Navigation Links
Biomarkers predict risk for invasive breast cancer years before the tumor develops
Date:11/12/2007

A team of scientists from the University of California San Francisco has identified distinct molecular markers that predict whether or not a woman is likely to develop subsequent invasive cancer after initial diagnosis with a noninvasive form of early breast cancer. The research, published by Cell Press in the November issue of Cancer Cell, provides critical information that can be used to determine whether a woman should receive more or less aggressive therapy.

Approximately 12-15% of women diagnosed with ductal carcinoma in situ (DCIS), a tumor limited to milk ducts, develop a subsequent invasive cancer event within the first decade after surgical lumpectomy. However, due to the absence of reliable predictors to identify those women that will develop future tumors formation, all women diagnosed with DCIS tend to be offered similar treatment options. Identification of biomarkers that predict future tumor development would allow us to stratify a womens individual risk for subsequent invasive tumors and avoid over- and under- treatment, says lead author Dr. Thea D. Tlsty and clinician, Dr. Karla Kerlokowske, both from the Comprehensive Cancer Center at the University of California San Francisco.

Dr. Tlsty, Gauthier and Berman hypothesized that cells capable of activating pathways linked to stress-induced cell death would not form subsequent tumors while cells that bypass stress signals would be more likely to eventually progress to tumor formation. The researchers evaluated molecular characteristics and their association with outcome in a group of women diagnosed with DCIS and found that expression of biomarkers indicative of a short-circuited response to cellular stress predicts DCIS with a worse outcome and is a defining characteristic of an aggressive phenotype called basal-like tumors. Conversely, a disease-free prognosis is associated with an intact response to cellular stress.

Mechanistic studies indicated that deregulation of t
'/>"/>

Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
2. Study makes progress in zoning in on biomarkers for better colon cancer treatment
3. Waist-to-hip ratio may better predict cardiovascular risk than body mass index
4. UCLA researchers identify markers that may predict diabetes in still-healthy people
5. Use of certain lipid measures not more effective in predicting coronary heart disease
6. First biomarker discovered that predicts prostate cancer outcome
7. Brain Lesions Predict MS Progression
8. ZIP codes and property values predict obesity rates
9. Work Time Predicts Sleep Time
10. Thomson Scientific Predicts Nobel Laureates
11. Segal Survey Predicts Declines in Trends for Fifth Consecutive Year
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... Angeles, CA (PRWEB) September 20, 2014 ... score of 3.1 out of 5, indicating a moderately ... firm IBISWorld, this score reflects current and future pricing ... from historically high prices. Other factors that negatively affect ... in demand for construction and the moderate switching costs. ...
(Date:9/20/2014)... California (PRWEB) September 20, 2014 Final ... have announced the release of the Information theme for FCPX ... would use to describe the Information theme,” says Christina Austin, ... easy to look so professional.” , Information features easy to ... the parameters of the environment. Change the background color, color ...
(Date:9/20/2014)... September 20, 2014 MarijuanaDoctors.com recently ... showing at the PAIN Week conference that was ... and Casino in Las Vegas from September 2nd ... attended PAIN Week in the hopes of educating ... viable and legitimate tool to treat chronic Pain, ...
(Date:9/19/2014)... “Copay coupons,” a drug manufacturer marketing ... among patients with prescription drug coverage, may now be ... report from the Department of Health and Human ... laws prohibit suppliers from offering side-payments to increase sales ... , The report highlights that two recent surveys, including ...
(Date:9/19/2014)... Sept. 19, 2014 (HealthDay News) -- As kids transition ... targets of cyberbullies, according to a recent study. ... 5 through 8 found that verbal and physical bullying ... vary, bullying intervention and prevention strategies must address all ... among boys and girls, the researchers said. The study ...
Breaking Medicine News(10 mins):Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 2Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 3Health News:Plumbing Construction Services Procurement Category Market Research Report from IBISWorld Has Been Updated 4Health News:Today Pixel Film Studios Announced the Release of the Information Theme for Final Cut Pro X 2Health News:MarijuanaDoctors.com Experiences Unprecedented Support and Growth at Pain Week 2014 2Health News:PCMA: New OIG Report Cites Drug Manufacturer“Copay Coupon” Use in Medicare Part D 2Health News: Cyberbullying Seems to Ramp Up in Middle School 2
... Safety Initiatives, DUBLIN, Ohio, Dec. 3 ... participating in the Institute for Healthcare,Improvement,s (IHI) 5 ... it is granting $537,000 to 37 hospitals that,enroll ... receive an average of,$15,000 each to help deepen ...
... COMPOUNDERS; ENABLES CONVENIENT, SECURE, VIRTUALLY ... OF CLASS II CONTROLLED SUBSTANCES, LAKE FOREST, ... provider of outsourced hospital compounded sterile preparations,announced a ... entire line of Schedule II Controlled Substances.,The initiative ...
... equipment, survey finds , , MONDAY, Dec. 3 (HealthDay News) -- ... nearest emergency room might want to keep a new finding ... United States have all the equipment they should have on ... to the survey, however, so the UCLA researchers suspect the ...
... income families and,uninsured individuals everywhere now have access ... prescription per month with delivery to their,home or ... new prescription assistance service,to those who qualify. It ... coverage, according to Doug Pierce, founder of the ...
... C-section has hit number one for,inpatient surgery in the ... Scarring, swelling, tenderness and surgical recovery are a,reality for ... Cesarean Underwear(TM) attempts to address the needs,of Cesarean moms ... of a C-section in mind. See http://www.cpanty.com ., ...
... Misys plc (FTSE: MSY.L),the global application software and services ... its Equation and Trade Innovation,solutions to support its expansion ... installed in its Hong Kong location since,2003, and have ... and,business for the bank. UCB concluded to expand the ...
Cached Medicine News:Health News:Cardinal Health Foundation Grants $537,000 to Rural, Public Hospitals in Support of IHI'S 5 Million Lives Campaign 2Health News:Cardinal Health Foundation Grants $537,000 to Rural, Public Hospitals in Support of IHI'S 5 Million Lives Campaign 3Health News:Cardinal Health Foundation Grants $537,000 to Rural, Public Hospitals in Support of IHI'S 5 Million Lives Campaign 4Health News:PharMEDium Announces Electronic 222 Ordering Initiative 2Health News:Most ERs Not Fully Prepared for Pediatric Patients 2Health News:Most ERs Not Fully Prepared for Pediatric Patients 3Health News:$7 Brand Name Prescriptions for Low Income and Un-Insured Avoid Prescription Discount Cards! 2Health News:Finally, Easy After-Cesarean Care for the 1.3 Million C-Section Moms 2Health News:United Commercial Bank Extends its Use of Misys' Equation and Trade Innovation Systems to Support its Expansion in Taiwan 2Health News:United Commercial Bank Extends its Use of Misys' Equation and Trade Innovation Systems to Support its Expansion in Taiwan 3
(Date:9/19/2014)... 19, 2014 Research and Markets has ... Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to ... purposes of this report, the human microbiome market is segmented ... microbiome market is expected to be valued as $294 million ... of 22.3% within the forecast period of 2019-2023. The market ...
(Date:9/19/2014)... Mich. , Sept. 19, 2014  Diplomat, the ... of David Dreyer to the Board of ... independent director and will also serve as chair of ... almost 30 years of accounting, financial, compliance and operating ... Mr. Dreyer has served as chief financial officer, chief ...
(Date:9/19/2014)... , Sept. 19, 2014 Larry J. Merlo ... CVS ), will speak before the National Press Club in ... the company,s recent move to stop selling tobacco products and ... future of health. "Dramatic changes in our health ... providers and government," Merlo has said. "CVS Health has a ...
Breaking Medicine Technology:Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 3David Dreyer Appointed to Diplomat Board of Directors 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 2CVS Health CEO to Address National Press Club on Landmark Decision to Quit Tobacco, Leadership in Health Care Innovation 3
... July 1 Watson Pharmaceuticals, Inc. (NYSE: WPI ... ) have approved the terms and conditions of the previously announced acquisition ... PROCHIEVE® progesterone gel product line and 11,200,000 shares of Columbia ... , The ...
... SHENZHEN, China , July ... TCM ), a leading specialty,pharmaceutical company focusing on ... in China , today,announced that it filed its Annual ... 2009 with the Securities and Exchange Commission on ...
Cached Medicine Technology:Watson Confirms Columbia Laboratories Shareholder Approval of Proposed Acquisition of Progesterone-related Assets 2Watson Confirms Columbia Laboratories Shareholder Approval of Proposed Acquisition of Progesterone-related Assets 3Watson Confirms Columbia Laboratories Shareholder Approval of Proposed Acquisition of Progesterone-related Assets 4Tongjitang Files 2009 Annual Report on Form 20-F 2
OneStep Midstream Urine hCG Pregnancy InstaTest is a test kit for the determination of hCG(Human Chorionic Gonadotropin) in urine specimens. This test kit is used to obtain a visual, qualitative resu...
... Vivid i is the worlds ... high-performance, full-featured imaging in a lightweight design. ... addresses one of the biggest challenges in ... diagnostic information. The new system expands the ...
The Bio-Quant CK-MB test is an immunochromatography based one step in vitro test. It is designed for qualitative determination of,CK-MB in human serum specimens as an aid in the diagnosis of myocar...
... with a diseased heart, the only therapy solution open ... However, donor organs are not always readily available. For ... on the waiting list for a donor organ. , ... the life of a patient. On the one hand, ...
Medicine Products: