Navigation Links
Bionovo Describes a New Class of Therapeutic Compounds
Date:11/29/2007

- Highly selective estrogen receptor beta agonists have promise for safer

therapies in women's health -

EMERYVILLE, Calif., Nov. 29 /PRNewswire-FirstCall/ -- Bionovo, Inc. (Nasdaq: BNVI) announced today the publication of a groundbreaking paper in the journal Molecular and Cellular Endocrinology covering the isolation, identification and description of a pure chemical compound, liquiritigenin, which represents a new class of therapeutic compounds showing promise for the safe treatment of menopausal symptoms. Liquiritigenin is an active ingredient in Bionovo's drug candidate, MF101, which just successfully completed a Phase 2 study, and is now being prepared for pivotal Phase 3 testing.

The paper, entitled "Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist" provides details of the selective transcriptional activation of liquiritigenin to the estrogen receptor beta, highlights the advantages of an estrogen receptor beta targeted drug and discusses the isolation and structural identification of the pure chemical compound from Bionovo's MF101.

In brief, the currently available estrogen therapies used to treat menopausal symptoms are non-selective to both of the two known estrogen receptors, alpha and beta. Because of this non-selectivity, all estrogens marketed to treat menopausal symptoms have the potential to cause elevated risks for breast and uterine cancers due to the proliferative effects on breast and uterine tissues mediated through the estrogen receptor alpha. Selective activation of the estrogen receptor beta, however, does not lead to proliferation of MCF-7 breast cancer cell lines or an increase for uterine cancer in mouse xenograph models. Bionovo is taking advantage of the differential effects caused by the two estrogen receptors on cancer formation by developing selective estrogen receptor beta drugs. The mechanism of action of MF101 as a selective estrogen receptor beta therapy may provide a safer, long-term alternative to treat menopausal symptoms.

"Our study findings show a pure chemical compound from MF101 that is selective to the estrogen receptor beta which could lead to multiple novel therapies for the treatment of common conditions such as menopausal hot flashes, vaginal dryness and osteoporosis," said Dale Leitman, M.D., Ph.D., Center for Reproductive Sciences, University of California, San Francisco, principal investigator of the study and member of Bionovo's Scientific Advisory Board. "Unlike any of the drugs we currently prescribe to women, MF101 and liquiritigenin are highly selective to the estrogen receptor beta, and from a mechanistic standpoint, they could be safer drugs to treat many symptoms of menopause."

"We are very pleased to have advanced our ability to characterize MF101 by isolating this chemical compound and this new discovery will significantly strengthen our intellectual property position for our lead compound," added Isaac Cohen, chairman and CEO of Bionovo. "Given the increasing population of women entering menopause, and the lack of safe and effective treatments for these women, we are excited to be on the forefront of developing more selective and safer alternative drugs for this enormous indication."

About MF101

MF101 is an oral drug designed for the treatment of hot flashes and night sweats in peri-menopausal and menopausal women. MF101 is a novel estrogen receptor beta selective agonist and unlike currently available hormone therapies, does not activate the estrogen receptor alpha, known to be implicated in tumor formation. Two hundred and seventeen women were enrolled into a double-blind, placebo-controlled, randomized Phase 2 clinical trial under the directorship of Dr. Deborah Grady in early 2007. Trial results showed that MF101 10 grams/day was statistically superior to placebo at reducing hot flashes and was extremely well tolerated with no serious side effects.

Bionovo, Inc.

Bionovo is a pharmaceutical company focused on the discovery and development of safe and effective treatments for women's health and cancer, markets with significant unmet needs and billions in potential annual revenue. The company applies its expertise in the biology of menopause and cancer to design new drugs derived from botanical sources which have novel mechanisms of action. Based on the results of early and mid-stage clinical trials, Bionovo believes they have discovered new classes of drug candidates within their rich pipeline with the potential to be leaders in their markets. Bionovo is headquartered in Emeryville, California and is traded on the NASDAQ Capital Market under the symbol, "BNVI". For more information about Bionovo and its programs, visit: http://www.bionovo.com.

Forward Looking Statements

This release contains certain forward-looking statements relating to the business of Bionovo, Inc. that can be identified by the use of forward-looking terminology such as "believes," "expects," or similar expressions. Such forward-looking statements involve known and unknown risks and uncertainties, including uncertainties relating to product development, efficacy and safety, regulatory actions or delays, the ability to obtain or maintain patent or other proprietary intellectual property protection, market acceptance, physician acceptance, third party reimbursement, future capital requirements, competition in general and other factors that may cause actual results to be materially different from those described herein as anticipated, believed, estimated or expected. Certain of these risks and uncertainties are or will be described in greater detail in our filings with the Securities and Exchange Commission, which are available at http://www.sec.gov. Bionovo, Inc. is under no obligation (and expressly disclaims any such obligation) to update or alter its forward-looking statements whether as a result of new information, future events or otherwise.

University of California, San Francisco Disclaimer

The information stated above was prepared by Bionovo, Inc. to report the outcome of research conducted on its product and reflects solely the opinion of Bionovo, Inc. Nothing in this statement shall be construed to imply any support or endorsement of Bionovo, Inc. or any of its products, by The Regents of the University of California, its officers, agents and employees.

Dale Leitman, M.D., Ph.D. of the University of California, San Francisco Center for Reproductive Sciences is a scientific advisory board member for Bionovo, Inc. Dr. Leitman does not receive any cash or stock options as compensation for his participation on Bionovo Inc.'s scientific advisory board.


'/>"/>
SOURCE Bionovo, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Related medicine news :

1. Bionovo Announces Closing of Public Offering of Common Stock
2. 454 Sequencing(TM): Science Paper Describes a Novel, Highly Efficient Method of Sequencing Ancient DNA; Sequences the Mitochondria of 10 Individual Mammoths to Prove It
3. Study Describes Molecules That Control Blood Pressure
4. Kingfisher Healthcare (KFH) Achieves World Class Quality Platform
5. ADDA Kicks Off AD/HD Awareness Campaign with Four Regional Conferences Beginning Sept. 29 and Series of Fall Teleclasses
6. A classic method for modeling skin cancer is featured in Cold Spring Harbor Protocols
7. First Circuit Court of Appeals Rules Against Philip Morris in Lights Class Action
8. Theater Classes Help Docs Bedside Manners
9. Tarpinian: Misclassification is Theft
10. New class of RNA molecules may be important in human cancer
11. Instrumentation Laboratory Named Top of Class by Respiratory Care Managers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... Thank you ... Diego on February 8-10. , This event was exclusive to providers and offered ... , The meeting took place at the Manchester Grand Hyatt where attendees gathered for ...
(Date:3/28/2017)... ... ... probably not the first ingredients that come to mind when thinking about healthy food. But ... actually improve health outcomes. And the good news is they may be hiding in some ... paper led by Maria Marco, Ph.D. , University of California, Davis and ...
(Date:3/27/2017)... ... March 27, 2017 , ... ... custom smile makeovers without requiring a referral. Trimble Dental offers a ... treatment, cosmetic dentistry and dental implants. Whether patients have discolored, crooked or missing ...
(Date:3/27/2017)... PA and London UK (PRWEB) , ... March ... ... the speed, agility and ability to gain site attention and engagement over the ... DrugDev educational webinar will discuss how partnering with the right ...
(Date:3/27/2017)... , ... March 27, 2017 , ... ... today announced it will co-exhibit with technology partners LG Business Solutions at ... Marriott Metro Center in Washington D.C., will provide education and examination into the ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... Summary This report provides all the ... interests and activities since 2010. Description The Partnering Deals ... the partnering activity of one of the world,s leading life ... upon purchase to ensure inclusion of the most up to ... be delivered in PDF format within 1 working day of ...
(Date:3/27/2017)... , March 27, 2017  A recent study ... only four freestanding hospitals in the country dedicated to ... and reconstructive surgery, concluded that the Surfacide Helios ® ... integral component in reducing bacterial pathogens not killed by ... were published at the American Burn Association,s 49th Annual ...
(Date:3/27/2017)... , March 27, 2017 LightIntegra Technology ... appointed William "Bill" Dubiel as President and Chief Executive ... elected to the Board of Directors of LightIntegra. ... Executive Chairman of LightIntegra. "This is ... President and Chief Executive Officer. We,ve selected a very ...
Breaking Medicine Technology: