Navigation Links
Blocking Potent Oxidant Could Prevent Morphine Tolerance
Date:11/2/2007

Findings in animal tests may lead to new therapies for treating chronic pain

FRIDAY, Nov. 2 (HealthDay News) -- Blocking a substance called peroxynitrite, a potent oxidant that's formed when patients take morphine, can prevent the development of tolerance to the pain-relieving effects of the narcotic, according to animal tests conducted by Saint Louis University of Medicine researchers.

They said their findings, published in the November issue of the Journal of Clinical Investigation, could lead to new therapies that prevent morphine tolerance and the severe side effects caused by having to give patients escalating doses of the painkiller.

Morphine and other opiate narcotics are the most powerful treatments for acute and chronic pain. However, their pain-killing effectiveness decreases quickly and significantly with repeated doses.

In this study, researchers found that repeated doses of morphine caused peroxynitrite to develop in the spinal cord, resulting in inflammation and damage to proteins and DNA in that area. Putting the brakes on peroxynitrite -- either by causing it to decompose once it formed or by blocking it from forming in the first place -- prevented morphine tolerance.

"We believe these findings represent a major breakthrough in understanding how tolerance to the pain-relieving action of morphine and other opiate medications develops -- and how it can be prevented from happening in the first place," study author Daniela Salvemini, a professor of internal medicine in the division of pulmonary, critical care and sleep medicine, said in a prepared statement.

This research may help in the development of therapies that enable patients to take morphine without developing tolerance.

"For instance, when morphine is administered, another drug could be given simultaneously that prevents peroxynitrite from working and thus causing tolerance to develop," Salvemini explained.

More information

The American Academy of Family Physicians has more about chronic pain medications.



-- Robert Preidt



SOURCE: Saint Louis University, news release, Nov. 1, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Protein Fragments Blocking Cures Alzheimers Disease
2. Multiple Sclerosis Can Be Treated By Blocking Fat Hormone
3. Blocking Pain Found To Slow Down The Healing Process
4. HIV blocking protein in Monkey
5. Improving The Survival Of Lung Cancer Patients By Blocking The Effects Of Estrogen
6. Ventilation Systems Not Effective in Blocking Tobacco Smoke
7. Study Says - Blocking aP2 Protein Prevents Airway Diseases
8. Sunscreen Blocking UVA Radiation Receives Federal Approval
9. New Cancer-Blocking Algae Found
10. Blocking Glucocorticoid Prevents Stress-Induced Skin Abnormalities
11. Blocking Enzyme Can Treat Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... , ... America Walks , a national advocacy organization that promotes walking ... of Pittsburgh Graduate School of Public Health , has been awarded a Walking ... from around the country to participate in a four-month training program designed to strengthen ...
(Date:5/25/2016)... IN (PRWEB) , ... May 25, 2016 , ... ... group health insurance, has seen a significant spike in their clients' employee participation ... their annual biometric health screening by implementing a high-deductible health plan with outcome-based ...
(Date:5/25/2016)... GA (PRWEB) , ... May 25, 2016 , ... ... solutions builder, has announced that it will join America's leading engineers at the ... be held at the Georgia World Congress Center. , Engineers, speakers and ...
(Date:5/24/2016)... Slidell, LA (PRWEB) , ... May 24, 2016 , ... ... which will feature a unique and patented refillable hanging wipe dispenser. The campaign kick-off ... 1, 2016 and will end June 25, 2016. The goal is to raise $1,000 ...
(Date:5/24/2016)... ... May 24, 2016 , ... Fire Door Solutions, ... one resource, from start to finish, for Life Safety compliance. These expanded ... surveys requested by the Joint Commission, and fire stopping reviews, inspections, and repairs. ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... 2016  Diana Russell suffers from a form of ... inside out.  This disease has put her in a ... and grandchildren to leave her home.  Because of the ... haul the wheelchair.  So if there is a family ... is left to wait for the bus. ...
(Date:5/24/2016)... , May 24, 2016  Joe Marziani has joined VMS BioMarketing as senior vice ... officer, today. In his new role, Marziani will lead the company,s business development and ... to improve outcomes. Photo - http://photos.prnewswire.com/prnh/20160523/371089 ... ... ...
(Date:5/24/2016)... OXFORD, England , May 24, 2016 ... Practice and Education in Clinical Neurophysiology  ... medical information products and services, today announced the launch ... , an open access journal that focuses on clinical ... latest research, case reports, clinical series, normal values and ...
Breaking Medicine Technology: