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Biphasic electrical stimulation: A strategy may bring hope to spinal cord injury patients
Date:8/23/2013

Researchers at the Beihang University School of Biological Science and Medical Engineering, led by Dr. Yubo Fan, have discovered that Biphasic Electrical stimulation (BES), a non-chemical procedure, may be used as a strategy for preventing cell apoptosis in stem cell-based transplantation therapy. The article describing their studies will be published in the August 2013 issue of Experimental Biology and Medicine. The scientists believe that their technique will be used for spinal cord injury patients in the future.

Spinal cord injury (SCI) is a serious disease of the central nervous system. According to Spinal Cord Injury Facts & Statistics, 250,000 Americans are spinal cord injured patients. Approximately 52% of spinal cord injured individuals are considered as paraplegic, and 47% patients are quadriplegic. In addition, 11,000 new injuries occur each year, and 82% are male.

Transplantation of Stem Cells is a potential clinical therapy for repair and regeneration of injured spinal cord, and brings new hope for patients. However, the survival rate of transplanted cells is relatively low because the cells are particularly vulnerable to apoptosis in the spinal cord. Factors proposed for causing such low survival include immune reactions, limited trophic factors and hypoxia. It appears that a lack of adequate growth factors plays an important role in the survival of transplanted cells. "We've shown for the very first time that BES may provide insight into preventing growth factor deprivation-triggered apoptosis in olfactory bulb neural precursor cells (OB NPCs)," said Yubo Fan, professor of Biological Science and Medical Engineering at Beihang and senior author. "These findings suggest that BES may thus be used as a strategy to improve cell survival and prevent cell apoptosis in stem cell-based transplantation therapies," Fan explained. The results may guide future efforts to rest
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Contact: Dr. Yubo Fan
yubofan@buaa.edu.cn
Society for Experimental Biology and Medicine
Source:Eurekalert

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