Navigation Links
Blocking molecular target could make more cancers treatable with PARP inhibitors
Date:6/29/2011

BOSTON--Researchers at Dana-Farber Cancer Institute have demonstrated a molecular strategy they say could make a much larger variety of tumors treatable with PARP inhibitors, a promising new class of cancer drugs.

Currently, the role of PARP inhibitors has mainly been restricted to cancers whose cells lack functioning versions of the damage-repair proteins BRCA1 or BRCA2 -- chiefly certain breast and ovarian cancers.

In a paper published online by Nature Medicine, Geoffrey Shapiro, MD, and colleagues report that the BRCA1 repair protein is dependent on another protein, CDK1, known primarily as a regulator of the cell division cycle. When the scientists blocked CDK1 in cancer cell lines and in a mouse model of lung cancer, BRCA1 function was disrupted, making them susceptible to being killed by a PARP inhibitor.

Because most types of tumors don't have a mutated BRCA1 protein, they are less likely to be affected by PARP inhibitor treatment. The new findings, said Shapiro, "suggest that by blocking CDK1, we can disable BRCA1 in many types of cancers and make them sensitive to a PARP inhibitor. It could extend the use of these drugs to a much larger group of patients."

Shapiro, who heads Dana-Farber's Early Drug Development Center, said a clinical trial combining a CDK1 blocker and a PARP inhibitor in a variety of solid tumors is being planned.

Cells are equipped to heal damage to their DNA strands, which are constantly being nicked or broken by exposure to environmental contaminants or randomly during cell division. Cancer cells, in addition, become adept at repairing potentially lethal DNA damage caused by radiation and chemotherapy drugs, and use their DNA repair machinery to survive and grow uncontrollably.

A major thrust in cancer research currently is developing ways to disable tumor cells' repair toolkits to make them more vulnerable to DNA-damaging agents. PARP inhibitor drugs prevent tumor cells from
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
2. UIC researcher unveils new approach to blocking malaria transmission
3. Adiponectin shows potential in blocking obesity-related carcinogenesis
4. Blocking an oncogene in liver cancer could be potential therapy option
5. Can blocking a frown keep bad feelings at bay?
6. Blocking DNA repair protein could lead to targeted, safer cancer therapy
7. Blocking Protein May Stem COPD
8. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
9. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
10. Molecular glue sticks it to cancer
11. Molecular movements could lead to new way to treat cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blocking molecular target could make more cancers treatable with PARP inhibitors
(Date:9/2/2014)... 2014 Recently, Top 10 Best ... and announced that JustHost ( http://www.justhost.com/track/seohosts ) and ... , “The hosting suppliers we recommend are the ... on hosting features, uptime and server speed with ... SEO Hosting says. “We believe that BlueHost and ...
(Date:9/2/2014)... DC (PRWEB) September 02, 2014 TCG, a ... by Inc. 5000 as one of the fastest-growing companies in ... eighth time total. TCG was previously recognized in 2013, 2012, ... , TCG’s revenue has grown 86% from 2010 to 2013, ... the fastest growing businesses in America - up 635 spots ...
(Date:9/2/2014)... Cloud Medical Doctor Software Corporation (Cloud-MDs) ... Practice Business Operations solutions and Billing Services for the ... solutions for all industries announced today that its CEO ... of the CME in Chicago by PRICE Futures Group ... are very proud of the recognition that our CipherLoc ...
(Date:9/2/2014)... (PRWEB) September 02, 2014 The Wm. Jennings ... fair and public town hall meeting for Veterans and their ... at the outreach fair to provide Veterans with valuable healthcare ... “The town hall will provide a forum where we can ... programs.” , The outreach fair will be held 4:45 p.m. ...
(Date:9/2/2014)... News) -- Complications are rare among breast cancer ... study indicates. However, the researchers did find ... slightly higher risk for certain complications than a ... 18,000 breast cancer patients who had a single ... reconstruction and were followed for 30 days after ...
Breaking Medicine News(10 mins):Health News:TCG One of the Fastest-Growing Companies in America – for the Eighth Time! 2Health News:Cloud Medical Doctor Software Corporation's CEO Interviewed by the Price Futures Group 2Health News:Cloud Medical Doctor Software Corporation's CEO Interviewed by the Price Futures Group 3Health News:Complication Rates Low With Mastectomy, Breast Reconstruction: Study 2
... of some on the market , WEDNESDAY, Oct. 14 (HealthDay ... House Office of Management and Budget, is reported to drink ... genetic test to see if his body could metabolize his ... body is perfectly suited to the task, and Orszag can ...
... emerged from 47,000 votes on over 700 essay entries as ... essay contest. The essay contest awards each winner $1,000 ... make life easier for those affected by breast cancer. , ... memory to taking a supportive child to Disney World to ...
... ... hold employment to persevere in this difficult job market. Profiles International suggests that employees ... , ... October 14, 2009 -- Profiles International, a developer of employee assessments and ...
... ... in Class Alzheimer,s Care , ... Neenah, Wisc. (Vocus) October 14, 2009 -- Tracy Hoffman, M.D., one of the nation,s premier ... innovator with 16 facilities in Wisconsin and Illinois. , , , , ,As Corporate Director ...
... ... sleeping problems report better sleep with Gene-Eden, a natural supplement that targets many common chronic ... Rochester, NY (PRWEB) ... natural antiviral Gene-Eden. Analysis of the interviews revealed that the users of the supplement experience ...
... ... Management,(School for Managers) to be held at Sheraton, Wakefield, MA, , ... Boston, MA (PRWEB) October 14, 2009 ... training program, ,Strategic Problem Solving & Advanced Time Management, to be held Wednesday, November ...
Cached Medicine News:Health News:Are Commercial Genetic Tests Worth Taking? 2Health News:Are Commercial Genetic Tests Worth Taking? 3Health News:Fifteen Women Win National O-Cedar(R) Essay Contest 2Health News:As Unemployment Continues to Rise, Profiles International Encourages Employers and Employees to Focus on Value 2Health News:As Unemployment Continues to Rise, Profiles International Encourages Employers and Employees to Focus on Value 3Health News:Renowned Geriatrician Tracy Hoffman Tapped as Corporate Director of Memory Care Excellence By Fast-Growing CRL 2Health News:Renowned Geriatrician Tracy Hoffman Tapped as Corporate Director of Memory Care Excellence By Fast-Growing CRL 3Health News:Users of Gene-Eden, a Natural Antiviral, Report less Sleeping Problems in a Recent Study 2Health News:Users of Gene-Eden, a Natural Antiviral, Report less Sleeping Problems in a Recent Study 3Health News:One Day Management Training Program to be Offered November 18 in Boston Area 2Health News:One Day Management Training Program to be Offered November 18 in Boston Area 3Health News:One Day Management Training Program to be Offered November 18 in Boston Area 4Health News:One Day Management Training Program to be Offered November 18 in Boston Area 5
(Date:9/2/2014)... , Sept. 2, 2014 /PRNewswire-iReach/ -- The ... by universal healthcare coverage and good access to ... population and its associated disease burden, well-defined regulatory ... introduction of a new manufacturing policy will drive ... However, a focus on generic substitution and price ...
(Date:9/2/2014)... , Sept. 2, 2014  Cyberonics, Inc. ... from the ANTHEM-HF clinical study.  Results of the ... during a major European cardiology congress and concurrently ... show Autonomic Regulation Therapy (ART) in patients ... impaired heart function is safe, improves the heart,s ...
(Date:9/2/2014)... , Sept. 2, 2014  Based on ... treatment device market, Frost & Sullivan recognizes Novian ... & Sullivan Award for Technology Innovation Leadership. Novian ... fibroadenoma and malignant tumors with its proprietary technology, ... is a reliable, accurate, and easy-to-control ultrasound-guided thermo ...
Breaking Medicine Technology:Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 2Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 3Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 4Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 5ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 2ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 3ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 4ANTHEM-HF Shows Autonomic Regulation Therapy Is Safe And Improves Heart Function In Patients With Chronic Heart Failure 5Novian Health Wins Acclaim from Frost & Sullivan for Novilase Interstitial Laser Ablation Therapy for Early-Stage Malignant Breast Tumors 2Novian Health Wins Acclaim from Frost & Sullivan for Novilase Interstitial Laser Ablation Therapy for Early-Stage Malignant Breast Tumors 3Novian Health Wins Acclaim from Frost & Sullivan for Novilase Interstitial Laser Ablation Therapy for Early-Stage Malignant Breast Tumors 4Novian Health Wins Acclaim from Frost & Sullivan for Novilase Interstitial Laser Ablation Therapy for Early-Stage Malignant Breast Tumors 5
... , CINCINNATI , June 21 ... to its HARMONIC® line of surgical devices, the HARMONIC ... designed to extend the reach of surgeons for minimally ... (or 9cm) than the standard length HARMONIC ACE® device. ...
... today announced that six-month clinical follow-up data show the safety and ... (Sequent Please®, B.Braun) followed by implantation of the company,s Genous Bio-engineered ... , , ... single center, all-comers POTENT ( P aclitaxel-eluting ball O on and ...
Cached Medicine Technology:Ethicon Endo-Surgery Introduces HARMONIC ACE® 45 cm Curved Shears at ASMBS 2Ethicon Endo-Surgery Introduces HARMONIC ACE® 45 cm Curved Shears at ASMBS 3Data Show OrbusNeich's Genous™ Bio-engineered R stent™ is Safe and Effective in Combination with Drug-Eluting Balloon 2Data Show OrbusNeich's Genous™ Bio-engineered R stent™ is Safe and Effective in Combination with Drug-Eluting Balloon 3
Female Compression VEST w/sleeves...
Male Support Brief...
Ideal for lower abdominal procedures. Comes with a left side separating zipper....
Arm Compression Garment...
Medicine Products: