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Bioniche Updates re: Mycobacterial Cell Wall Technology Platform
Date:5/12/2008

- Refractory trial in bladder cancer exceeds 2/3rds enrolment level -

- Presentations re: pre-clinical work in peritoneal cancers -

BELLEVILLE, ON, May 12 /PRNewswire-FirstCall/ - Bioniche Life Sciences Inc. (TSX: BNC), a research-based, technology-driven Canadian biopharmaceutical company, is pleased to provide an update on the clinical and non-clinical development of its proprietary platform technology: Mycobacterial Cell Wall-DNA Complex (MCC).

Phase III Clinical Program in Bladder Cancer

More than two-thirds of the 105 patients required for the Company's first Phase III clinical trial with MCC (trademarked Urocidin) have now been enrolled. The Company expects patient enrolment to be completed in the second half of calendar 2008. The North American trial involves patients with non muscle-invasive bladder cancer that is refractory (unresponsive) to bacillus Calmette-Guerin (BCG) therapy. BCG, the standard of care for non muscle-invasive bladder cancer, has limited efficacy, especially as second-line therapy. It is associated with a number of treatment-limiting side effects that include the potential for both local (bladder) and systemic mycobacterial infections.

The Data Safety Monitoring Committee held its fourth scheduled meeting regarding this clinical trial on May 8, 2008. The role of this independent body is to confirm that the safety of enrolled patients is being appropriately addressed and that, from an efficacy point of view, there is an appropriate basis for continuing the trial. After its meeting, the Committee has recommended that Bioniche "continue the trial unmodified until the next scheduled or triggered meeting". The next scheduled meeting of the Committee will be held in three months.

A number of additional investigational sites have been added to the trial. These are: Towson, Maryland; Dallas, Texas; Poughkeepsie, New York; Evansville, Indiana; Pittsburgh, Pennsylvania; La Mesa, California; and Gar
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SOURCE Bioniche Life Sciences Inc.
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