Navigation Links
Bitter Taste Receptors Found in Lungs May Aid Asthma Patients

SUNDAY, Oct. 24 (HealthDay News) -- Bitter taste receptors are located in the lungs as well as on the tongue, a finding that might lead to improved treatments for asthma and other obstructive lung diseases, according to researchers at the University of Maryland School of Medicine in Baltimore.

"The detection of functioning taste receptors on smooth muscle of the bronchus in the lungs was so unexpected that we were at first quite skeptical ourselves," said the study's senior author, Dr. Stephen B. Liggett, professor of medicine and physiology and director of the university's cardiopulmonary genomics program, in a university news release.

The receptors in the lungs -- which the team found by accident in an unrelated study -- are the same as those on the tongue. But the tongue's receptors are clustered in taste buds that send signals to the brain, while the receptors in the lungs are not grouped in buds and don't send signals to the brain, explained the research team. However, they still respond to bitter tastes.

The researchers tested different bitter compounds on human and mouse airways, individual airway smooth muscle cells, and on mice with asthma. They found that these compounds all opened lung airways more profoundly than current drugs.

The study appears online Oct. 24 in the journal Nature Medicine.

"New drugs to treat asthma, emphysema or chronic bronchitis are needed. This could replace or enhance what is now in use, and represents a completely new approach," said Liggett.

But, he added, simply eating bitter-tasting foods or compounds won't help people with asthma.

"Based on our research, we think that the best drugs would be chemical modifications of bitter compounds, which would be aerosolized and then inhaled into the lungs with an inhaler," he said.

The research, which is preliminary, was supported by grants from the U.S. National Heart, Lung, and Blood Institute of the National Institutes of Health.

More information

The U.S. National Heart, Lung, and Blood Institute has more about asthma.

-- Robert Preidt

SOURCE: University of Maryland Medical Center, news release, Oct. 24, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Bitrex Bitter Safety Additive Exhibiting at the Safe Kids Fair 2010; Making a Bitter Face to Learn about Poisoning Prevention
2. Bitter Melon Extract May Slow, Stop Breast Cancer
3. Bitter melon extract decreased breast cancer cell growth
4. Bitter melon extract attacks breast cancer cells
5. Salmon baby food? Babies need omega-3s and a taste for fish, scientist says
6. European Urology: Editorial about REDUCE trial underlines value of dutasteride
7. The Science Behind Musical Taste
8. Carrousel Yacht: Miami Private Yacht Charters With Style, Taste and Value
9. Bodys Response to Foods Smell, Taste Could Be Diabetes Risk Factor
10. Oral Cancer Foundation founder named Survivor Circle Award winner
11. New method is found for accurate diagnosis of gall bladder cancer, 1 of the most deadly
Post Your Comments:
Related Image:
Bitter Taste Receptors Found in Lungs May Aid Asthma Patients
(Date:11/26/2015)... ... November 26, 2015 , ... CognisantMD and Cambridge Memorial ... in the Waterloo region. Using the Ocean Platform, family physicians can now order ... electronic medical record (EMR) without the need for redundant patient entry or an ...
(Date:11/26/2015)... ... , ... The Catalent Applied Drug Delivery Institute today announced ... form selection in early phase drug development. The first of these is to ... the UK’s emerging life sciences companies, corporate partners, and investors, at Milton Park, ...
(Date:11/26/2015)... ... 26, 2015 , ... PRMA Plastic Surgery is updating their record books yet ... 6,000th free flap breast reconstruction surgery! , “What an accomplishment for the PRMA team, ... lives and it’s an honor to have served all of these women.” , PRMA ...
(Date:11/26/2015)... Viejo, CA (PRWEB) , ... November 26, 2015 ... ... users a new set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This ... style options. These classically-influenced trailer titles work with any font, giving users limitless ...
(Date:11/26/2015)... ... November 26, 2015 , ... Indosoft Inc., developer and distributor of ... server to improve system efficiency and reliability. , The new Q-Suite 6 platform is ... the system avoids locking itself into a specific piece of software for many key ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 /PRNewswire/ ... --> adds "Global ... and "Investigation Report on China Repaglinide ... 2021 forecasts data and information to ... . --> ...
(Date:11/25/2015)... 25, 2015 ... the "Global Brain Monitoring Devices Market ... --> ) has announced the ... Devices Market 2015-2019" report to their ... ( ) has announced the addition ...
(Date:11/25/2015)... N.C. , Nov. 25, 2015 ... the planned investment of at least $15.8  Million ... Wilmington, NC . The expansion ... capacity to meet the growing demands of the ... site expansion will provide up to ...
Breaking Medicine Technology: