Navigation Links
Biomedical Research Centre searches for immunological biomarkers

Persistent inflammation and the activation of the immune system is the key pathological mechanism affecting many long-term conditions, such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease and is the predominant mechanism underlying organ transplant rejection. But the molecular and cellular processes triggering these inflammatory and immune responses remain little understood. A group of London-based researchers hope that by extending understanding of the biological processes, they will be able to identify 'biomarkers' in the tissue and blood, which in future could be used to diagnose these conditions, to predict how they will develop and how an individual will respond to treatment.

The 500,000 research programme is being carried out at National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, working in partnership with King's College Hospital NHS Foundation Trust and Barts and The London School of Medicine and Dentistry

Professor Frank Nestle, Mary Dunhill Chair of Cutaneous Medicine and Immunotherapy at King's College London, explains: "We want to test the theory that there are common immunological pathways underlying many chronic inflammatory diseases and that these could serve as valuable biomarkers for diagnostic, prognostic and therapeutic purposes."

Key to the success of this research programme is the Biomedical Research Centre's immune monitoring core, which consists of cutting-edge high throughput flow cytometric analysis and flow sorting equipment as well as multiplex cytokine analysis equipment. This technology enables researchers to analyse events within particular cell types involved in the body's immune response, such as T cells and dendritic cells, in minute detail with statistical accuracy.

In addition, the Centre's strategic agreement with BD Biosciences, a segment of BD, a leading global medical technology company, enables its investigators to access BD Biosciences' novel flow based technologies, reagents in the development pipeline and to co-develop and commercialise potential immunological biomarkers.

Researchers will use these technologies to study the activities within the cells of healthy volunteers to establish a range of variance in the normal population and develop a potential immunological signature (a combination of immune markers characteristic for a given cell type or its state of activation).

They will then test this signature using tissue and blood samples taken from patients with psoriasis, kidney transplant rejection and rheumatoid arthritis in the first instance to see if it can be accurately used for the early diagnosis of these conditions. Following this, they will undertake a series of prospective studies to test the predictive accuracy of the signatures in relation to disease progression and response to therapies, before studying other conditions, such as ulcerative colitis, Crohn's disease and transplant rejection.

Professor Graham Lord, Deputy Director of the Biomedical Research Centre said: "This research programme is hugely exciting as it brings our patients together with cutting-edge technology, basic science and clinical medicine. By carrying out detailed studies of cell activity, we aim to develop an immunological biomarker set that will transform the way that a number of specific inflammatory conditions are diagnosed and managed in future. Our patients will be the first to benefit from any new discoveries."


Contact: Andrea Ttofa
King's College London

Related medicine news :

1. Nine International Research Teams Collaborate to Successfully Operate Multiple Biomedical Robots from Numerous Locations
2. Sponsor-A-Scientist: New Option to Fund Biomedical Research
3. Biomedical Research Centre developing enhanced cells as therapies
4. Environmental Tectonics Corporations BioMedical Systems Division Announces First BARA-MED(R) Monoplace Hyperbaric Chamber Sale in Romania
5. New test for safer biomedical research results
6. Successful Beginning for Wellstone Muscular Dystrophy Center at Boston Biomedical Research Institute
7. 17 of Americas Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences
8. Response Biomedical Corporation Announces Appointment of Vice President Finance & Administration and Chief Financial Officer
9. Entest BioMedical Inc. Adds Former National Cancer Institute Researcher to Scientific Advisory Board With Focus on Stem Cell Cancer Patient Therapies
10. New Video Series Spotlights Role of Biomedical Engineers in Caring for Total Artificial Heart Patients
11. Response Biomedical Closes $12.65 million Unit Offering
Post Your Comments:
(Date:6/27/2016)... (PRWEB) , ... June 27, ... ... in the patient payment industry today announced its strategic partnership with Connance, ... system workflows. , The two companies’ proven, proprietary technology combine to provide ...
(Date:6/26/2016)... ... 27, 2016 , ... Quality metrics are proliferating in cancer care, and are ... the eye of the beholder, according to experts who offered insights and commentary in ... Managed Care. For the full issue, click here . , For the American ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
(Date:6/23/2016)... -- , , , WHEN: , ... , , , LOCATION: , , , Online, with free ... EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice President ... Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... is witnessing an exceptional era. Several new demand spaces, such as ...
(Date:6/23/2016)... -- The vast majority of dialysis patients currently receive ... usually 3 times a week, with treatment times averaging ... equipment preparation and wait time.  This regimen can be ... who are elderly and frail.  Many elderly dialysis patients ... for some duration of time. Residents in ...
Breaking Medicine Technology: