Navigation Links
Blocking molecular target could make more cancers treatable with PARP inhibitors
Date:6/29/2011

BOSTON--Researchers at Dana-Farber Cancer Institute have demonstrated a molecular strategy they say could make a much larger variety of tumors treatable with PARP inhibitors, a promising new class of cancer drugs.

Currently, the role of PARP inhibitors has mainly been restricted to cancers whose cells lack functioning versions of the damage-repair proteins BRCA1 or BRCA2 -- chiefly certain breast and ovarian cancers.

In a paper published online by Nature Medicine, Geoffrey Shapiro, MD, and colleagues report that the BRCA1 repair protein is dependent on another protein, CDK1, known primarily as a regulator of the cell division cycle. When the scientists blocked CDK1 in cancer cell lines and in a mouse model of lung cancer, BRCA1 function was disrupted, making them susceptible to being killed by a PARP inhibitor.

Because most types of tumors don't have a mutated BRCA1 protein, they are less likely to be affected by PARP inhibitor treatment. The new findings, said Shapiro, "suggest that by blocking CDK1, we can disable BRCA1 in many types of cancers and make them sensitive to a PARP inhibitor. It could extend the use of these drugs to a much larger group of patients."

Shapiro, who heads Dana-Farber's Early Drug Development Center, said a clinical trial combining a CDK1 blocker and a PARP inhibitor in a variety of solid tumors is being planned.

Cells are equipped to heal damage to their DNA strands, which are constantly being nicked or broken by exposure to environmental contaminants or randomly during cell division. Cancer cells, in addition, become adept at repairing potentially lethal DNA damage caused by radiation and chemotherapy drugs, and use their DNA repair machinery to survive and grow uncontrollably.

A major thrust in cancer research currently is developing ways to disable tumor cells' repair toolkits to make them more vulnerable to DNA-damaging agents. PARP inhibitor drugs prevent tumor cells from
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. New study finds compounds show promise in blocking STAT3 signaling as treatment for osteosarcoma
2. UIC researcher unveils new approach to blocking malaria transmission
3. Adiponectin shows potential in blocking obesity-related carcinogenesis
4. Blocking an oncogene in liver cancer could be potential therapy option
5. Can blocking a frown keep bad feelings at bay?
6. Blocking DNA repair protein could lead to targeted, safer cancer therapy
7. Blocking Protein May Stem COPD
8. Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed
9. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
10. Molecular glue sticks it to cancer
11. Molecular movements could lead to new way to treat cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blocking molecular target could make more cancers treatable with PARP inhibitors
(Date:4/17/2014)... One of the most popular vaccine brands for ... doctors may be overlooking some cost factors when choosing ... more expensive option, according to a new study by ... to administer can be driven by numerous factors," says ... a professor of computer science and of mathematics at ...
(Date:4/17/2014)... School of Medicine report that older women, plucky individuals ... are more likely to be compassionate toward strangers than ... this month,s issue of the International Journal of ... with better health and well-being as we age, the ... outcomes of individuals whose deficits in compassion put them ...
(Date:4/17/2014)... Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, was ... April issue of Nature Reviews Microbiology , ... Dr. McCullers, a world-renowned infectious disease specialist, and ... University of Tennessee Health Science Center, analyzed the ... 1957 and 1968 pandemics, as well as more ...
(Date:4/17/2014)... (April 17, 2014) Doctors who treat patients ... lymphangioleiomyomatosis (LAM) can face an agonizing treatment decision. ... the disease and help relieve shortness of breath. ... and sirolimus can cause potentially fatal complications following ... Dr. Daniel Dilling, medical director of Loyola University ...
(Date:4/17/2014)... affects about one in five infants in the United ... the first several months after birth. Research into probiotic ... however, the April 1, 2014 issue of the ... a study, "Probiotics and Infant Colic," concluding that the ... infant colic did not reduce crying or fussing ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:The ilk of human kindness 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
... the first time scientists have been able to film, ... and a DNA strand from an attacking virus. Researchers ... Scanning Atomic Force Microscope in Japan to produce amazing ... a virus trying to infect a bacterial host. ...
... commonly used measure for pain screening may only be modestly ... Medicine and the University of North Carolina. In a study ... General Internal Medicine, they evaluate the usefulness of a scale ... pain from 0 (no pain) to 10 (worst pain). ...
... next generation in medication therapy management ... and medication adherence ... a leading,developer of innovative clinical solutions that facilitate pharmacist-based,patient ... of the MirixaPro(TM) product suite (MirixaPro 2.2). With this,latest ...
... of the 62nd United Nations General Assembly Tomorrow, September ... ... dying,of hunger every day and governments failing to meet their millennium,commitment to halve ... and hunger to play a,central role "on the table" of the 62nd United ...
... often a key factor in the decision , MONDAY, Sept. ... deciding factor for men and women considering retirement, according to ... depression are more likely to retire early, while retirement-age women ... mild. , According to researchers at the University of Pennsylvania, ...
... Contrary to concerns that restricting work hours for surgical ... the residents education, a study in the September issue ... found that limiting work hours does not compromise education ... found that the new model improved overall teaching effectiveness ...
Cached Medicine News:Health News:Scientists reveal DNA-enzyme interaction with first ever real time footage 2Health News:Rating your pain from 0 to 10 might not help your doctor 2Health News:Mirixa Debuts New Clinical Technology Solutions for Enhancing Patient Care 2Health News:HungerFREE Campaign Tells UN: 'Put food on the table' 2Health News:Depression Pushes Middle-Aged Workers to Retire 2Health News:Study finds limiting work hours for surgical residents enhances training 2
(Date:1/15/2014)... , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com adds "China ... store . (Photo: http://photos.prnewswire.com/prnh/20140115/MN46792 ) ... and policy support, China,s orthopedic ... with total market size rising from 3.28 billion yuan ...
(Date:1/15/2014)... Jan. 15, 2014  Novation, the leading health care supply ... IT value-added reseller (VAR) national contracts that expand its ... services at lower costs. These include manufacturer product and ... initiative assistance and ongoing IT consulting support. ...
(Date:1/15/2014)... NEW YORK , January 15, 2014 ... BreedIT Ltd., the exclusive worldwide distributor of highly sophisticated ... that on January 7, 2014, the Company,s board of ... Ben-Zion Weiner as its new member of the ...
Breaking Medicine Technology:Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... NEW YORK, Dec. 27, 2011 Reportlinker.com ... is available in its catalogue: ... Respiratory Devices Market Outlook to 2017- Respiratory ... Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, ...
... 27, 2011 ReportsnReports adds new ... Latin America , to its store. This report ... terms of their attractiveness as pharmaceutical markets and ... and pricing are examined. The report presents results ...
Cached Medicine Technology:South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 2South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 3South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 4South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 5South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 6South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 7South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 8South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 9South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 10South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 11South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 12South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 13South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 14South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 15South and Central America Anesthesia and Respiratory Devices Market Outlook to 2017- Respiratory Devices, Respiratory Measurement Devices, Airway and Anesthesia Devices, Anesthesia Machines, Sleep Apnea Diagnostic Systems, Pain Management Devices an 16Latin America Emerging Pharmaceutical Markets - Argentina, Chile, Colombia, Peru, and Venezuela 2Latin America Emerging Pharmaceutical Markets - Argentina, Chile, Colombia, Peru, and Venezuela 3
The Natural Selection family of specialty allografts are spinal allograft devices to eliminate the need for painful autograft harvesting....
... are unique corticocancellous allografts comprised of ... unique Dovetail geometry permitting a precise ... Allografts are processed from donor vertebral ... Specially designed instruments facilitate the insertion ...
Lumbar Allograft with Osteoactive advantage. Promotes bone formation and faster incorporation. Derived from the proven technology behind Grafton DBM. Maintains structural integrity and strength....
... Titanium Microdiscectomy System offers strength and ... The boss anteater titanium microdiscectomy system ... discs provides for less invasive procedures ... is designed to provide low profile, ...
Medicine Products: