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Bioniche Represented at House of Commons Sub-Committee on Food Safety
Date:5/28/2009

ing to the intestines of vaccinated cattle, thereby reducing their reproduction within the animal, and reducing the amount of bacteria that can be released through cattle manure in the environment. More than 30,000 cattle have been involved in clinical testing of the vaccine over the past six years.

Several articles have been published in peer-reviewed journals about Econiche. Two articles were published in the Journal of Food Protection in November, 2007 related to field challenge studies conducted at the University of Nebraska-Lincoln involving close to 900 animals in 2002 and 2003. Among the findings by researchers Dr. David Smith and Dr. Rod Moxley et al: Vaccinating a majority of cattle within a pen resulted in a significant protective effect to unvaccinated cattle in the same pen. This effect is called "herd immunity". Another article was published in the Vol. 5, Number 5, 2008 issue of Foodborne Pathogens and Disease outlining the outcome of a clinical vaccine trial of commercially fed cattle that tested the effect of a two-dose regimen of Econiche against type III secreted proteins of enterohemorrhagic Escherichia coli (E. coli) O157:H7 on the probability of detecting the organism on environmental sampling devices. A fourth article appeared in Volume 6, Number 2, 2009 of the Journal of Food Protection (March, 2009) summarizing the results of a large-scale commercial beef feedlot study with Econiche, whereby researchers a David R. Smith, Rodney A. Moxley et al concluded that a two-dose vaccine regimen effectively reduced the probability for E. coli O157:H7 colonization of the terminal rectal mucosa (TRM) of commercially fed cattle at harvest. In this study, vaccinated cattle were 92% less likely to be colonized with E. coli O157:H7 than non-vaccinated cattle. This was the second published study demonstrating more than 90% effectiveness of the Bioniche vaccine against colonization.

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