Navigation Links
Blocking molecular pathway with whimsical name possible therapeutic target for pancreatic cancer
Date:12/14/2008

A possible new therapeutic target for pancreatic cancer, the most lethal form of human cancer, has been identified in the proteins whose DNA recipe comes from gene, "Seven-In-Absentia," according to researchers at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.

In their studies with the fruit fly, Drosophila melanogaster, at the Mayo Clinic College of Medicine in Minnesota, scientists found a link between the "Seven-In-Absentia" or SINA gene and the aggressive cellular transformation, oncogenesis and metastasis that characterize pancreatic cancer.

Scientists already knew that a mutation in the K-RAS gene underlies the abnormal, excessive cell growth of pancreatic cancer.

Because the mutated form of this growth-promoting gene is hyperactivated, a major signaling pathway that drives cell growth is in over-drive in most patients with this cancer.

The "Seven-In-Absentia-Homolog" (SIAH) protein seems to work as a check and balance mechanism in the K-RAS pathway by chewing up and turning off the excessive growth-promoting proteins produced by the hyperactive, mutated form of the gene, says Amy Tang whose Mayo lab conducted the research.

"By attacking the SIAH-based protein degrading machinery, we block tumor formation in one of the most aggressive human cancers cells known," she reports.

Because of these results, SIAH may be an attractive new target for novel anti-RAS and anti-cancer therapy in pancreatic cancer, the median survival of which is only six months, and the mortality rate is 95 percent.

By inhibiting SIAH function, Tang and her colleagues were able to completely abolish both tumorigenesis and metastasis of human pancreatic cancer cells that were growing in "nude" mice that have immune system deficits that prevent them from rejecting foreign tissue.

"It is likely to move into the clinical setting for study as an interventiona
'/>"/>

Contact: Cathy Yarbrough
sciencematter@yahoo.com
858-243-1814
American Society for Cell Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Blocking Potent Oxidant Could Prevent Morphine Tolerance
2. Blocking protein kills prostate cancer cells, inhibits tumor growth, Jefferson scientists find
3. Blocking the effect of inflammation-causing cells lowered prostate cancer cells invasion
4. Blocking signaling protein prevents prostate cancer spread, Jefferson scientists find
5. Pennsylvania Medical Society and AARP Criticize Senator Specter for Blocking Bill to Protect Access to Doctors and Improve Medicare
6. A new molecular zip code, and a new drug target for Huntingtons disease
7. New knock-out gene model provides molecular clues to breast cancer
8. Molecular probe paints cancer cells in living animals, Stanford researchers find
9. Story ideas from molecular & cellular proteomics
10. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
11. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... August 21, 2014 Xarelto lawsuit ( ... patients to suffer uncontrollable internal bleeding and other serious ... LLP reports. According to court documents, a wrongful death ... Court, Easter District of New York by the family ... bleeding event that was allegedly caused by Xarelto. Among ...
(Date:8/21/2014)... NY (PRWEB) August 21, 2014 ... products manufactured by Boston Scientific has begun in ... first bellwether trial. The Rottenstein Law Group LLP, ... women with claims of harm stemming from the ... a claim for compensation for injuries suffered at ...
(Date:8/21/2014)... Revista, a one-stop source for healthcare ... is “on a roll.” Today, the Annapolis-based company ... Southeast, Mid-Atlantic and Midwest areas of the country ... available, comprehensive medical property database tracking these regions. ... including existing and recently added, is 34,549. This ...
(Date:8/21/2014)... 2014 (HealthDay News) -- In a new review of ... avoid eating tuna due to concerns about mercury exposure. ... second only to shrimp as the most commonly eaten ... to avoid all tuna," Jean Halloran, director of food ... Consumer Reports, said in a news release from the ...
(Date:8/21/2014)... August 21, 2014 Sasha is a 10 ... Sasha is getting a little older, and is having trouble ... Sasha just happens to have an owner who purchased a ... had an accident, and could no longer get up and ... her finished basement. She had tried a stair lift, ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 3Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 4Health News:Transvaginal Mesh Lawsuit News: Second Boston Scientific Mesh Bellwether Trial Begins, The Rottenstein Law Group LLP Reports 2Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 2Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 3Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 4Health News:Revista Medical Property Data Now Available for the Mid-Atlantic, Southeast and Midwest Regions 5Health News:Consumer Reports Advises Pregnant Women to Avoid Tuna 2Health News:Sasha Gets a Butler Mobility Inclined Platform Lift 2
... circulating blood and important in blood clotting, can promote ... into the brain, triggering inflammation that leads to MS-related ... Diego (UCSD) School of Medicine have identified a fibrin-derived ... models of MS, reducing MS symptoms. ,“Current ...
... A study by Drs Benjamin Kile and David Huang found ... This discovery is sure //to raise the hope of formulating ... platelets stored in blood banks. This will in turn increase ... ,An undesirable side effect of cancer chemotherapy ...
... found if given a choice of exercising alone, with ... age, most adults would rather exercise with others in ... provide useful insight into the preferences of older exercisers, ... initiatives [in communities around the world],” said lead researcher ...
... have come out with study results that encourage health care ... marked by the presence of tumor cells in ... may be a definite clue to chances of reccurence ... with risks of the cancer staging a comeback. ...
... wife Elizabeth Edwards has been diagnosed with// a recurrent case ... right rib bone and hence classified as metastatic or stage ... and underwent treatment, was cancer free for the last two ... conference in North Carolina that she had sought medical treatment ...
... study finds that improving the institutional culture (ethos) of ... on bad habits like// smoking, drinking, drug abuse and ... of Hygiene and Tropical Medicine's Centre for Research on ... teenage pregnancy are major public health challenges and argue ...
Cached Medicine News:Health News:Inhibiting Blood to Save the Brain 2Health News:Improved Platelet Life Span Increases Better Patient Care 2Health News:Exercising With Peers Has Added Appeal 2Health News:Doctors Warned to Keep Track of Tumorous Lymph Nodes 2Health News:Doctors Hopeful for Elizabeth Edwards 2Health News:Improve School Ethos to Combat Teen Evils 2
(Date:8/21/2014)... , Aug. 21, 2014 /PRNewswire-iReach/ -- ... Equipment, Inc. for the third straight year, No. ... 500|5000, an exclusive ranking of the nation,s fastest-growing ... look at the most important segment of the ... Timberland, Dell, Domino,s Pizza, LinkedIn, Zillow, and many ...
(Date:8/21/2014)... 21, 2014 BreedIT Corp., ... the exclusive worldwide license holder and distributor of ... and researchers, today is pleased to announce the ... Seach Ltd, a leading Israeli medical Cannabis breeder. ... develop new breeds of medical Cannabis to meet ...
(Date:8/21/2014)... FRANCISCO , Aug. 21, 2014 /PRNewswire/ ... Food and Drug Administration (FDA) has granted ... detect atrial fibrillation (AFib), the most common ... process (algorithm) instantly detects if patients are ... taken on the mobile phone based AliveCor® ...
Breaking Medicine Technology:Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4AliveCor Receives First FDA Clearance to Detect a Serious Heart Condition in an ECG on a Mobile Device 2
... King LT™ is a superior, disposable supraglottic ... advances in materials and design to provide ... LT™ emergency airway is a safe, reliable, ... emergency ventilation when direct laryngoscopy is not ...
All oral and nasal airways are manufactured with smooth, rounded edges for increased patient comfort and safety., ,Portex® offers a broad selection of airways for a variety of clinical applicati...
... Available in even sizes 20-36F. Single use. ... patient comfort. The Latex-Free Robertazzi is the ... offering the best solution for latex sensitivity. ... offer a quality latex-free product as your ...
Bag of 9 airways 20-36 French (1234) or 4 airways 12-18 French (1233). Includes four foil packages of lubricating jelly....
Medicine Products: