Navigation Links
Black raspberries may prevent colon cancer, study finds
Date:11/2/2010

Black raspberries are highly effective in preventing colorectal tumors in two mouse models of the disease, according to a University of Illinois at Chicago study.

The findings are published in the November issue of Cancer Prevention Research.

Colorectal cancer is the third most common cancer and the second leading cause of cancer-related death in both men and women in the U.S., according to the National Cancer Institute.

Building on previous research that found black raspberries have antioxidant, anti-cancer, anti-neurodegenerative and anti-inflammatory properties, the researchers looked at the fruit's ability to prevent colon cancer.

"We saw the black raspberry as a natural product, very powerful, and easy to access," said Dr. Wancai Yang, assistant professor of pathology at the UIC College of Medicine and senior author of the study, whose research focuses on the interactions of genetic and nutritional factors in the development of intestinal cancer and tumor prevention.

The researchers used two strains of mice, Apc1638 and Muc2, which each have a specific gene knocked out, causing the mice to develop either intestinal tumors (in the case of Apc1638) or colitis in the case of Muc2. Colitis is an inflammation of the large intestine that can contribute to the development of colorectal cancer.

Both mouse strains were randomized to be fed either a Western-style, high-risk diet (high in fat and low in calcium and vitamin D) or the same diet supplemented with 10 percent freeze-dried black raspberry powder for 12 weeks.

The researchers found that in both mouse strains the black raspberry-supplemented diet produced a broad range of protective effects in the intestine, colon and rectum and inhibited tumor formation.

In the Apc1638 mice, tumor incidence was reduced by 45 percent and the number of tumors by 60 percent. The researchers found that black raspberries inhibited tumor development by suppressing a protein, known as beta-catenin, which binds to the APC gene.

In the Muc2 mice, tumor incidence and the number of tumors were both reduced by 50 percent, and black raspberries inhibited tumor development by reducing chronic inflammation associated with colitis.

The researchers now hope to obtain funding to begin clinical trials in humans, said Yang. Because black raspberries not only prevent cancer but also inflammation, they may also protect against other diseases, such as heart disease.


'/>"/>

Contact: Sherri McGinnis Gonzlez
smcginn@uic.edu
312-996-8277
University of Illinois at Chicago
Source:Eurekalert

Related medicine news :

1. Black rice bran may help fight disease-related inflammation
2. Breast-Feeding Less Common for Black Moms
3. Children, males and blacks are at increased risk for food allergies
4. Black motorcyclists -- even in helmets -- more likely to die in crashes
5. Blacks with muscular dystrophy die 10-12 years younger than whites: New study
6. Black women with SLE develop cardiovascular disease at early age
7. Black Teens May Need Higher Vitamin D Supplementation
8. Vitamin D deficiency linked to arterial stiffness in black teens
9. Why are blacks more likely to die from cancer diagnosis?
10. Blacks Seem More Vulnerable to Deadly Blood Infection
11. Wiley-Blackwell Conducts Trial of SciVee Video Platform
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... , ... Dr. Alex Rabinovich, a highly-skilled oral surgeon specializing in wisdom teeth ... insurance options. If a Bay Area patient has to search for a second opinion ... an in-network provider for a second opinion can ensure a patient receives the full ...
(Date:5/26/2017)... ... May 26, 2017 , ... ... year’s recipient of proceeds from its 14th Annual Clays for Kids fundraiser, to ... Road 30, Bennett, Colorado. , As part of BluSky’s partnership with The ...
(Date:5/26/2017)... ... 2017 , ... Water damage to the flooring of several classrooms at The ... officials with a number of critical issues to address before students could return to ... with little or no disruption to class schedules. Second, the project had to comply ...
(Date:5/24/2017)... ... May 24, 2017 , ... Dr. Alan I. Benvenisty, MD is dual board ... He is known for his distinguished expertise and experience in the diagnosis and treatment ... training in treating renovascular disease and aortic aneurysm . He is known for ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. Nicholas Rallis ... have now spent 10 years as clinical instructors for the reputable Full Mouth ... Dentistry. Through the program, private practitioners receive cutting-edge clinical training and learn how ...
Breaking Medicine News(10 mins):
(Date:5/10/2017)... Inc. (Nasdaq: HOLX ) announced today the ... April 1, 2017 .   GAAP diluted earnings per ... prior year period as the sale of the blood ... diluted EPS of $0.50 increased 6.4%.  Revenue of $715.4 ... Excluding the effects of blood screening and the acquired ...
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)...  Demonstrating its commitment to representing research- based ... Pharmaceutical Research and Manufacturers of America (PhRMA) today ... now have to meet new research and development ... join PhRMA. "By putting in place ... clear message that being a member of PhRMA ...
Breaking Medicine Technology: