Navigation Links
Biomedical Research Centre searches for immunological biomarkers

Persistent inflammation and the activation of the immune system is the key pathological mechanism affecting many long-term conditions, such as rheumatoid arthritis, psoriasis, ulcerative colitis, and Crohn's disease and is the predominant mechanism underlying organ transplant rejection. But the molecular and cellular processes triggering these inflammatory and immune responses remain little understood. A group of London-based researchers hope that by extending understanding of the biological processes, they will be able to identify 'biomarkers' in the tissue and blood, which in future could be used to diagnose these conditions, to predict how they will develop and how an individual will respond to treatment.

The 500,000 research programme is being carried out at National Institute for Health Research (NIHR) comprehensive Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust and King's College London, working in partnership with King's College Hospital NHS Foundation Trust and Barts and The London School of Medicine and Dentistry

Professor Frank Nestle, Mary Dunhill Chair of Cutaneous Medicine and Immunotherapy at King's College London, explains: "We want to test the theory that there are common immunological pathways underlying many chronic inflammatory diseases and that these could serve as valuable biomarkers for diagnostic, prognostic and therapeutic purposes."

Key to the success of this research programme is the Biomedical Research Centre's immune monitoring core, which consists of cutting-edge high throughput flow cytometric analysis and flow sorting equipment as well as multiplex cytokine analysis equipment. This technology enables researchers to analyse events within particular cell types involved in the body's immune response, such as T cells and dendritic cells, in minute detail with statistical accuracy.

In addition, the Centre's strategic agreement with BD Biosciences, a segment of BD, a leading global medical technology company, enables its investigators to access BD Biosciences' novel flow based technologies, reagents in the development pipeline and to co-develop and commercialise potential immunological biomarkers.

Researchers will use these technologies to study the activities within the cells of healthy volunteers to establish a range of variance in the normal population and develop a potential immunological signature (a combination of immune markers characteristic for a given cell type or its state of activation).

They will then test this signature using tissue and blood samples taken from patients with psoriasis, kidney transplant rejection and rheumatoid arthritis in the first instance to see if it can be accurately used for the early diagnosis of these conditions. Following this, they will undertake a series of prospective studies to test the predictive accuracy of the signatures in relation to disease progression and response to therapies, before studying other conditions, such as ulcerative colitis, Crohn's disease and transplant rejection.

Professor Graham Lord, Deputy Director of the Biomedical Research Centre said: "This research programme is hugely exciting as it brings our patients together with cutting-edge technology, basic science and clinical medicine. By carrying out detailed studies of cell activity, we aim to develop an immunological biomarker set that will transform the way that a number of specific inflammatory conditions are diagnosed and managed in future. Our patients will be the first to benefit from any new discoveries."


Contact: Andrea Ttofa
King's College London

Related medicine news :

1. Nine International Research Teams Collaborate to Successfully Operate Multiple Biomedical Robots from Numerous Locations
2. Sponsor-A-Scientist: New Option to Fund Biomedical Research
3. Biomedical Research Centre developing enhanced cells as therapies
4. Environmental Tectonics Corporations BioMedical Systems Division Announces First BARA-MED(R) Monoplace Hyperbaric Chamber Sale in Romania
5. New test for safer biomedical research results
6. Successful Beginning for Wellstone Muscular Dystrophy Center at Boston Biomedical Research Institute
7. 17 of Americas Most Promising Scientists Selected as 2009 Pew Scholars in the Biomedical Sciences
8. Response Biomedical Corporation Announces Appointment of Vice President Finance & Administration and Chief Financial Officer
9. Entest BioMedical Inc. Adds Former National Cancer Institute Researcher to Scientific Advisory Board With Focus on Stem Cell Cancer Patient Therapies
10. New Video Series Spotlights Role of Biomedical Engineers in Caring for Total Artificial Heart Patients
11. Response Biomedical Closes $12.65 million Unit Offering
Post Your Comments:
(Date:10/12/2015)... Grove Village, IL, USA (PRWEB) , ... October ... ... solutions and high-fidelity personal audio products, will present the latest version of Companion ... insert earphones for audiometry, at the European Union of Hearing Aid Acousticians’ (EUHA) ...
(Date:10/12/2015)... ... October 12, 2015 , ... FEI Behavioral Health, ... from EAP to crisis management, will present a session at the Wisconsin Society ... 14-16, 2015. , FEI’s Chief Operating Officer Daniel Potterton will present an informative ...
(Date:10/12/2015)... FL (PRWEB) , ... October 12, 2015 , ... ... Awareness Month, IQ Formulations today announced its charitable donation to the National Breast ... inspiring hope in those affected by breast cancer through early detection, education, and ...
(Date:10/12/2015)... ... October 12, 2015 , ... SQM Group is proud ... contact channel benchmarking study. Be a part of this insightful and leading-edge ... customer experience, customer journey, contact channel execution and intelligence, workforce optimization, and tools ...
(Date:10/12/2015)... ... October 12, 2015 , ... Holcomb – Kreithen Plastic ... in Florida, announced today that it will host “Plastic Surgery University,” an educational series ... Town Center (“UTC Mall”) in Sarasota, FL on Saturday, October 24, 2015. , ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... Leadership of the National Association of Vision Care ... Aspasia Shappet , CEO of MESVision resumed her role as ... at its annual strategic planning meeting in Chicago ... the organization from May 2013 to May of this year. ... a result of the increased demands of his recent appointment ...
(Date:10/12/2015)... , Oct. 12, 2015 A new computer ... children can predict whether they will develop effective language ... to a study in the journal Brain and ... --> In the journal,s Oct. 12 online edition, ... computer program determines how specific regions of the brain ...
(Date:10/12/2015)... ) ... "Personalized Medicine, Targeted Therapeutics and Companion Diagnostic ... Industry Trends, Technologies, Participants, and Environment" ... ) has announced the addition of ... Companion Diagnostic Market to 2019 - Strategic ...
Breaking Medicine Technology: