Navigation Links
Blocking Potent Oxidant Could Prevent Morphine Tolerance
Date:11/2/2007

Findings in animal tests may lead to new therapies for treating chronic pain

FRIDAY, Nov. 2 (HealthDay News) -- Blocking a substance called peroxynitrite, a potent oxidant that's formed when patients take morphine, can prevent the development of tolerance to the pain-relieving effects of the narcotic, according to animal tests conducted by Saint Louis University of Medicine researchers.

They said their findings, published in the November issue of the Journal of Clinical Investigation, could lead to new therapies that prevent morphine tolerance and the severe side effects caused by having to give patients escalating doses of the painkiller.

Morphine and other opiate narcotics are the most powerful treatments for acute and chronic pain. However, their pain-killing effectiveness decreases quickly and significantly with repeated doses.

In this study, researchers found that repeated doses of morphine caused peroxynitrite to develop in the spinal cord, resulting in inflammation and damage to proteins and DNA in that area. Putting the brakes on peroxynitrite -- either by causing it to decompose once it formed or by blocking it from forming in the first place -- prevented morphine tolerance.

"We believe these findings represent a major breakthrough in understanding how tolerance to the pain-relieving action of morphine and other opiate medications develops -- and how it can be prevented from happening in the first place," study author Daniela Salvemini, a professor of internal medicine in the division of pulmonary, critical care and sleep medicine, said in a prepared statement.

This research may help in the development of therapies that enable patients to take morphine without developing tolerance.

"For instance, when morphine is administered, another drug could be given simultaneously that prevents peroxynitrite from working and thus causing tolerance to develop," Salvemini explained.


'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Protein Fragments Blocking Cures Alzheimers Disease
2. Multiple Sclerosis Can Be Treated By Blocking Fat Hormone
3. Blocking Pain Found To Slow Down The Healing Process
4. HIV blocking protein in Monkey
5. Improving The Survival Of Lung Cancer Patients By Blocking The Effects Of Estrogen
6. Ventilation Systems Not Effective in Blocking Tobacco Smoke
7. Study Says - Blocking aP2 Protein Prevents Airway Diseases
8. Sunscreen Blocking UVA Radiation Receives Federal Approval
9. New Cancer-Blocking Algae Found
10. Blocking Glucocorticoid Prevents Stress-Induced Skin Abnormalities
11. Blocking Enzyme Can Treat Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... ... ... Difass USA, a modern supplement brand committed to excellence, understands that sometimes ... knowing that there is hopefully a vacation to look forward to this summer. But ... a vacation can be quite stressful, and it’s difficult sometimes to fully disconnect and ...
(Date:7/7/2015)... MA (PRWEB) , ... July 07, 2015 , ... The ... AIDS Action Committee of Massachusetts , and the Multicultural AIDS Coalition ... and other men who have sex with men (MSM) and transgender women, the ...
(Date:7/7/2015)... ... 2015 , ... SC&H Group, a leading audit, tax, and consulting firm, recently ... community through company-wide volunteering efforts. , On an annual basis, in coordination with ... in need throughout Baltimore and Washington D.C. , This year, SC&H Group’s ...
(Date:7/7/2015)... ... July 07, 2015 , ... ... the experience for its patient community using its IDF ePHR, an electronic personal ... primary immunodeficiency diseases (PI) to easily track their health information, including symptoms, diagnoses, ...
(Date:7/7/2015)... ... 07, 2015 , ... FSAstore.com today announced the launch of its ... makes it simple to use, spend and manage HSA funds with innovative tools including ... , According to a report by Devenir , approximately 13.8 million Americans have ...
Breaking Medicine News(10 mins):Health News:Difass USA Offers Eight Tips to Help Relax and Enjoy Summer Vacation 2Health News:Difass USA Offers Eight Tips to Help Relax and Enjoy Summer Vacation 3Health News:CDC Awards Fenway Health, AIDS Action, Multicultural AIDS Coalition $3.78m For ‘Getting To Zero’ HIV Prevention Partnership 2Health News:CDC Awards Fenway Health, AIDS Action, Multicultural AIDS Coalition $3.78m For ‘Getting To Zero’ HIV Prevention Partnership 3Health News:SC&H Group Celebrates 9th Annual Day of Service 2Health News:Get Real Health Launches New Mobile App for Immune Deficiency Foundation Patient Community 2Health News:Get Real Health Launches New Mobile App for Immune Deficiency Foundation Patient Community 3Health News:Introducing HSAstore.com: A New E-commerce Site for Health Savings Account Eligible Products and Services 2Health News:Introducing HSAstore.com: A New E-commerce Site for Health Savings Account Eligible Products and Services 3
... The Providence Service,Corporation (Nasdaq: PRSC ) today announced ... Convertible Senior Subordinated Notes due in,2014. RBC Capital ... The private placement was priced off today,s closing ... annum and are convertible into,Providence common shares at a ...
... -- Net loss narrows to $2.6 million - record performance,-- Domestic open-heart revenues of $6.7 million - ... 2006, ... over third quarter 2006 ... quarter ...
... premiums written increase 21% over the ... quarterly results., FARMINGTON, Conn., Nov. 6 Darwin Professional,Underwriters, Inc. ... financial results for the third quarter ended September 30,2007. Highlights include: ... million. Third quarter gross premiums written ...
... Businesses, LEHIGH VALLEY, Pa., Nov. 6 Air ... in advanced discussions over Wacker,s,purchase of Air Products, shareholdings ... Air Products Polymers (APP), including APP,s,vinyl acetate-ethylene activities. Air ... As for WPS, Wacker owns 80 percent and Air ...
... first annual HealthSaver,Caffeinated Cities Survey, commissioned by ... found that the most caffeinated city in ... Phoenix and Atlanta. (Photo: http://www.newscom.com/cgi-bin/prnh/20071106/NYTU175 ... are San Francisco/Oakland, followed,closely by Philadelphia, New ...
... Calif., Nov. 6 The scant,details of the health ... and Senate President pro Tem Don Perata provides some,potential ... would,guarantee a windfall for private health insurance companies out ... to the Foundation for,Taxpayer and Consumer Rights (FTCR)., ...
Cached Medicine News:Health News:Providence Service Corporation Completes Private Placement of $70 Million of Convertible Senior Subordinated Notes 2Health News:AtriCure Reports Third Quarter 2007 Financial Results 2Health News:AtriCure Reports Third Quarter 2007 Financial Results 3Health News:AtriCure Reports Third Quarter 2007 Financial Results 4Health News:AtriCure Reports Third Quarter 2007 Financial Results 5Health News:AtriCure Reports Third Quarter 2007 Financial Results 6Health News:AtriCure Reports Third Quarter 2007 Financial Results 7Health News:AtriCure Reports Third Quarter 2007 Financial Results 8Health News:AtriCure Reports Third Quarter 2007 Financial Results 9Health News:Darwin Professional Underwriters, Inc. Reports Record Net Income of $8.4 Million for the Third Quarter 2Health News:Darwin Professional Underwriters, Inc. Reports Record Net Income of $8.4 Million for the Third Quarter 3Health News:Darwin Professional Underwriters, Inc. Reports Record Net Income of $8.4 Million for the Third Quarter 4Health News:Darwin Professional Underwriters, Inc. Reports Record Net Income of $8.4 Million for the Third Quarter 5Health News:Darwin Professional Underwriters, Inc. Reports Record Net Income of $8.4 Million for the Third Quarter 6Health News:Darwin Professional Underwriters, Inc. Reports Record Net Income of $8.4 Million for the Third Quarter 7Health News:Air Products in Advanced Discussions With Wacker Over Polymers Business 2Health News:Caffeine Survey Reveals Most, Least Caffeinated Cities 2Health News:Caffeine Survey Reveals Most, Least Caffeinated Cities 3Health News:Caffeine Survey Reveals Most, Least Caffeinated Cities 4Health News:Caffeine Survey Reveals Most, Least Caffeinated Cities 5Health News:Caffeine Survey Reveals Most, Least Caffeinated Cities 6Health News:Caffeine Survey Reveals Most, Least Caffeinated Cities 7Health News:The Good, the Bad, and the Ugly of the Nunez/Perata Health Plan 2
(Date:7/7/2015)... Calif. , July 7, 2015  Essentialis, a venture-backed ... agonists for the treatment of orphan neurobehavioral and metabolic diseases, ... and CSO, will present a corporate update at the Cantor ... Conference Date: Wednesday, July 8, 2015 Time: ... About Essentialis, Inc. ...
(Date:7/7/2015)... NEW YORK , July 7, 2015 ... new generation of drugs within human and veterinary oncology, ... the Securities and Exchange Commission, in connection with the ... the NASDAQ Stock Market. The number of American Depositary ... price range for the offering have not yet been ...
(Date:7/7/2015)... Ill. , July 7, 2015  Monopar Therapeutics ... oncology compounds, announced that its co-founder and CEO, ... British Council,s Education U.K. Alumni Entrepreneurial Award. The British ... China , India , and ... recognizes outstanding achievements made by entrepreneurs who have leveraged ...
Breaking Medicine Technology:Oasmia Pharmaceutical Files a Registration Statement on Form F-1/A for its Proposed Public Offering and an Application with NASDAQ for a US Listing and Announces Investor Roadshow 2Monopar Therapeutics Announces Founder And CEO Chandler Robinson Awarded The British Council's Education U.K. Alumni Award 2Monopar Therapeutics Announces Founder And CEO Chandler Robinson Awarded The British Council's Education U.K. Alumni Award 3
... 2011 Scientists at Osel Inc . and ... a new way to prevent HIV infection by genetically ... block viral transmission. Bioengineered bacteria introduced into the vaginal ... of simian HIV (SHIV) by nearly two thirds. ...
... July 18, 2011 Data from high-risk patients requiring ... nondeferrable, non-cardiac surgery show good short- and long-term clinical ... according to a study published online on the journal ... In the single-center study, patients treated with the Genous ...
Cached Medicine Technology:Scientists Use Live Bacteria to Fight HIV 2Scientists Use Live Bacteria to Fight HIV 3OrbusNeich's Genous™ Stent Enables Early and Safe Discontinuation of Dual Antiplatelet Therapy in High-Risk Patients Requiring Nondeferrable, Non-Cardiac Surgery 2OrbusNeich's Genous™ Stent Enables Early and Safe Discontinuation of Dual Antiplatelet Therapy in High-Risk Patients Requiring Nondeferrable, Non-Cardiac Surgery 3
60 month warranty, constructed entirely of aluminum alloy, allows the selection of 11 units of measure....
Digital Thermometer & High-Low Temp Alarm, -50C to +90C...
... Independent controls for Digital ... stainless steel front. Anodized aluminum ends. ... stainless steel floor. , Oversized refrigeration ... 10C , Positive seal self-closing doors. ...
... F340 is a basic laboratory system for ... results can be obtained when used with ... electrode. • Fast and easy one and ... for five buffers (pH 1.68, 4.00, 7.00, ...
Medicine Products: