Navigation Links
Bitter melon juice prevents pancreatic cancer in mouse models
Date:3/12/2013

A University of Colorado Cancer study published this week in the journal Carcinogenesis shows that bitter melon juice restricts the ability of pancreatic cancer cells to metabolize glucose, thus cutting the cells' energy source and eventually killing them.

"Three years ago researchers showed the effect of bitter melon extract on breast cancer cells only in a Petri dish. This study goes much, much farther. We used the juice people especially in Asian countries are already consuming it in quantity. We show that it affects the glucose metabolism pathway to restrict energy and kill pancreatic cancer cells," says Rajesh Agarwal, PhD, co-program leader of Cancer Prevention and Control at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences.

Agarwal's interest came from connecting the dots of existing research in a novel way. See, diabetes tends to presage pancreatic cancer and bitter melon has been shown to effect type-II diabetes, and has been used for centuries against diabetes in the folk medicines of China and India. Following this line of thinking, Agarwal and colleagues wondered what would happen if they closed out the middle man of diabetes and directly explored the link between bitter melon and pancreatic cancer.

The result, Agarwal says, is, "Alteration in metabolic events in pancreatic cancer cells and an activation of the AMP-activated protein kinase, an enzyme that indicates low energy levels in the cells."

Perhaps not coincidentally, bitter melon also regulates insulin secretion by pancreatic beta cells. After studies in cell cultures, the group showed that mouse models of pancreatic cancer that were fed bitter melon juice were 60 percent less likely to develop the disease than controls.

"It's a very exciting finding," Agarwal says. "Many researchers are engineering new drugs to target cancer cells' ability to supply themselves with energy, and here we have a naturally-occurring compound that may do just that."

The Agarwal Lab is now applying for grants that will allow them to move the study of bitter melon into further chemoprevention trials in mouse models of pancreatic cancer.


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Explaining Stevias bitter side
2. Evans Consulting Services Announced Bioavailability of Juice PLUS+ Has Been Confirmed by Twelve Universities Around the World
3. Grapefruit Juice May Give Boost to Cancer Treatment: Study
4. More Proof Cranberry Juice Thwarts Infection
5. Hope in stopping melanoma from spreading: Inhibiting protein prevents metastasis to lungs in mice
6. Rugged iPad Case Prevents Damage and Adds Branding Option for Businesses
7. Poor sleep in old age prevents the brain from storing memories
8. High fiber diet prevents prostate cancer progression
9. A carefully scheduled high-fat diet resets metabolism and prevents obesity
10. Treated Vaginal Ring Prevents HIV in Monkeys
11. Pitt: Targeted oxidation-blocker prevents secondary damage after traumatic brain injury
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... A new partnership between Goodwill® and Roadie, Inc. ... or need, from clothes to couches to dressers and bicycles. Roadie — the national ... the nearest Goodwill donation center through February 28th. , “January is an exciting ...
(Date:1/20/2017)... ... 2017 , ... Bionic Sports Nutrition LLC, an American company devoted to developing ... successful January ECRM Trade Show in Hilton Head, SC. , Bionic Sports Nutrition ... provide its products to all clients at reasonable prices. At the ECRM trade show, ...
(Date:1/20/2017)... ... ... Michael and Betsy Brauser celebrated 5 years of Betsy’s participation in a ... has been life-saving as she has been on the trial for more than six ... ovarian cancer in 2009. She underwent standard chemotherapy but a year later went to ...
(Date:1/20/2017)... ... ... “The Angel”: a heartwarming and earnest tale of faith and believing in the ... is the creation of published author, Marjorie Lund-Fontaine, a former professional violinist, alumnus of ... asked of her new book, Marjorie says, “‘The Angel’ was written as a fairytale, ...
(Date:1/20/2017)... ... 20, 2017 , ... “Christmas in Suffolk”: a story of love, secrets, ... lives in Lafayette, Indiana where she works in a daycare and looks for inspiration ... Published by Christian Faith Publishing, Sara Seymour’s new book is an adventure of love ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... BOCA RATON, Fla. , Jan. 19, 2017 ... ), a medical device company specializing in the ... conditions, such as keloids, with superficial radiation therapy, ... quarter and full year 2016 financial results on Thursday, ... The Company will hold a conference call ...
(Date:1/19/2017)... Pfizer joins Astex, AstraZeneca, ... Consortium   Major research investment to ...   The Milner Therapeutics Institute today ... a partner to the Milner Therapeutics Consortium. Pfizer has ... transfer of materials between industry and academia and allocation ...
(Date:1/19/2017)... , , Marks E-QURE , ... distribution agreement, following similar agreements in Israel and ... $2 5 billion global market ... EQUR), a leader in medical devices for the treatment of advanced wound care, ... S.A.S. (TeckMedica) in Colombia for the Company,s patented Bio-electrical ...
Breaking Medicine Technology: