30/2015)... ... July 30, 2015 , ... In a meaningful ritual ... Serenity Palms Drug Addiction Treatment Center have created an addiction graveyard. Sharing this with ... its most beloved residents, Rocky Hudson . Hudson (1945-2015) fell in love with ...
(Date:7/30/2015)... , ... July 30, 2015 , ... ... program at ATA’s 21st Annual Meeting and Tradeshow focused exclusively on telemedicine, telehealth ... 300 cutting-edge health care technology vendors, will take place May 14-17, 2016 in ...
(Date:7/30/2015)... ... ... " DevExpress ” was featured on NewsWatch as part ... large businesses making an impact in their industry. Susan Bridges, a reporter for ... how DevExpress has provided software development tools that have helped app developers build ...
(Date:7/30/2015)... ... July 30, 2015 , ... ... announce its position as one of Medicare’s top-rated care centers. The video ... the CMS rating system, which monitors health inspections, staffing, and quality measures. ...
(Date:7/30/2015)... ... July 30, 2015 , ... OncLive®’s extensive roster ... Jonsson Comprehensive Cancer Center (JCCC) mutually agreed to collaborate on projects that ... and marketing groups will help spread the news about the center’s leading-edge cancer ...
Breaking Medicine News(10 mins):Health News:Serenity Palms Honors Rocky Hudson, an Advocate of AA and a Beloved Resident of Palm Springs 2Health News:Serenity Palms Honors Rocky Hudson, an Advocate of AA and a Beloved Resident of Palm Springs 3Health News:Presentation Proposals for ATA 2016 are Now Being Accepted Online at ATA2016.com 2Health News:Presentation Proposals for ATA 2016 are Now Being Accepted Online at ATA2016.com 3Health News:Software to Develop High-Performance Data-Driven Apps was Featured on NewsWatch Television 2Health News:Beachside Nursing Center Releases New Video 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 2Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 3Health News:UCLA Jonsson Comprehensive Cancer Center Teams with OncLive® as a Strategic Alliance Partner 4
... ANN ARBOR, Mich. Having an egg allergy is ... vaccination. According to new recommendations by the American ... a history of suspected egg allergy should first be ... and diagnosis but can probably receive the vaccination. Matthew ...
... News) -- Very young children are extraordinarily trusting of what ... the contrary, finds a new study. In what may ... found that 3-year-olds placed more trust in information they are ... this study, an adult showed children a red and a ...
... Cancer Institute has awarded a $4.37 million grant to ... Center, to advance a recent scientific laboratory discovery into ... issued under the American Recovery and Reinvestment Act, will ... identified by Toretsky and his team a critical ...
... Texas, October 18, 2010 Estimates of the prevalence ... States population has non‐alcoholic fatty liver disease (NAFLD). NAFLD ... function tests in the United States, a trend related ... (NASH), the progressive form of NAFLD, can lead to ...
... Research exploring the progression of colon polyps to ... was among the clinical science presented at the 75th ... in San Antonio today. The Progression to Colorectal ... colon known as sessile serrated adenomas (SSA) are found ...
... are reimbursed by Medicaid for administering influenza shots may ... the conclusion of a study published online today in ... by a team of researchers at the University of ... three flu seasons and contends that the number of ...
Cached Medicine News:Health News:Egg allergy: Not a reason to avoid flu vaccine after all 2Health News:Egg allergy: Not a reason to avoid flu vaccine after all 3Health News:Young Kids Easily Trust What They're Told: Study 2Health News:$4.37 million NCI grant accelerates recent laboratory finding in Ewing's sarcoma 2Health News:$4.37 million NCI grant accelerates recent laboratory finding in Ewing's sarcoma 3Health News:Encouraging findings suggest new avenues for treating liver disease in overweight Americans 2Health News:Encouraging findings suggest new avenues for treating liver disease in overweight Americans 3Health News:Colonoscopy technique increases polyp detection in far reaches of right colon 2Health News:Medicaid reimbursement and childhood flu vaccination rates linked 2Health News:Medicaid reimbursement and childhood flu vaccination rates linked 3
(Date:7/30/2015)... SAN DIEGO , July 30, 2015  Arena ... will host a conference call and webcast at 5:00 ... August 5, 2015, to discuss second quarter 2015 financial ... its financial results after the NASDAQ Global Select Market ... be accessed by dialing 877.643.7155 for domestic callers and ...
(Date:7/30/2015)... EnteroMedics Inc. (NASDAQ: ETRM ), the ... obesity, metabolic diseases and other gastrointestinal disorders, today announced ... August 6, 2015, at 11:00 AM Eastern Time to ... 30, 2015, and to provide an update on the ... the Maestro® System. Conference Call Details ...
(Date:7/30/2015)... VANCOUVER, Washington , July 30, 2015 ... diagnostics market 2015 research reports analyzing tumor ... well as providing forecasts for the global ... The Global Cancer Diagnostics Industry (Tumor Biomarker ... spread across 207 pages, talking about 9 ...
Breaking Medicine Technology:Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 2Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 3Arena Pharmaceuticals to Host Second Quarter 2015 Financial Results and Corporate Update Conference Call and Webcast on Wednesday, August 5 4EnteroMedics to Host Second Quarter 2015 Financial Results and Company Update Conference Call 2EnteroMedics to Host Second Quarter 2015 Financial Results and Company Update Conference Call 3Cancer Diagnostics Market to see 12% CAGR to 2020: Analysis of Tumor Biomarker Tests, Imaging, Endoscopy, Biopsy and More in New Research Reports 2Cancer Diagnostics Market to see 12% CAGR to 2020: Analysis of Tumor Biomarker Tests, Imaging, Endoscopy, Biopsy and More in New Research Reports 3Cancer Diagnostics Market to see 12% CAGR to 2020: Analysis of Tumor Biomarker Tests, Imaging, Endoscopy, Biopsy and More in New Research Reports 4Cancer Diagnostics Market to see 12% CAGR to 2020: Analysis of Tumor Biomarker Tests, Imaging, Endoscopy, Biopsy and More in New Research Reports 5Cancer Diagnostics Market to see 12% CAGR to 2020: Analysis of Tumor Biomarker Tests, Imaging, Endoscopy, Biopsy and More in New Research Reports 6
...  MedAssurant, Inc., a leading provider of data-driven ... IPA (HCPIPA), one of the largest physician-owned ... has selected MedAssurant,s Prospective Advantage® and Capitated ... gaps in care and quality to improve ...
... knowing how to take a child,s temperature the correct way ... accuracy of results can be a guessing game.  The new ... Behind Ear Thermometer ... confidence to parents and peace of mind.  Using patented technology, ...
Cached Medicine Technology:Healthcare Partners, IPA, Implements MedAssurant's Innovative, Data-Driven Solutions 2Healthcare Partners, IPA, Implements MedAssurant's Innovative, Data-Driven Solutions 3Behind The Ear -- A New Site To Measure for Fever 2Behind The Ear -- A New Site To Measure for Fever 3
... up to 10 inches/ 25 cm thinner than other ... Allegra X-22 Series is the space-saving multipurpose solution for ... / 46 cm wide • 11 Rotor Library • ... ways to Spin 1.5 mL & PCR+ Tubes: ...
... is up to 10 inches/ 25 cm thinner than ... the Allegra X-22 Series is the space-saving multipurpose solution ... inches / 46 cm wide • 11 Rotor Library ... different ways to Spin 1.5 mL & PCR+ Tubes: ...
... centrifuges offer high-volume versatility along with a ... them ideal for a wide variety of ... Four- or six-place sealed swinging bucket rotor, ... offered , Lare capacity (4 x 750 ...
... Multipurpose high performance centrifuge designed to accommodate ... devices is refrigerated for heat labile samples. ... include refrigerated capability with automatic quick cooling ... < 7 min, no maintenance brushless motor, ...
Medicine Products: