Navigation Links
Bipolar and pregnant
Date:11/1/2013

CHICAGO --- New Northwestern Medicine research offers one of the first in-depth studies of how physiological changes during pregnancy reduce the effects of a commonly used drug to treat bipolar disorder, making women more vulnerable to recurring episodes. The new findings will help psychiatrists and physicians prevent bipolar manic and depressive symptoms during pregnancy, which are risky for the health of the mother and her unborn child.

When a woman with bipolar disorder becomes pregnant, she and her physician often don't realize her medication needs adjusting to prevent the symptoms from coming back a higher risk during pregnancy. There also is little information and research to guide dosing for psychiatric medications during pregnancy.

Approximately 4.4 million women in the U.S. have bipolar disorder with women of childbearing age having the highest prevalence.

The new study shows the blood concentration of the commonly used drug lamotrigine decreases in pregnant women. About half of the women in the study had worsening depressive symptoms as their lamotrigine blood levels dropped. The drug levels fall because women have increased metabolism during pregnancy.

"Now physicians change the dose of the drug in response to women's symptoms worsening," said lead investigator Crystal Clark, M.D., an assistant professor of psychiatry and behavioral sciences at Northwestern University Feinberg School of Medicine and a psychiatrist at Northwestern Memorial Hospital. "We need to optimize their medication dosing so they stay well."

The study results will help physicians understand how to increase their patients' doses during pregnancy and then reduce them postpartum to avoid toxicity, Clark said. Guidelines for prescribing the drug for pregnant women with the disorder also are included.

The study was published Nov. 1 in the American Journal of Psychiatry.

Depressive episodes -- as opposed to manic -- are most likely to recur in pregnant women with bipolar disorder.

"The safety of the fetus is at risk," Clark said. "Pregnant women that are depressed are less likely to take care of themselves which often leads to poor nutrition, lack of compliance with prenatal care and isolation from family and friends. It has also been linked to premature births and babies with low birth weights among other poor birth outcomes."


'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Related medicine news :

1. Predictors of substance abuse identified among teens with bipolar disorder
2. Neuroimaging may offer new way to diagnose bipolar disorder
3. Flu in pregnancy may quadruple childs risk for bipolar disorder
4. Study Sees Link Between Moms Flu, Bipolar Risk for Children
5. Bipolar Disorder Drugs May Tweak Genes Affecting Brain
6. The hunt for a successor to lithium for bipolar disorder
7. Family intervention improves mood symptoms in children and adolescents at risk for bipolar disorder
8. Pitt study examines cost-effectiveness of medicare drug plans in schizophrenia and bipolar disorder
9. How do happiness and sadness circuits contribute to bipolar disorder?
10. Brain Scans Might Help Spot Risk for Bipolar Disorder
11. Pregnant Women With Bipolar Disorder May Have Higher Risk of Premature Birth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2017)... ... July 23, 2017 , ... Scientists from the ... underwent brief bursts of high-intensity, weight-bearing activity equivalent to a medium-paced run for pre-menopausal ... an orthopaedic surgeon who specializes in total spine care, I understand the importance exercise ...
(Date:7/23/2017)... ... , ... “I Am Not Nothin’: The Serpent Handler’s Daughter” is a compelling ... write and a brokenhearted young soldier who turned to whiskey after his return from ... power of simple faith is the work of published author Tommy G. Robertson, a ...
(Date:7/22/2017)... ... , ... Reassured For Life ( http://www.reassured.ca ), is now open. , “Reassured ... broker Nerissa McNaughton. “I launched this firm because I know talking about life, accident, ... conversation. I make it easy. As a broker I have access to all the ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Bryant Agency, ... families and business owners in the Dalton region, is working in conjunction with ... sexual assault and physical abuse. , The GreenHouse is headquartered in Dalton and ...
(Date:7/21/2017)... ... July 21, 2017 , ... The Karen Miller Agency, a ... in the greater Birmingham area, is joining the Chris Hammond Youth Foundation in ... the region. , The Chris Hammond Youth Foundation maintains athletic facilities in rural ...
Breaking Medicine News(10 mins):
(Date:7/19/2017)... 19, 2017  Mako Medical Laboratories partnered with Secretary ... Family Assistance Fund (MFA) to bring 140 soldiers back ... with their families one last time before being deployed. ... travel and logistics needed for these soldiers. "Mako Medical ... their families. We just wish we could bring them ...
(Date:7/14/2017)... , July 14, 2017 Endo International plc (NASDAQ: ... Tuesday, August 8, 2017.  Members of its senior management team will ... open at 8:30 a.m. ET. The dial-in number ... 497-0462, International (678) 509-7598, and the passcode is 45397076. Please dial ... A replay of the call will ...
(Date:7/13/2017)... RK Logistics Group, Inc. was awarded ... Fremont, CA headquarters facility where it ... San Jose for hi-tech, pharmaceutical and ... , with its Fremont Innovation District, is excited to strategically ... resource to the hundreds of biotech, pharma and biomed companies ...
Breaking Medicine Technology: