Navigation Links
Biomarkers predict long-term outcomes in juvenile idiopathic arthritis
Date:6/13/2014

Data presented today at the European League Against Rheumatism Annual Congress (EULAR 2014) demonstrate the possibility of using biomarkers (developed from whole blood gene expression profiles) in children with juvenile idiopathic arthritis (JIA) to predict the status of their disease at 12 months. The long-term disease status at 12 months was accurately predicted only after treatment had been initiated, in newly diagnosed patients.1

JIA is the most common childhood* chronic rheumatic disease,2 affecting 16-150 children in every 100,000. As indicated by the name, the cause of JIA is largely unknown.3

"By predicting disease progression in these young children we can better understand the course of the disease and how best to treat the individual," said lead author of the study Professor James Jarvis, from the Department of Paediatrics, University at Buffalo, Buffalo, New York.

Blood gene expression profiling has led to major advances in the field of rheumatology over the last decade but to date it has only been possible to predict therapeutic outcome at 6 months.4

"The challenge was to test the feasibility of using these prognostic biomarkers from whole blood gene expression profiles in children with newly diagnosed JIA to predict disease status at one year," explained Professor Jarvis. "Baseline expression profiles that could predict disease status at six months could not predict status at 12 months. However, using four month data (the earliest point at which samples were collected from children on treatment) we were able to determine strong predictive properties for disease status at 12 months. Thus, after children had initiated therapy longer term outcome was predictable," Professor Jarvis said.

In this study, researchers also discovered the appearance of different mechanisms of response in Rheumatoid Factor (RF) positive and RF negative patients after four months of therapy, a finding that could explain the relati
'/>"/>

Contact: EULAR Press Office
eularpressoffice@cohnwolfe.com
44-078-801-73209
European League Against Rheumatism
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Yale Cancer Center studies find lifestyle changes improve biomarkers for breast cancer recurrence and mortality
2. Researchers: Biomarkers predict effectiveness of radiation treatments for cancer
3. New study looks at biomarkers in assessing pitch counts bearing on injury
4. Lung and bladder cancers have common cell-cycle biomarkers
5. Biomarkers in blood show potential as early detection method of pancreatic cancer
6. Molecular Biomarkers for Cancer Detection and Management
7. MUHC researchers identify biomarkers that could leadto early diagnosis of colorectal cancer
8. Mount Sinai Researchers Identify Mechanisms and Potential Biomarkers of Tumor Cell Dormancy
9. Global Biomarkers Market - Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019
10. Macrophage-derived mediators may have potential as biomarkers for urinary stone risk
11. Biomarkers Market Worth $25.79 Billion by 2016 – New Report by MarketsandMarkets
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... HealthDay Reporter WEDNESDAY, July ... may not be as effective against cystic fibrosis as ... that one of the medications might stop the other ... definitive, and there,s still hope for the medications known ... the study,s senior author. "The development of drugs ...
(Date:7/23/2014)... The next episode of “Extreme Weight ... who was physically fit through childhood and adolescence. After ... the heart-wrenching decision to give her son up for ... 18 years, and she punished herself by overeating, gaining ... unique, non-competitive approach to weight loss transformations, “Extreme Weight ...
(Date:7/23/2014)... Inventor and entrepreneur Delegate Joe T. ... the gas pump – sharing his passion for technology ... at Noon. , With 24 patents granted and three ... anyone in the General Assembly since Thomas Jefferson. Inventions ... marker as seen on television, an instrument for measuring ...
(Date:7/23/2014)... A new study supports a growing body of ... natural steroid hormones in treating postmenopausal breast cancer, ... profile than with standard anti-hormone therapies. The study ... the open-access journal Reproductive Biology and Endocrinology ... diagnosed cancer in women in the United States. ...
(Date:7/23/2014)... FL (PRWEB) July 23, 2014 Rich Dad® ... the success of their charity yard sale to support Habit ... raised and 100% of the proceeds will be donated to ... the event are being donated to the Habitat for Humanity ... Myers, Florida 33903. , One of the highlights of ...
Breaking Medicine News(10 mins):Health News:Cystic Fibrosis Drug Combo May Be Less Effective Than Hoped 2Health News:Cystic Fibrosis Drug Combo May Be Less Effective Than Hoped 3Health News:“Extreme Weight Loss”: Cassie’s journey begins at the University of Colorado Anschutz Health and Wellness Center 2Health News:Celebrating Innovation and Invention 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 2Health News:Hormones after breast cancer: Not fuel for the fire after all? 3Health News:Hormones after breast cancer: Not fuel for the fire after all? 4Health News:Hormones after breast cancer: Not fuel for the fire after all? 5Health News:Rich Dad Education Charity Yard Sale Raises Over $650 for Habitat for Humanity of Lee and Hendry Counties 2
... , THURSDAY, Feb. 23 (HealthDay News) Compared ... of death in elderly patients with dementia, a new ... should aid in dementia care. "This data provides much-needed ... care practitioners treating older demented patients," said Dr. Gisele ...
... HealthDay Reporter , THURSDAY, Feb. 23 (HealthDay News) ... those known to be infected, actually struck many more people ... finds. The actual fatality rate of the H5N1 flu ... millions of people may have been infected over the past ...
... , THURSDAY, Feb. 23 (HealthDay News) -- ... treat children with attention-deficit hyperactivity disorder (ADHD) and other ... study shows. Researchers analyzed data from more than ... assess the use of psychiatric medications in those with ...
... 23 (HealthDay News) -- Noninvasive, CT-guided "virtual" colonoscopy is ... colorectal cancer and precancerous polyps in people 65 and ... called CT colonography, uses virtual-reality technology to produce 3-D ... by many patients, its effectiveness in comparison with invasive ...
... , THURSDAY, Feb. 23 (HealthDay News) -- ... and emergency department visits, improved patient outcomes and saved ... study. Researchers examined the impact of the Community ... families, developed and implemented in 2005 by a team ...
... compound that in laboratory tests blocks inflammation-causing molecules ... cancer and cardiovascular disease without causing harmful toxicity. ... compounds that tamp down so-called reactive oxygen species ... toxicity issues and a lack of specificity in ...
Cached Medicine News:Health News:Certain Antipsychotics Up Risk of Death for Patients With Dementia: Study 2Health News:'Bird' Flu May Be More Common in Humans, But Less Deadly 2Health News:Meds for Autism Not Well Understood: Study 2Health News:Study Supports CT-Based 'Virtual' Colonoscopy to Spot Colon Cancer 2Health News:Study Supports CT-Based 'Virtual' Colonoscopy to Spot Colon Cancer 3Health News:Home-Visit Program May Improve Child's Asthma 2Health News:New class of compounds stops disease-fueling inflammation in lab tests 2Health News:New class of compounds stops disease-fueling inflammation in lab tests 3
(Date:7/23/2014)... , July 23, 2014 UBM Medica US ... a new online community and information resource for neurologists ... and treat their patients with neurological disorders . ... an aging population, necessitates greater access to dedicated information ... statistics on neurological conditions include: , 1 ...
(Date:7/23/2014)... July 23, 2014 Research and Markets ... (ECG) Market by Product, End-user & by Lead Type ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... into three major segments, namely, holter monitor, resting, and ... valued at $3,683 million in 2013 and is poised ...
(Date:7/23/2014)... -- The Centers for Medicare & Medicaid Services (CMS) ... Organization (QIN-QIO) contract to a partnership led by the ... 1, WVMI will launch Quality Insights Quality Innovation Network ... Pennsylvania , Delaware , ... will engage providers and the community in multiple, data-driven ...
Breaking Medicine Technology:UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 2Global Diagnostic Electrocardiograph (Resting, Stress, Holter Monitor) (ECG) Market - Forecast to 2020 3Announcing a New Regional Approach to Medicare Quality Improvement 2
... June 29 Max Neeman International, India ,s ... extended the platform to provide expert CDISC (Clinical Data Interchange Standards ... data conversion, implementation of CDISC standards and CDISC compliance checks. , ... CDISC SDTM (Standard ...
... IRVINE, Calif. , June 29 Avrio Biopharmaceuticals, ... of David A. Gelber as the Director of Manufacturing. ... production systems and ensuring clients receive high quality service in a ... , ...
Cached Medicine Technology:Max Neeman International Expands Data Management Services with Conversion Into CDISC Standard Data Model 2Avrio Appoints David L. Gelber to Director of Manufacturing 2Avrio Appoints David L. Gelber to Director of Manufacturing 3
e-MDs Bill practice management system is used in the medical billing cycle....
Protologics Corporation announces ProtoCLAIMS, Web-based electronic claims product that links and reconciles desktop claims with insurance payers who offer direct claims processing....
Visionary OFFICE™ PM offers a Windows interface featuring medical billing, appointment scheduling and patient information....
... system allows a practice to manage ... integrated with the EMR, appointment system ... with electronic clearinghouses for electronic claim ... of reports, it presents practice management ...
Medicine Products: