Navigation Links
Bionovo Describes a New Class of Therapeutic Compounds
Date:11/29/2007

- Highly selective estrogen receptor beta agonists have promise for safer

therapies in women's health -

EMERYVILLE, Calif., Nov. 29 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI) announced today the publication of a groundbreaking paper in the journal Molecular and Cellular Endocrinology covering the isolation, identification and description of a pure chemical compound, liquiritigenin, which represents a new class of therapeutic compounds showing promise for the safe treatment of menopausal symptoms. Liquiritigenin is an active ingredient in Bionovo's drug candidate, MF101, which just successfully completed a Phase 2 study, and is now being prepared for pivotal Phase 3 testing.

The paper, entitled "Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist" provides details of the selective transcriptional activation of liquiritigenin to the estrogen receptor beta, highlights the advantages of an estrogen receptor beta targeted drug and discusses the isolation and structural identification of the pure chemical compound from Bionovo's MF101.

In brief, the currently available estrogen therapies used to treat menopausal symptoms are non-selective to both of the two known estrogen receptors, alpha and beta. Because of this non-selectivity, all estrogens marketed to treat menopausal symptoms have the potential to cause elevated risks for breast and uterine cancers due to the proliferative effects on breast and uterine tissues mediated through the estrogen receptor alpha. Selective activation of the estrogen receptor beta, however, does not lead to proliferation of MCF-7 breast cancer cell lines or an increase for uterine cancer in mouse xenograph mod
'/>"/>

SOURCE Bionovo, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Bionovo Announces Closing of Public Offering of Common Stock
2. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
3. Study Describes Molecules That Control Blood Pressure
4. Kingfisher Healthcare (KFH) Achieves World Class Quality Platform
5. ADDA Kicks Off AD/HD Awareness Campaign with Four Regional Conferences Beginning Sept. 29 and Series of Fall Teleclasses
6. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
7. First Circuit Court of Appeals Rules Against Philip Morris in Lights Class Action
8. Theater Classes Help Docs Bedside Manners
9. Tarpinian: Misclassification is Theft
10. New class of RNA molecules may be important in human cancer
11. Instrumentation Laboratory Named Top of Class by Respiratory Care Managers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... MillionaireCasket.com is a professional supplier of funeral products. According to ... well in the global market. Recently, the company has announced ... a special offer for all the newly released items. ... caskets are made with superb materials. As is commonly noted, ... respect to the departed saint. MillionaireCasket.com is always here to ...
(Date:7/13/2014)... 13, 2014 Intraocular Lens (IOL) Market: ... 2013 - 2019 , Intraocular lens (IOL) is inserted ... or cataracts. The lenses are inserted inside the eye, ... intraocular lens replaces the focusing power of natural lens. ... lens to deliver the light focusing function which was ...
(Date:7/13/2014)... Victorian Hotel has recently announced that ... of bikes for its "Cycle the City" program, which ... tour the area using a rental bicycle, available for ... to call Vancouver home, as it is a city ... picturesque journeys through the countryside. Vancouver hotel rooms often ...
(Date:7/13/2014)... additives are chemicals, which are added to various fuels ... on, in order to enhance their performance. Fuel additives ... by fuels and improving the combustion properties of fuels. ... scale in the long run, but, in the short ... products. , The various fuel additive types include deposit ...
(Date:7/13/2014)... The Pearland, Texas location of The Little Gym, a ... to 12 years of age that offers everything from gymnastics, ... Summer Camps, is now under new ownership. , Kevin Berry ... spending over six years at The Little Gym of Bellaire ... Berry has over ten years of experience working with children, ...
Breaking Medicine News(10 mins):Health News:Brand New Cherry Caskets Unveiled By China Casket Supplier MillionaireCasket.com 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 2Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 3Health News:Intraocular Lens (IOL) Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2013 - 2019 4Health News:Victorian Hotel Creates Excitement by Adding "Cycle the City" Bike Rentals for Its Vancouver Hotel Rooms 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:The Little Gym of Pearland, TX Now Under New Ownership and Management 2
... ... leads through your website. , ... (PRWEB) November 24, 2009 -- 2009 has been another tough year for the U.S. economy. ... afloat and reduce costs. Typically the first items on the chopping block are things like ...
... , 2009 Q3 Financials, S-1 Registration Statement being Prepared ... WESTON, Fla., Nov. 24 American Scientific Resources Inc. (Pink Sheets: ... update. , Since filing 2007 and 2008 audited financials on Pinksheets ... all part of a long term business plan for the Company. ...
... study finds , TUESDAY, Nov. 24 (HealthDay News) -- ... are at increased risk for asthma, researchers say. , ... an immune response in humans -- is found in ... found persistent wheezing (an early warning sign of asthma ...
... Jamba, Inc. (Nasdaq: JMBA ) announced today the ... Juice(TM) Smoothie and Ice Pop Maker, a Jamba Juice-branded toy ... Created together with Think Wow Toys, the EZ-2 MAKE! ... at a leading toy retailer, starting mid-November. The toy ...
... ... and keep an ongoing dialogue with patients. Through Facebook, Twitter, and other social media outlets, ... answer any questions that patients may have. , ... Atlanta, GA (Vocus) November 24, 2009 -- A plastic surgeon in ...
... ... Monthly Revenue for Central Stations and Security Dealers. , ... Dallas, Texas (PRWEB) November 24, 2009 -- NCL ... Revenue for Central Stations and Security Dealers., , ,"Integrated security systems has been and ...
Cached Medicine News:Health News:We Do Web Content Offers Free Lead Generation Report 2Health News:We Do Web Content Offers Free Lead Generation Report 3Health News:American Scientific Resources Inc. Issues Corporate Update 2Health News:American Scientific Resources Inc. Issues Corporate Update 3Health News:Traffic, Dust Linked to Asthma in Kids 2Health News:Jamba Juice and Think Wow Toys Bring the Smoothie Experience Home With Debut of Jamba Branded Toy Blender 2Health News:Jamba Juice and Think Wow Toys Bring the Smoothie Experience Home With Debut of Jamba Branded Toy Blender 3Health News:Atlanta Plastic Surgeon Using Social Media To Connect with Patients 2Health News:Atlanta Plastic Surgeon Using Social Media To Connect with Patients 3Health News:NCL Security Launches EyeCentral Video Platform for the Security Industry to Generate Recurring Monthly Revenue for Central Stations and Security Dealers 2
(Date:7/10/2014)... 2014  Decision Resources Group finds that while ... specialists are willing to prescribe Durata,s Dalvance (dalbavancin) ... as OPAT, approximately two-thirds of the respondents reported ... hospital inpatients. However, our findings indicate that nearly ... on OPAT following hospital discharge, and most are ...
(Date:1/15/2014)... MILTON, N.Y. , Jan. 15, 2014 Sono-Tek Corporation ... three months ended November 30, 2013, compared to sales of ... or 20%. Once again, this quarter has also shown growth ... in the first quarter of this fiscal year. Markets that ...
(Date:1/15/2014)... , Jan. 15, 2014 As health officials across the ... select Meijer pharmacies in Michigan will ... eligible patients, enabling Meijer pharmacists to administer tests and, in ... by a physician participating in the study. The ...
Breaking Medicine Technology:Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 2Meijer Pharmacy Offers Free Flu, Strep Testing as Influenza Cases Rise Across the Midwest 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: