Navigation Links
Blacks With Certain Gene Need Lower Doses of Warfarin: Study
Date:6/5/2013

WEDNESDAY, June 5 (HealthDay News) -- The discovery of a genetic variation that affects how some black patients respond to the blood thinner warfarin could improve the safety and effectiveness of the drug, researchers report.

Blacks with this common genetic variation need a significantly lower dose of warfarin than those without the variation, the researchers report online June 4 in The Lancet.

"Adding this genetic marker -- found in more than 40 percent of African-American patients in the study -- to standard dosing algorithms improved the predictability of warfarin dosing by 21 percent in these individuals, which has the potential to increase the safety and effectiveness of this notoriously hard-to- dose drug," study leader Julie Johnson, of the University of Florida, said in a journal news release.

Warfarin is widely used to prevent blood clots in patients with a heart rhythm disorder called atrial fibrillation, a history of previous blood clots and after major surgery. However, it can be difficult to determine the correct dose for individual patients.

Previous research has identified two genes that explain about 30 percent of the difference in warfarin response in people of European and Asian ancestry, but these genes have less of an effect in blacks.

In this study, the researchers analyzed health information and DNA samples from hundreds of blacks and determined that there was a strong association between the rs12777823 variant on chromosome 10 and warfarin dose. The findings suggest that the dose of warfarin required by blacks with one or two copies of this variant is about 7 milligrams (mg) to 9 mg less per week than for other patients, the researchers said.

The U.S. Food and Drug Administration advocates use of genetic backgrounds to help guide warfarin dosing, Mark Alberts, of the University of Texas Southwestern Medical Center at Dallas and author of an accompanying editorial, said in the news release. "However, the practical aspects [and limitations] have not been fully appreciated.

"Genetic testing has several challenges: it is not widely available in some areas; it is costly; and clinicians often can identify the correct dose before test results are available. If these problems were corrected, the actual use of such tests might increase substantially," Alberts noted.

More information

The American Heart Association has more about warfarin.

-- Robert Preidt

SOURCE: The Lancet, news release, June 4, 2013


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. High Blood Pressure May Be Especially Lethal for Blacks
2. Hispanic lung cancer patients tend to live longer than blacks and whites
3. Blacks and Hispanics at higher risk for precancerous colorectal polyps
4. Blacks Less Likely to Get Help on Scene After Cardiac Arrest: Study
5. Eye Changes May Predict Heart Disease in Blacks With Diabetes
6. Blacks, Hispanics Have Higher Colon Polyp Risk Than Previously Thought
7. 9 in 10 Blacks With High Blood Pressure Have Early Heart Disease
8. Marriage has different meanings for blacks and whites
9. Blacks More Prone to Hypertension After Certain Strokes
10. Stress Adds to Salt Load of Some Blacks, Study Says
11. Blacks Less Likely to Stick to High Blood Pressure Diet: Study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Blacks With Certain Gene Need Lower Doses of Warfarin: Study
(Date:5/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... the Medical Director of its new DeSoto facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:5/25/2016)... ... May 25, 2016 , ... Stern Environmental Group ... be selling the device branded as Stern’s Real Time Monitoring (RTM) Device. ... to the hotel and motel industry, colleges for use in dormitories, shelters, and nursing ...
(Date:5/24/2016)... ... May 24, 2016 , ... According to an ... group of people randomly assigned to reduce the amount of calories they consumed by ... drop in body weight enjoyed better sleep, improved quality of life, and enhanced sexual ...
(Date:5/24/2016)... ... May 24, 2016 , ... BTC Media, a ... event, Distributed: Health, to be held in Nashville, Tennessee on September 7, 2016. ... 24-hour Hackathon preceding the event will host teams from around the world, competing ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... To better ... a new research award to examine gender differences in lung cancer. Today, the Lung ... Innovation Project: Lung Cancer in Women Award, funded by the American Lung Association’s LUNG ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
(Date:5/24/2016)... -- Cirujanos holandeses han puesto en marcha ... a compartir sus mejores prácticas por el mundo y ... de Europa, África, Asia y ... que combina la transmisión en vivo con mensajería instantánea ... Educación   "Imagine un médico de Medicines sans ...
(Date:5/24/2016)...   , Study met ... and superiority in , Excellent plus ... of the ascending colon   , ... B.V. today announced new positive data from the phase III MORA ... standard 2 litre PEG with ascorbate. The study met both primary ...
Breaking Medicine Technology: