Navigation Links
Bipolar Disorder Drugs May 'Tweak' Genes Affecting Brain
Date:4/25/2013

By Barbara Bronson Gray
HealthDay Reporter

THURSDAY, April 25 (HealthDay News) -- Medications taken by people with bipolar disorder may actually be nudging hundreds of genes that direct the brain to behave more normally, according to new research.

The study suggests that antipsychotic drugs activate a wide range of genes, changing their function, said lead author Dr. Melvin McInnis.

"A gene's activity in any given cell will vary depending on what it's exposed to," said McInnis, a professor of bipolar disorder and depression at the School of Medicine at the University of Michigan.

It's not often that scientists stumble upon something in research that they totally weren't expecting to see. "It was a major surprise to us that people treated with an antipsychotic [medication] had changes in the gene expression pattern," McInnis said.

The findings could help point the way to new gene-targeted and stem cell therapies, and provide valuable insight into what causes manic-depressive mood swings, he added.

However, a genetics expert not connected to the study was more cautious about drawing implications from its findings.

Bipolar disorder, also known as manic-depressive illness, affects about 5.7 million American adults, or about 2.6 percent of the U.S. population aged 18 and older, according to the U.S. National Institute of Mental Health (NIMH). The brain disorder causes severe and unusual shifts in mood, energy, activity levels, and the ability to carry out routine daily tasks.

The new research, published in a recent issue of the journal Bipolar Disorders, involved examining 26 brains donated to a nonprofit brain bank. Fourteen of the brains were from people who had bipolar disorder. Of those, seven were from people who had been taking one or more antipsychotic medications -- such as clozapine, risperidone and haloperidol -- when they died. Twelve brains were from those with no
'/>"/>

