Navigation Links
Biopsies may overlook esophagus disease
Date:9/6/2012

SALT LAKE CITY Sept. 6, 2012 - University of Utah engineers mapped white blood cells called eonsinophils and showed an existing diagnostic method may overlook an elusive digestive disorder that causes swelling in the esophagus and painful swallowing.

By pinpointing the location and density of eosinophils, which regulate allergy mechanisms in the immune system, these researchers suggest the disease eosinophilic esophagitis, or EoE, may be under- or misdiagnosed in patients using the current method, which is to take tissue samples (biopsies) with an endoscope.

These findings are published as the cover article in the September 2012 issue of the Journal of Allergy and Clinical Immunology. Despite the limitations of current detection methods for EoE, the study authors say biopsies remain the current standard of care, but the engineers are working toward new diagnostic methods that could be available in five years.

In EoE, eosinophils typically found in the bloodstream invade the esophagus and start chewing away at its lining. Often triggered by food allergies, EoE symptoms overlap with other disorders such as acid reflux.

"The gold standard for understanding this disease is detecting the location and presence of eosinophils in the esophagus. Unfortunately, eosinophils are not uniformly distributed within the esophagus, which can lead to underdiagnosis," says study co-author Leonard Pease, assistant professor of chemical engineering at the University of Utah. He is also an adjunct professor of gastroenterology and pharmaceutics.

The University of Utah team showed that even a patient with known EoE would require more than 31 random tissue samples, or biopsies, from an area in the esophagus with low eosinophil density to reliably diagnose EoE. Currently, if a patient is suspected of having EoE, five to 12 biopsies are collected along the esophagus using an endoscope. If more than 15 eosinophils turn up in any one of
'/>"/>

Contact: Aditi Risbud
aditi.risbud@coe.utah.edu
213-400-5815
University of Utah
Source:Eurekalert  

0

GOOD

Page: 1 2 3

Related medicine news :

