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Blasting cancer from the inside out
Date:12/6/2011

stead of detonating at one point, the atoms continuously disperse and emit alpha particles at increasing distances." The process takes approximately ten days, leaving only non-radioactive and non-toxic amounts of lead. The wire itself, which is initially inserted into the tumor by hypodermic needle, decays harmlessly in the body.

In pre-clinical trials on mouse models, this method has shown a distinct advantage over surgical tumor removal. One group of the mice was treated with surgical tumor removal, while another group underwent ablation treatment using the radioactive wire. When cells from the tumor were re-injected into the subject, 100 percent of those treated surgically redeveloped their tumor, compared to only 50 percent of those treated with the radioactive wire. The researchers have had excellent results with many types of cancer models, including lung, pancreatic, colon, breast, and brain tumors.

Ultimately, this shows that tumor removal by ablation increases immunity against the return of the cancerous tumor cells. "Surgery can eliminate 80 to 90 percent of a tumor, chemotherapy another 5-15 percent," says Prof. Keisari. "There are often a small number of metastatic cells left in the body, and they kill about 85% of the patients." Ablation methods, through the stimulation of specific anti-tumor immunity, have a better record for killing off the cancer cells that escape other types of treatment. It's also less invasive, more efficient, and more cost-effective.

Technology heads to trial

The treatment, called DARTTM (Diffusing Alpha-emitters Radiation Therapy), has now been commercialized by Althera Medical Ltd., co-located in Tel Aviv and New York City, and will soon undergo clinical trials at Beilinson Hospital in Israel.

According to Prof. Keisari, this is just the beginning of an emerging field of cancer treatment. He hopes to see researchers from all over the world come together to create a compreh
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Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

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