Copyright©2012 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Ketamine improved bipolar depression within minutes
2. Radio Guest Karen Tyrrell to Share her Story of Bipolar Disorder and Recovery
3. Family History of Schizophrenia, Bipolar Disorder May Up Kids Risk for Autism
4. Mount Sinai finds common factors in autism spectrum disorders, schizophrenia, and bipolar disorder
5. Pregnant Women With Bipolar Disorder May Have Higher Risk of Premature Birth
6. Brain Scans Might Help Spot Risk for Bipolar Disorder
7. How do happiness and sadness circuits contribute to bipolar disorder?
8. Pitt study examines cost-effectiveness of medicare drug plans in schizophrenia and bipolar disorder
9. Family intervention improves mood symptoms in children and adolescents at risk for bipolar disorder
10. The hunt for a successor to lithium for bipolar disorder
11. Bascom Palmer Eye Institute announces breakthrough for degenerative vision disorder
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Bipolar Disorder Drugs May 'Tweak' Genes Affecting Brain
(Date:12/25/2014)... AngelWeddingDress.com tries its best to translate ... Today, the business has introduced its new collection of ... promotion. , The new prom outfits are guaranteed to ... lover. They are specially designed for 2015. Anyone who ... should visit its website before Jan. 26, 2015, the ...
(Date:12/25/2014)... Residents at Abernethy Laurels ... their generous spirit by providing holiday gifts to ... Network- Grandparents Raising Grandchildren program. , Following a ... largest Christmas tree on the campus of the ... of the Abernethy Village Association (AVA). Each holiday ...
(Date:12/24/2014)... 2014 Over 700 toys, that’s what ... communities. That is 700 smiling little faces this holiday ... over $6000 in monetary donations was given to the ... the expenses they incur through the year. Some of ... A Child's Haven , Shrine's Children's Hospitals, Toys for ...
(Date:12/24/2014)... 2014 Risperdal lawsuit ( http://www.risperdallawsuit2014.com/ ) ... litigation currently underway in Pennsylvania’s Philadelphia Court of Common ... 24, 2014, court documents indicate that 1,183 claims had ... who developed gynecomastia (male breast growth) and other complications ... indicates that this represents an increase of more than ...
(Date:12/24/2014)... December 25, 2014 Today, UWDress.com, the famous ... sleeve wedding gowns, and launched a site-wide wedding gown promotion. ... sleeve wedding gowns in a more unexpected way, the collection ... are popular in the global market, and they are available ... UWDress.com are offered at discounted prices, up to 75% off; ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Retirement Community Residents Make Impact During Holiday Season 2Health News:AlignLife Donates Over 700 Toys This Year 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 2Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 3Health News:Risperdal Lawsuits Continue to Climb, as Claims in Pennsylvania Litigation Exceed 1,180 Filings, Bernstein Liebhard LLP Reports 4Health News:Buy Cheap Long Sleeve Wedding Gowns At UWDress.com 2
... The New AfterShingles.com Helps Educate Consumers About Shingles ... The Visiting Nurse Associations of America (VNAA), the ... on Aging (NCOA) today announced the re-launch of ... to help educate consumers about shingles and postherpetic ...
... awareness by exploring solutions to the most common health problem ... The causes and treatments of enlarged prostate will be ... 2009 at 6:30pm at the Doubletree Hotel in Rosemead. Also ... the prostate affects more than half of all men over ...
... AVAILABLE -SEATTLE, March 31 The sister ... mucous causing oxygen loss and brain damage while she ... Center in Edmonds, Wash., has filed suit against three ... Extendicare REIT. Norene McPherson,s 49-year-old sister, Lea Ann, died ...
... March 31 HealthWorldWeb , the premiere Health 2.0 ... appointment of Michael L. Millenson and J.D. Kleinke to the ... in the industry as supporters and advisors strengthens our belief ... 2.0 personalization is a very real need," said Daniel Kogan, ...
... separate cancer from benign mole, scientists say , , TUESDAY, ... melanoma skin cancer and a harmless mole can still ... But scientists say differences in levels of certain genetic ... Melanoma is the deadliest form of skin cancer. Standard ...
... Georgetown University Medical Center (GUMC) have been able to ... cord injury in preclinical studies. , Their research, published ... by Kimberly Byrnes, PhD, shows that inflammation following injury ... damage, and that an experimental agent is able to ...
Cached Medicine News:Health News:New, Interactive Health Web Site Provides Information About a Painful and Often Debilitating Condition Affecting Older Americans 2Health News:New, Interactive Health Web Site Provides Information About a Painful and Often Debilitating Condition Affecting Older Americans 3Health News:Elder Abuse Complaint Filed Against Extendicare 2Health News:Elder Abuse Complaint Filed Against Extendicare 3Health News:HealthWorldWeb Adds Michael Millenson and J.D. Kleinke to Board of Advisors 2Health News:Gene Screen Could Help Spot Melanoma 2Health News:By shutting down inflammation, agent reverses damage from spinal cord injury in preclinical studies 2
(Date:12/24/2014)... Dec. 24, 2014 Kinex Pharmaceuticals announced today ... at Roswell Park Cancer Institute. KX2-361 (KX02), ... that has shown potent inhibitory activity against a broad ... are resistant to Temozolomide (T98G), the most widely used ... well-established brain tumor mouse model, KX2-361 consistently clears brain ...
(Date:12/24/2014)... FLINT, Mich. , Dec. 24, 2014  Diplomat ... largest independent specialty pharmacy, is proud to announce ... and quality at Diplomat, will take office as the ... 2015. The formal induction ceremony will take place Feb. ... which will be held at the Renaissance Center in ...
(Date:12/24/2014)... Dec. 23, 2014 Echo Therapeutics, Inc. ... company focused on skin permeation, continuous glucose monitoring ... W. Hollander has been appointed Chief Executive ... more than 20 years of experience in the ... most recently served as Vice President, Business Development, ...
Breaking Medicine Technology:Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3
... 2011 IBM (NYSE: IBM ) and ... NCD Challenge , a competition among a number ... of students to find new ways to address the rise ... (Logo: http://photos.prnewswire.com/prnh/20090416/IBMLOGO ) Illnesses such ...
... bio-pharmaceutical companies lose the ability to communicate externally because ... internal Advocacy groups will become more important to a ... cost effectiveness of care by communicating concepts and arranging ... Since internal Advocacy groups are not known ...
Cached Medicine Technology:IBM Launches University Competition to Combat Growth of Non-Communicable Diseases 2IBM Launches University Competition to Combat Growth of Non-Communicable Diseases 3Pharmaceutical Advocacy Groups Focus on Value-of-Care Initiatives 2
... to its design, this is the ... stone therapy in urinary and biliary ... a multipurpose lithotripter with other applications ... nephrolithotomy. ,The basic system comprises the ...
All the power and performance of the STS - T but now available with a stand-alone 9" II C-Arm...
... Compact Sigma is designed to easily ... precise mechanical coupling eliminates clumsy time ... performed as well. Dorniers patented isocentric ... ,Positioning is simple using the Dornier ...
The latex free, hydrophilic Self-Cath Plus is designed for single use, intermittent self-catheterization. The unique hydrophilic coating activates immediately upon exposure to water for fast, clean...
Medicine Products: