Blind humans lacking rods and cones retain normal responses to non-visual effect...(ht responses such as the entrainment of ...),Health

For example, surgeons might want to think twice about removing a damaged eye that still possesses functioning pRGCs, given the important physiological role that these cells play in maintaining normally timed sleep. We will now need to begin to think about these additional functions of the human eye, and consider not just vision, but also how light affects sleep, alertness, performance, and human health. The remarkable discovery of a novel photoreceptor in the mammalian eye has shed new light on an organ that has been studied for thousands of years.

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