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Black women with SLE develop cardiovascular disease at early age
Date:8/19/2010

A recent study by researchers at Penn State College of Medicine found significant racial disparities in the age of systemic lupus erythematosus (SLE) patients at the time of hospital admission for cardiovascular disease (CVD) events and CVD-related death. Black women were youngest to both be admitted with CVD and to have an in-hospital death due to CVD. Results of the study appear in the September issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

Lupus is a chronic autoimmune disease where the body's own immune system attacks healthy cells and tissues, causing inflammation, extreme fatigue, joint pain, and organ damage. According to the Lupus Foundation of American approximately 1.5 million American in the U.S. have some form of lupus, with SLE representing 70% of all cases. In those patients with SLE, cardiovascular disease is a major cause of illness and mortality with recent studies suggesting 36% of all SLE-related deaths are attributed to ischemic heart disease

Using data from the Health Care Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) database, Lisabeth Scalzi, M.D., M.S., and colleagues analyzed all adult (18 years of age or older) patient records between 2003 and 2006. After eliminating records without complete demographic information, the research team identified 90,444 hospitalizations for SLE patients and roughly 19 million for subjects without SLE. Of those with SLE, 89% were women, compared with 61% in the non-SLE population. The racial composition of the SLE group was: 55% white, 28% black, 12% Hispanic, 2% Asian, and 3% other.

The team noted 3,627 admissions for acute CVD among female SLE patients with a mean age of 60.8 years. In female patients without SLE who were admitted with CVD the mean age was 71.3 years. Black women were the youngest to experience a CVD event53.9 years for those with SLE and 65.8 for those
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Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

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