Navigation Links
Black Americans Still Wary of Clinical Trials
Date:1/14/2008

Study shows distrust of researchers lingers from infamous Tuskegee experiment

MONDAY, Jan. 14 (HealthDay News) -- Black Americans continue to distrust medical research and clinical trials, apparently a lasting legacy of the infamous Tuskegee experiment which was shut down more than three decades ago, a new study shows.

Ironically, such attitudes are keeping minorities from participating in current clinical trials that could save their lives, the researchers added.

"We found that minorities are 200 percent more likely to perceive harm coming from participating in research," said senior study author Dr. Neil Powe, a professor of medicine at Johns Hopkins School of Medicine in Baltimore.

While previous studies had shown that black Americans and other minorities are less likely to be enrolled in clinical trials, this study, appearing in Jan. 14 online issue of Medicine, helps explain why.

"This is new knowledge, obtained with appropriate methods in a large sample," said Dr. William Cunningham, a professor of medicine and public health at the UCLA School of Medicine. "This study provides direct evidence that distrust of researchers explains the lower participation of blacks in cardiovascular prevention trials research. This looks like an important study."

"This provides a database to support what we think is going on with respect to concerns of the minority community," said Dr. James Powell, principal investigator of Project IMPACT (Increase Minority Participation and Awareness in Clinical Trials). The project is a program of the National Medical Association, which represents black physicians and their patients. "Mistrust comes up not only with respect to clinical trials, but also with respect to interacting with the medical establishment. This leads to people not seeing a physician when they really need to."

Black Americans tend to be under-represented in clinical trials, which are responsible for most advances in medicine.

This discrepancy is particularly unfortunate, because not only do black Americans suffer disproportionately from many health conditions, they often experience illnesses differently and respond differently to medications, making race-specific trials even more crucial, the researchers noted.

"We're concerned that the lack of minority representation in clinical trials may perpetuate health disparities," Powell said.

Previous studies have shown that this under-representation is, in fact, due to individuals' unwillingness to participate, as opposed to researchers' exclusion of minorities.

And this unwillingness is widely thought to be due to the legacy of Tuskegee and other such research. The government-sponsored Tuskegee Study, named after a town in Alabama where participants were recruited, enrolled several hundred poor, black sharecroppers, telling them that they would receive drugs to treat their syphilis infections. But lifesaving drugs were purposely withheld so the "natural" course of the disease could be observed. The experiment was shut down after a leak to the press in 1972.

In this latest study, Powe and his colleagues conducted a random survey of 717 outpatients at 13 cardiology and general medicine clinics in Maryland. Thirty-six percent of participants were black, the rest white.

After an in-depth explanation by a physician (either black or white), each participant was asked to enroll in a mock trial of a cardiovascular drug.

Only 27 percent of black American respondents were willing to participate, versus 39 percent of whites.

Among the study's other findings:

  • 24 percent of black Americans reported that their doctors would not fully explain research participation to them, versus 13 percent of whites.
  • 72 percent of black Americans said doctors would use them as guinea pigs without their consent, versus 49 percent of whites.
  • 35 percent of black Americans said doctors would ask them to participate in research even if it could harm them, versus only 16 percent of whites.
  • 8 percent of black Americans more often believed they could less freely ask questions of doctors, compared with 2 percent of whites.
  • 58 percent of black Americans said doctors had previously experimented on them without consent, compared with 25 percent of whites.

When the element of distrust was removed from the equation, the proportions of blacks and whites willing to enroll equalized to about a third of those sampled in both racial groups.

The good news is that there are ways to remedy the situations.

"One is physician or researcher relationships and interactions, that physicians and researchers should be taking the time to talk to patients and communicate with them explaining the risk of being involved in medical research and dispelling myths about participating in research," Powe said. "It's hard to do in a busy medical environment today but necessary."

Academic medical centers need also to build relationships that engender trust with the community, even including community members in designing research studies.

Finally, Powe said, patients tend to trust physicians of the same race. "One big issue is that there are not enough minority physicians, so that's a societal remedy we all have to think about," Powe said.

Some 12 percent of the U.S. population is black, but only 4 percent of physicians are black.

More information

The National Cancer Institute has more on minority participation (or lack thereof) in clinical trials.



SOURCES: Neil R. Powe, M.D., M.P.H., M.B.A., professor, medicine, Johns Hopkins School of Medicine, Baltimore; William E. Cunningham, M.D., professor, medicine and public health, UCLA School of Medicine, Los Angeles; James Powell, M.D., principal investigator, Project Impact Program, National Medical Association; Jan. 14, 2008, Medicine


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Blacks, Hispanics less likely to get strong pain drugs in emergency rooms
2. BRCA1 Mutation Prevalent Among Hispanic, Younger Black Women
3. Breast cancer gene mutation more common in Hispanic, young black women, Stanford/NCCC study finds
4. Ortho Organizers(R) Introduces Product Line Extension - Rectangular Super Elastic Nitanium(R) Black Ti(TM) Archwire
5. Blackberries, Broccoli Sprouts Battle Cancer
6. Black Women Wait Longer for Breast Cancer Surgery
7. Wiley-Blackwell and U. of Penn Health Systems Center for Evidence-Based Practice launch InfoPOEMs
8. Cookie Johnson and Abbott Bring I Stand With Magic: Campaign to End Black AIDS to Los Angeles to Educate African-American Women on HIV/AIDS
9. The Magic Johnson Foundation and Abbott Expand Focus of Campaign to End Black AIDS to African-American Women in 2008
10. Studies Reveal Why Breast Cancer Hits Black Women Harder
11. Wiley-Blackwell to relaunch InfoPOEMs with InfoRetriever
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Black Americans Still Wary of Clinical Trials
(Date:10/13/2017)... , ... October 13, 2017 , ... As health professionals ... known as “patient engagement.” The patient is doing more than filling out a survey; ... , “There is an increasing emphasis in health care and research on the importance ...
(Date:10/13/2017)... EDWARDSVILLE, Ill. (PRWEB) , ... ... ... University Edwardsville School of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and ... educated healthcare professionals on guideline updates for the primary prevention of cardiovascular ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Ellevate Network, ... in business to advocate for action towards gender equality at their inaugural Summit in ... around the globe, and reached a social audience of over 3 million. To watch ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... ... 12, 2017 , ... The company has developed a suite ... regulatory authorities worldwide. From Children’s to Adults 50+, every formula has been developed ... , These products are also: Gluten Free, Non-GMO, Vegan, Soy Free, Non-Dairy*, ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... -- AVACEN Medical , Inc. (AVACEN) announced that Frost ... Product Innovation Award for Its fibromyalgia pain management device. ... device market research by Frost & Sullivan,s industry experts. ... relief product, the AVACEN 100, offers a safe and effective ... ...
(Date:10/12/2017)... , Oct. 12, 2017 West ... in innovative solutions for injectable drug administration, today announced ... the market opens on Thursday, October 26, 2017, and ... results and business expectations at 9:00 a.m. Eastern Time. ... or 253-336-8738 (International). The conference ID is 94093362. ...
(Date:10/11/2017)... -- Caris Life Sciences ® , a leading innovator in ... medicine, today announced that St. Jude Medical Center,s Crosson ... as its 17 th member. Through participation with ... Institute will help develop standards of care and best ... cancer treatment more precise and effective. ...
Breaking Medicine Technology: