Navigation Links
Bisphenol A (BPA) at very low levels can adversely affect developing organs in primates
Date:2/27/2014

COLUMBIA, Mo. Bisphenol A (BPA) is a chemical that is used in a wide variety of consumer products, such as resins used to line metal food and beverage containers, thermal paper store receipts, and dental composites. BPA exhibits hormone-like properties, and exposure of fetuses, infants, children or adults to the chemical has been shown to cause numerous abnormalities, including cancer, as well as reproductive, immune and brain-behavior problems in rodents. Now, researchers at the University of Missouri have determined that daily exposure to very low concentrations of BPA by pregnant females also can cause fetal abnormalities in primates.

"BPA is an endocrine disrupting chemical that has been demonstrated to alter signaling mechanisms involving estrogen, androgen and thyroid hormones," said Frederick vom Saal, Curators Professor of Biological Sciences in the College of Arts and Science at MU. "Previous studies in rodents have demonstrated that maternal exposure to very low doses of BPA can significantly alter fetal development, resulting in a variety of adverse outcomes in the fetus. Our study is one of the first to show this also happens in primates."

Although BPA is considered a toxic chemical in other countries such as Canada, the U.S. has been slow to address the issue, said vom Saal. Until now, most studies involving BPA have been conducted on laboratory mice and rats, leading U.S. regulatory agencies to call for studies in primates. With funding provided by the National Institute of Environmental Health Sciences (NIEHS), a research institute of the National Institutes of Health, vom Saal and his colleagues studied the chemical's blood levels in pregnant female rhesus monkeys and their fetuses, which are considered to be very similar to human fetuses.

After collecting tissue samples, other researchers analyzed the tissues to determine if BPA exposure was harmful to fetal development. Researchers found evidence of significant adverse effects in mammary glands, ovaries, brain, uterus, lung and heart tissues in BPA exposed fetus when compared to fetuses not exposed to BPA. The abnormalities were caused by levels of BPA in the monkey fetuses that were very similar to levels reported in previous studies of BPA in human fetuses.

"The very low-level exposure to BPA we delivered once a day to the rhesus monkeys is far less than the BPA levels humans are exposed to each day, which reflects multiple exposures," vom Saal said. "Our findings suggest that traditional toxicological studies likely underestimate actual human exposure and show, unequivocally, that biologically active BPA passes from the mother to the fetus. Additionally, our latest study shows that BPA causes damage to developing systems of monkey fetuses, and this is of great concern for human fetuses."


'/>"/>
Contact: Jeff Sossamon
sossamonj@missouri.edu
573-882-3346
University of Missouri-Columbia
Source:Eurekalert  

Related medicine news :

1. Bisphenol A is affecting us at much lower doses than previously thought
2. Harmful effects of bisphenol A proved experimentally
3. Hypnosis therapy shown to decrease fatigue levels in breast cancer patients
4. Low levels of pro-inflammatory agent help cognition in rats
5. GameStop Levels Up To Cherwell Service Management
6. RF Safe List of Lowest Radiation Cell Phones by Specific Absorption Rate (SAR) Levels
7. How to Increase Testosterone Levels Naturally Discussed in New Video by Diet Recommendations
8. In Light of Increased Levels of Personal Stress Over the Holiday Season, Lanahan Insurance Recommends Staying Covered with Health Insurance
9. A New “15 Blood Sugar Control Tips” Article Teaches People How To Control Their Blood Sugar Levels Naturally – V-kool
10. A New “11 Ways To Increase Testosterone” Article Helps Men Boost Testosterone Levels Naturally – V-kool
11. Bilateral Biomet Hip Implants Cause Maryland Man Severe Pain, Elevated Metal Ion Levels, and Revision Surgeries, Alleges Lawsuit Filed by Parker Waichman LLP
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bisphenol A (BPA) at very low levels can adversely affect developing organs in primates
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... addition of the "Structural Electronics 2015-2025: Applications, ... In-Mold Electronics, Smart ... Integrated Photovoltaics Structural electronics involves ... as load-bearing, protective structures, replacing dumb structures such ...
(Date:6/24/2016)... According to a new market ... Needles, Safety Pen Needles), Needle Length (4mm, 5mm, 6mm, ... of Purchase (Retail, Non-Retail) - Trends & Global Forecasts ... market for the forecast period of 2016 to 2021. ... by 2021 from USD 1.65 Billion in 2016, growing ...
(Date:6/23/2016)... , June 23, 2016 Research and ... Global Market - Forecast to 2022" report to their ... treatment method for the patients with kidney failure, it replaces ... fluid from the patient,s blood and thus the treatment helps ... and chloride in balance. Increasing number of ...
Breaking Medicine Technology: