Navigation Links
Bisphenol A (BPA) at very low levels can adversely affect developing organs in primates

COLUMBIA, Mo. Bisphenol A (BPA) is a chemical that is used in a wide variety of consumer products, such as resins used to line metal food and beverage containers, thermal paper store receipts, and dental composites. BPA exhibits hormone-like properties, and exposure of fetuses, infants, children or adults to the chemical has been shown to cause numerous abnormalities, including cancer, as well as reproductive, immune and brain-behavior problems in rodents. Now, researchers at the University of Missouri have determined that daily exposure to very low concentrations of BPA by pregnant females also can cause fetal abnormalities in primates.

"BPA is an endocrine disrupting chemical that has been demonstrated to alter signaling mechanisms involving estrogen, androgen and thyroid hormones," said Frederick vom Saal, Curators Professor of Biological Sciences in the College of Arts and Science at MU. "Previous studies in rodents have demonstrated that maternal exposure to very low doses of BPA can significantly alter fetal development, resulting in a variety of adverse outcomes in the fetus. Our study is one of the first to show this also happens in primates."

Although BPA is considered a toxic chemical in other countries such as Canada, the U.S. has been slow to address the issue, said vom Saal. Until now, most studies involving BPA have been conducted on laboratory mice and rats, leading U.S. regulatory agencies to call for studies in primates. With funding provided by the National Institute of Environmental Health Sciences (NIEHS), a research institute of the National Institutes of Health, vom Saal and his colleagues studied the chemical's blood levels in pregnant female rhesus monkeys and their fetuses, which are considered to be very similar to human fetuses.

After collecting tissue samples, other researchers analyzed the tissues to determine if BPA exposure was harmful to fetal development. Researchers found evidence of significant adverse effects in mammary glands, ovaries, brain, uterus, lung and heart tissues in BPA exposed fetus when compared to fetuses not exposed to BPA. The abnormalities were caused by levels of BPA in the monkey fetuses that were very similar to levels reported in previous studies of BPA in human fetuses.

"The very low-level exposure to BPA we delivered once a day to the rhesus monkeys is far less than the BPA levels humans are exposed to each day, which reflects multiple exposures," vom Saal said. "Our findings suggest that traditional toxicological studies likely underestimate actual human exposure and show, unequivocally, that biologically active BPA passes from the mother to the fetus. Additionally, our latest study shows that BPA causes damage to developing systems of monkey fetuses, and this is of great concern for human fetuses."

Contact: Jeff Sossamon
University of Missouri-Columbia

Related medicine news :

1. Bisphenol A is affecting us at much lower doses than previously thought
2. Harmful effects of bisphenol A proved experimentally
3. Hypnosis therapy shown to decrease fatigue levels in breast cancer patients
4. Low levels of pro-inflammatory agent help cognition in rats
5. GameStop Levels Up To Cherwell Service Management
6. RF Safe List of Lowest Radiation Cell Phones by Specific Absorption Rate (SAR) Levels
7. How to Increase Testosterone Levels Naturally Discussed in New Video by Diet Recommendations
8. In Light of Increased Levels of Personal Stress Over the Holiday Season, Lanahan Insurance Recommends Staying Covered with Health Insurance
9. A New “15 Blood Sugar Control Tips” Article Teaches People How To Control Their Blood Sugar Levels Naturally – V-kool
10. A New “11 Ways To Increase Testosterone” Article Helps Men Boost Testosterone Levels Naturally – V-kool
11. Bilateral Biomet Hip Implants Cause Maryland Man Severe Pain, Elevated Metal Ion Levels, and Revision Surgeries, Alleges Lawsuit Filed by Parker Waichman LLP
Post Your Comments:
Related Image:
Bisphenol A (BPA) at very low levels can adversely affect developing organs in primates
(Date:11/25/2015)... ... November 25, 2015 , ... Beddit® has launched a new Android app ... new app features a more intuitive SleepScore™ that rates sleep quality on a 100-point ... SleepScore is created by a proprietary algorithm. Beddit analyzes the data to provide an ...
(Date:11/25/2015)... ... November 25, 2015 , ... In an ongoing Clinical ... Center (RMC) in Chicago, IL, UV Angel is evaluating the efficacy of its product ... intensive care units (totaling 30 beds) from May 2014 through October 2015 at a ...
(Date:11/25/2015)... ... , ... Today, Mothers Against Drunk Driving (MADD) learned that the ... the first time since 2011. In 2014, there were 9,967 fatalities involving an alcohol ... National Highway Traffic Safety Administration (NHTSA), 32,675 people were killed in traffic crashes in ...
(Date:11/25/2015)... ... November 25, 2015 , ... In ... nation’s Periwinkle Pioneers, individuals and groups responsible for advancing care for pulmonary hypertension ... Pioneers, nominated by the public, will receive special recognition throughout 2016 as part ...
(Date:11/25/2015)... ... November 25, 2015 , ... Privately owned Contract Development ... expansion of its current state of the art research, development and manufacturing facility ... increase its manufacturing capacity as well as to support its clients’ growing research ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , November 25, 2015 ... Investors"), pursuant to which BioLight and the New Investors ... Ltd. subsidiary ("IOPtima") via a private placement. The financing ... its innovative IOPtimate™ system used in the treatment of ... pathway process for the IOPtimate™ system with the U.S. ...
(Date:11/25/2015)... 25, 2015 --> ... eine Lizenz für das Patent über eine neue Hepatitis-B-Behandlung, ... ENS-Lyon innehaben, an Enyo Pharma vergeben haben. ... Leben gerufenen und von Edelris gemeinsam mit seinen Partnern ... Behandlungsziel für HBV identifiziert, und es wurden neue Inhaltsstoffe ...
(Date:11/24/2015)... Calif. , Nov. 24, 2015 /PRNewswire/ ... leader in non-invasive genetic testing and the ... that it will present at the 27 ... York on Wednesday, December 2, 2015 at 1:00 p.m. ET.  Matthew Rabinowitz, ... Company,s financial results, business activities and financial ...
Breaking Medicine Technology: