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Bionovo Describes a New Class of Therapeutic Compounds
Date:11/29/2007

els. Bionovo is taking advantage of the differential effects caused by the two estrogen receptors on cancer formation by developing selective estrogen receptor beta drugs. The mechanism of action of MF101 as a selective estrogen receptor beta therapy may provide a safer, long-term alternative to treat menopausal symptoms.

"Our study findings show a pure chemical compound from MF101 that is selective to the estrogen receptor beta which could lead to multiple novel therapies for the treatment of common conditions such as menopausal hot flashes, vaginal dryness and osteoporosis," said Dale Leitman, M.D., Ph.D., Center for Reproductive Sciences, University of California, San Francisco, principal investigator of the study and member of Bionovo's Scientific Advisory Board. "Unlike any of the drugs we currently prescribe to women, MF101 and liquiritigenin are highly selective to the estrogen receptor beta, and from a mechanistic standpoint, they could be safer drugs to treat many symptoms of menopause."

"We are very pleased to have advanced our ability to characterize MF101 by isolating this chemical compound and this new discovery will significantly strengthen our intellectual property position for our lead compound," added Isaac Cohen, chairman and CEO of Bionovo. "Given the increasing population of women entering menopause, and the lack of safe and effective treatments for these women, we are excited to be on the forefront of developing more selective and safer alternative drugs for this enormous indication."

About MF101

MF101 is an oral drug designed for the treatment of hot flashes and night sweats in peri-menopausal and menopausal women. MF101 is a novel estrogen receptor beta selective agonist and unlike currently available hormone therapies, does not activate the estrogen receptor alpha, known to be implicated in tumor formation. Two hundred and seventeen women were enrolled into a double-blind, placebo-controlled, randomized Phase 2 cli
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SOURCE Bionovo, Inc.
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