Navigation Links
Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer
Date:8/4/2009

st common adverse events associated with Bezielle were grade 1 and 2 gastrointestinal side effects, accounting for 56% of all drug-related adverse events.

Efficacy Analysis

Sixteen of the twenty-seven participants in the Phase 1B clinical trial were evaluable according to the Response Evaluation Criteria in Solid Tumors (RECIST). Of these sixteen evaluable women, five (31%) were stable on Bezielle for greater than 90 days and two (13%) were stable on Bezielle for greater than 180 days. Three patients (19%) on Bezielle had objective tumor regression, as evaluated by an independent radiology review.

Four patients discontinued from the study with stable disease, and of these four patients, one patient had objective tumor regression during 449 days of Bezielle treatment and continues to be stable off of study medication for a total of 600 days. A second patient who discontinued Bezielle treatment with stable disease continues to be stable for 832 days and has not started any new anticancer treatment. A third patient who discontinued with stable disease was stable for 591 days before evidence of progression. Further analyses on overall survival and progression-free survival will be performed.

Dose Escalation and Compliance

Overall compliance with study medication was excellent with 90% of prescribed doses taken. A maximum tolerated dose, as defined in study protocol, was never established despite dose escalation reaching a dose that was four times (40g/day) the previously evaluated Phase 1A dose.

"We are eager to advance Bezielle to Phase 2 clinical testing as the drug continues to have an improved safety profile over currently available chemotherapeutic agents, and shows encouraging clinical activity in a cohort of women who have been heavily pretreated for metastatic breast cancer," said Dr. Mary Tagliaferri, President and Chief Medical Officer, Bionovo.

<
'/>"/>
SOURCE Bionovo, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine news :

1. Bionovo Announces Closing of Public Offering of Common Stock
2. Bionovo Describes a New Class of Therapeutic Compounds
3. Bionovo Announces 2007 Financial Results and Highlights
4. Bionovo to Present at the Cambria Capital Investor Meeting
5. John D. Baxter, M.D. Joins Bionovos Board of Directors
6. Bionovo to Present at the Rodman & Renshaw 10th Annual Global Investment Conference
7. Bionovo to Present Recent Findings of BN108, its Anticancer Agent, at the 31st Annual San Antonio Breast Cancer Symposium
8. Willa A. Hsueh, M.D., Joins Bionovos Scientific Advisory Board
9. Bionovo Announces Cost Control Measures Taken
10. Bionovo Announces Presentation at the National Cancer Institute
11. Jan Ake Gustafsson, M.D., Ph.D., Joins Bionovos Scientific Advisory Board
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... July 29, 2014 Winter is here ... Thursday afternoon in Sydney’s central business district. That is, ... Maori costume transformed the otherwise ordinary day into a ... singers are ardent advocates of The Truth About Drugs, ... of Scientology . They woke up the city with ...
(Date:7/29/2014)... Daily Gossip writes in its Fibroids Miracle review that ... teach users how to permanently eliminate uterine fibroids. The system ... over the world. , They have been able to ... quickly as 12 hours. This means that pain and other ... The Fibroids Miracle review also indicates that the method was ...
(Date:7/29/2014)... 29, 2014 Daily Gossip indicates in its ... tips to gain beautiful and clear skin in just 30 ... see these positive results even sooner than that. The new ... who used this step by step program, too. , ... for years. Mike battled this condition for a decade and ...
(Date:7/29/2014)... procedures using stem cells are running far ahead of ... a review in the August issue of ... journal of the American Society of Plastic Surgeons ... the marketplace is saturated with unsubstantiated and sometimes fraudulent ... Michael T. Longaker of Stanford University Medical Center and ...
(Date:7/29/2014)... 2014 As the Ebola outbreak in Liberia ... to both purchase critical emergency supplies locally, as well as ... These supplies will contain materials used to control the spread ... areas of the country. , With a large programmatic ... to the Ebola outbreak in the region. The current epidemic ...
Breaking Medicine News(10 mins):Health News:Sydney Business District “Rocked” by The Truth About Drugs 2Health News:Amanda Leto’s Fibroids Miracle Review Reveals Clinically Proven Uterine Fibroids Cure System 2Health News:Acne No More Review Reveals Most Effective Acne Cure Program 2Health News:Beware of claims about cosmetic stem cells procedures, says review in Plastic and Reconstructive Surgery 2Health News:PCI Responds to Ebola Outbreak in Liberia with Supplies, Awareness Campaigns 2Health News:PCI Responds to Ebola Outbreak in Liberia with Supplies, Awareness Campaigns 3
... Smart for Life(TM), the all-natural weight management program, opened in ... The Raimondo family began their weight-loss journey on the Smart ... of 235 lbs. for 6 family members. As friends and ... Raimondo envisioned an exciting business opportunity. , "Smart ...
... Haemonetics Corporation (NYSE: HAE ) will announce its ... release and 10:00 am (EST) webcast. , Webcast Link: ... from November 2, 2009 after 1:00 pm to November 9, ... Julie Fallon, Tel. (781) 356-9517, ...
... (Nasdaq: JMBA ) - As a part of their ... will be bringing some unexpected feel good boosts into people,s ... and Golden State visitors to free cable car rides this ... Jambassador, will bring unexpected cheer to riders as he makes ...
... ... ... has recently been promoted to Senior Vice President of Operations at Jackson & Coker ... , , , , ,"This position has been vacant for a while and ...
... ... announced the launch of their "Tats for Tatas" fundraising campaign that will ... In the company,s concerted efforts to raise awareness and funds for ... In addition, the company will be donating 10% of all proceeds from ...
... ... book Knockout: Interviews with Doctors Who are Curing Cancer and How to Prevent Getting It ... ... eight medical doctors featured in Suzanne Somers’ new book Knockout: Interviews with Doctors Who are ...
Cached Medicine News:Health News:Smart for Life(TM) Center Opens in Ottawa 2Health News:Surprise! Jamba Juice Treats Lucky San Francisco Cable Car Passengers to Free Rides on Saturday, October 17 2Health News:Surprise! Jamba Juice Treats Lucky San Francisco Cable Car Passengers to Free Rides on Saturday, October 17 3Health News:Jackson & Coker Promotes Tony Rico to Senior VP of Operations 2Health News:Atomic Tattoos Announces "Tats for Tatas" October Fundraising Event to Benefit Local Breast Cancer Research 2Health News:Suzanne Somers Highlights Dr. Stephen Sinatra in Chapter for New Cancer Book 2
(Date:7/29/2014)... 29, 2014  EnteroMedics Inc. (NASDAQ: ETRM ... to treat obesity, metabolic diseases and other gastrointestinal disorders, ... on Thursday, August 7, 2014 at 11:00 AM Eastern ... ended June 30, 2014 and to provide a business ... second quarter conference call may be accessed by dialing ...
(Date:7/29/2014)... -- Synthetic Biologics, Inc. (NYSE MKT: SYN), a developer of ... that cause serious infections and diseases, announced today that ... Company,s stock, the NYSE MKT (the "Exchange") has contacted ... Company stated that its policy is not to comment ... Inc. Synthetic Biologics, Inc. (NYSE MKT: SYN) ...
(Date:7/29/2014)... -- ISPE—the International Society for Pharmaceutical Engineering announced ... as President and CEO, succeeding Nancy Berg ... last fall.  Mr. Bournas takes the helm at ... industry as well as significant international experience.  He ... the expansion of its global initiatives and business ...
Breaking Medicine Technology:EnteroMedics to Host Second Quarter 2014 Financial Results and Business Update Conference Call 2EnteroMedics to Host Second Quarter 2014 Financial Results and Business Update Conference Call 3Synthetic Biologics, Inc. States that Its Policy is Not to Comment on Unusual Market Activity 2ISPE Hires Healthcare Association Exec as CEO 2ISPE Hires Healthcare Association Exec as CEO 3
... The MicroTouch LP (low profile) is ... with a fixed fluoroscopy/x-ray gantry. The MicroTouch ... opposite the gantry and allows the user ... fluoroscopy ,and x-ray without loss of ...
Floor stand stabilizer system...
The robust, easy to maneuver floor-mounted stepper/stabilizer, offers strength and stability that has made this unit one of the most widely accepted floor fixation devices in the industry....
... of a welded titanium capsule containing either ... beads. The capsule body also contains ... x-ray markers to identify the source location ... non-sterile when shipped and must be sterilized ...
Medicine Products: