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Bioniche Presents E. coli O157:H7 Vaccine Data to World Buiatrics Congress in Budapest, Hungary
Date:7/10/2008

ere less likely to be colonized by the bacteria in the mucosa of the terminal rectum at harvest (OR=0.014, p<0.0001), resulting in a vaccine colonization efficacy of 98.3%. A two-dose vaccination was used to evaluate hide contamination in the feedlot. Hides were sampled for E. coli O157:H7 contamination twice in the feedlot and immediately before and after animals were shipped to the abattoir. This same study also found a statistically significant reduction in the likelihood of vaccinated animals having contaminated hides. Additionally, pen-level prevalence following a two dose vaccination was assessed in a feedlot study. Vaccinated pens were less likely than unvaccinated pens to test positive (OR=0.59, p<0.004) using the ROPES method.

"These results provide compelling evidence that vaccination of cattle with the Bioniche E. coli O157:H7 cattle vaccine has the potential to be an effective pre-slaughter intervention for the reduction of E. coli O157:H7 shedding, colonization, hide contamination, and pen-level prevalence," concluded Dr. Rogan.

Food recalls due to E. coli O157:H7 contamination continue to be a concern in beef, produce and prepared food. On-farm interventions to reduce the shedding of E. coli O157:H7 by cattle, such as vaccination, may assist in reducing the potential for food and water contamination and the resulting human illnesses and deaths.

Approximately 100,000 cases of human infection with the E. coli O157:H7 organism are reported each year in North America. 2% to 7% of those people develop hemolytic uremic syndrome (HUS), a disease characterized by kidney failure (in recent outbreaks, this percentage has risen to as high as 16%). Five percent of HUS patients die, many of them children and senior citizens, whose kidneys are more sensitive to damage.

In addition to being infected by contaminated food or water, individuals can become infected from E. coli O157:H7 by visiting animal exhibits. Petting zoos, fairs, and agri
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SOURCE Bioniche Life Sciences Inc.
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