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Black women with SLE develop cardiovascular disease at early age
Date:8/19/2010

without the disease. "In female SLE patients, we found a 9.6 year difference in age difference at time of hospitalization for CVD between black patients and white patients (mean age-63.5 years)," said Dr. Scalzi.

This is also the first known study to compare age at the time of CVD and CVD-related death in men with SLE to those without the disease. There were 805 male SLE patients who were admitted due to a CVD event with black or Hispanic patients being the youngest. Results indicate that men with SLE were 5.5 years younger than men without SLE at the time of admission for CVD and 11 years younger at the time of in-hospital death due to CVD.

Additionally, research showed there were 218 admissions of women with SLE where in-hospital death was attributed to a CVD event. In this group, black women were also youngest (mean age of 52.8 years) at the time of death compared with other racial groups (mean ages for white-67.1 years; Hispanic-62 years; Asian 63.8 years). Dr. Scalzi noted, "More than half of the black women with SLE who died of CVD were younger than 55 years of age. Most startling was the vast age difference between patients with SLE and their age-matched controls at the time of CVD-related death: black women with SLE were almost 20 years younger than black women without SLE (52.8 versus 72.6 years of age)."

The authors suggest that many traditional CVD risk factors (smoking, obesity, high cholesterol) are modifiable and active risk factor management should target women with SLE. Of particular concern is identification of young black and Hispanic SLE patients who are of greatest risk. "Studies in ethnically diverse lupus populations are warranted to examine the success in addressing risk factor management and barriers that may hamper effective management efforts," concluded Dr. Scalzi. "Prescription habits, adherence to prescribed therapy, awareness of heart attack warning signs, and appropriate management of acute CVD event
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Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

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