1. 6 month follow-up of patients with benign MRI-guided breast biopsies may not be necessary
2. Patient mental health overlooked by physician when a family member is present
3. Eczema Non-Profit Seeks To Shine New Light On Overlooked Condition
4. Doctors overlook chemical illnesses, study finds
5. New study suggests clinicians overlook alcohol problems if patients are not intoxicated
6. Aspirin protects against Barretts esophagus
7. ASGE initiative examines real-time imaging of Barretts esophagus
8. Witnessing, Experiencing Traumatic Events May Worsen Heart Disease
9. Pulse pressure elevation could presage cerebrovascular disease in Alzheimers patients
10. Mayo Clinic offers newly approved treatment for acid reflux disease
11. Spouses of Cancer Patients May Have Raised Risk of Heart Disease, Stroke
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Biopsies may overlook esophagus disease
(Date:5/18/2013)... (HealthDay News) -- Just a few extra cups of ... an autoimmune liver disease known as primary sclerosing cholangitis ... Mayo Clinic in Rochester, Minn., found that drinking coffee ... disease, which can lead to cirrhosis of the liver, ... not prove a cause-and-effect relationship. "While rare, ...
(Date:5/18/2013)... 18, 2013) There are significant cost and ... to diagnose or treat gastrointestinal problems, according to ... , A study by New York Presbyterian Hospital ... testing may substantially reduce the cost and risk ... is believed to affect nearly 25 percent of ...
(Date:5/18/2013)... ID (PRWEB) May 18, 2013 ... when it comes to safety and comfort of ... requirements and provides clients with an effective and ... This is an integrated, turnkey communications solution ... care, while allowing residents independence and privacy. ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Transvaginal ... products continue to move forward in a consolidated litigation ... Liebhard LLP reports. According to a notice on the ... Ethicon pelvic mesh litigation will be held on Wednesday, ... have been filed in the proceeding on behalf of ...
(Date:5/18/2013)... The “World Healthcare IT Market: Trends & Forecast (2010 ... restraints, and opportunities in North America, Europe, Asia, & ... 89 market data tables , ... , http://www.marketsandmarkets.com/Market-Reports/healthcare-information-technology-market-136.html , Early buyers ... healthcare IT market is expected to grow from $99.6 ...
Breaking Medicine News(10 mins):Health News:Study Links Coffee to Lower Risk for Rare Liver Disease 2Health News:New research identifies practice changes to improve value and quality of GI procedures 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 2Health News:VisionLink Nurse Call System's New Features Serve the Unique Needs of Retirement Communities 3Health News:Transvaginal Mesh Lawsuits: Bernstein Liebhard LLP Notes Upcoming Case Management Conference in New Jersey Ethicon Pelvic Mesh Litigation 2Health News:Transvaginal Mesh Lawsuits: Bernstein Liebhard LLP Notes Upcoming Case Management Conference in New Jersey Ethicon Pelvic Mesh Litigation 3Health News:Healthcare IT Market to reach US$ 162.2 Billion by 2015 at a CAGR of 10.2% - New Report by MarketandMarkets 2Health News:Healthcare IT Market to reach US$ 162.2 Billion by 2015 at a CAGR of 10.2% - New Report by MarketandMarkets 3
... Inc., a global provider of image management services ... announced that it has made a contribution to ... Vascular Association (AVA). Open the Pathway is an ... M2S has a long-term commitment to vascular treatment ...
... legislators announced a budget deal that includes temporary revenues in ... them permanent, SEIU members and community allies from around the ... in Sacramento and the Governor,s offices in Los Angeles, Riverside, ... week.The rallies are an effort to stop the bad budget ...
... incentivesPORTLAND, Ore., Feb. 11 Regence BlueCross BlueShield of ... the Boys and Girls Clubs of Central Oregon. The ... develop healthy habits and decision making skills, and improve ... impact that our choices have on health, and we,re ...
... better diagnosis, treatment for heart patients , , WEDNESDAY, Feb. ... contrast echocardiography had a significant impact on the diagnosis ... new study found. , Echocardiography bounces sound waves into ... moving heart. If that image isn,t clear enough, it ...
... Program Teaches Earth-Friendly Health ChoicesMIDLAND, Mich., Feb. 11 ... looking for ways to go green. By implementing ... program ( www.HealthEnhancementSystems.com ), Green ... www.greenplanetwellness.com/?from=nw_021109 ), participants learn small steps ...
... Calif., Feb. 11 Valeant Pharmaceuticals International (NYSE: ... a conference call on Tuesday, February 24, 2009 at ... for the 2008 fourth quarter and year.The dial-in number ... code 83660030. International callers should dial ...
Cached Medicine News:Health News:M2S, Inc. Makes Contribution to American Vascular Association 2Health News:M2S, Inc. Makes Contribution to American Vascular Association 3Health News:Boys and Girls Clubs of Central Oregon Get $10K Regence Grant 2Health News:Study Brings Value of Echocardiography Into Focus 2Health News:Green Planet Wellness Helps Employers Have Big Environmental Impact 2Health News:Valeant Pharmaceuticals to Announce 2008 Fourth Quarter and Year Results on February 24, 2009 2
(Date:5/17/2013)... , May 17, 2013  Orexigen® Therapeutics, Inc. (Nasdaq: ... a company overview at the UBS Global Healthcare Conference in ... for Wednesday, May 22 nd at 11 a.m. Eastern ... of the presentation, please visit the Investor Relations section of ... will be available for 14 days after the event. ...
(Date:5/17/2013)... /PRNewswire-iReach/ -- United Medical Education, a company that provides ... Advanced Life Support (PALS) and Basic Life Support (BLS), ... online course manuals. In order to gain access ... an account with the company. By offering the free ... Education is setting a precedent among similar companies. ...
(Date:5/17/2013)... , May 17, 2013  Serving a region of ... Rico , Caribbean Imaging and Radiation Therapy (CIRT, ... therapy capabilities with the acquisition of an Elekta Versa HD™ ... Versa HD offers clinicians the versatility to deliver conventional therapies ... while also enabling treatment of highly complex cancers that require ...
Breaking Medicine Technology:ACLS Online Course Manuals are Now Available at No Cost through United Medical Education 2Puerto Rico's Caribbean Imaging and Radiation Therapy Center Orders Elekta's New Versa HD System for Treatment of Cancer Patients 2
... a First, Immunotherapy Works Against Neuroblastoma-- PHILADELPHIA, May 28 ... for an experimental therapy using elements of the body,s ... neuroblastoma, a challenging cancer of the nervous system.John M. ... of Philadelphia, co-authored the phase 3 clinical trial, which ...
... Survival, Disease Control and Neurotoxicity Data To Be ... Support Picoplatin as a Neuropathy-Sparing Alternative to Oxaliplatin ... Management Team to Host Analyst and Investor Briefing ... SOUTH SAN FRANCISCO, Calif., May 28 Poniard ...
Cached Medicine Technology:New Therapy Enlists Immune System to Boost Cure Rate in a Childhood Cancer 2New Therapy Enlists Immune System to Boost Cure Rate in a Childhood Cancer 3Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer 2Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer 3Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer 4Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer 5Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer 6
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: