Navigation Links
Biomarkers predict brain tumor's response to therapy
Date:6/23/2009

lar normalization is an important mechanism of how these drugs work in cancer patients," said Rakesh K. Jain, Ph.D., Andrew Werk Cook professor of tumor biology at Harvard Medical School and director of the Edwin L. Steele Laboratory for Tumor Biology in the department of radiation oncology at Massachusetts General Hospital Cancer Center, Boston. Jain is also a researcher on this study.

The correlative analysis in this single arm, phase II study showed that those patients whose extent of vascular normalization was greater, had a longer duration of overall survival as well as progression-free survival, according to Jain. Median overall survival rate was 227 days; some patients lived for about two years and some lived less than two months.

"I was intrigued by the findings from this innovative trial, especially the fact that you could use separate biomarkers in combination to potentially predict the outcomes of patients," said Richard B. Gaynor, M.D., Ph.D., deputy editor of Cancer Research. Gaynor is the vice-president of cancer research at Eli Lilly and Company.

"This is really a severe disease and being able to determine response at such an early point is helpful to tailor treatment," he said. "If we can predict those responding to antiangiogenic therapy early on, we may be able to define where the benefit would be."

These findings need to be validated in larger, prospective studies. The researchers are currently conducting several studies based on these promising results in efforts to evaluate the benefits and prolonged survival of these patients.

One study is a phase III, randomized, multicenter, international trial that will compare patients treated with standard chemotherapy, those treated with cediranib, and those treated with a combination of the two to evaluate the effects and prolongation of life in all three cohorts. Approximately 300 patients are enrolled in this study, with enrollment halfway complete, ac
'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Penn School of Medicine receives $2.3 million to study biomarkers of cigarette smoke exposure
2. Study makes progress in zoning in on biomarkers for better colon cancer treatment
3. Biomarkers predict risk for invasive breast cancer years before the tumor develops
4. JDRF and Lilly partner to fund research to identify beta cell biomarkers
5. Biomarkers for Alzheimers disease can be trusted in clinical trials
6. New developments in biomarkers for epithelial ovarian cancer
7. Proteomic profiling shown more accurate than traditional biomarkers in identifying liver cancer
8. UCLA researchers discover biomarkers that predict lung cancer patient response to therapy
9. Biomarkers for Mood May Alter Psychiatric Treatments
10. Biomarkers and Innovation Push Global Cancer Diagnostics Market Toward $8 Billion
11. Scientists: New technique identifies molecular biomarkers for disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 18, 2014 US medical facilities are ... medical waste in 2014. Due to public safety concerns, ... along with municipal solid waste. An increasing number of ... waste (RMW). This includes disposable items that may be ... materials. As a result of increased regulation, most small ...
(Date:9/17/2014)... Battle Creek, MI (PRWEB) September 17, 2014 ... Recovery , an open-ended drug and alcohol treatment program ... gives them a solid foundation in recovery they can ... and depression. , “About 20% of Americans who are ... or both,” commented A Forever Recovery’s CEO Per ...
(Date:9/17/2014)... Final Cut Pro X plugin developers have ... Pixel Film Studios. , “ProBlue 5k is a compilation of ... to epic,” said Christina Austin, CEO of Pixel Film Studios. ... a definite game changer.” , ProBlue 5k is the ultimate ... filmmaker ! This footage compilation of over 100 anamorphic flares ...
(Date:9/17/2014)... Functional Fitness Solution , an everyday ... Sipe that is helping middle-aged adults minimize healthcare costs and ... the attention of Shane Michaels, prompting an investigative review. ... or even 70s what would be the one thing that ... they would probably answer that the just want to feel ...
(Date:9/17/2014)... Buffers that guard against damage to the ends of chromosomes ... melanoma the deadliest form of skin cancer according ... The study has uncovered an important new genetic risk factor ... mole count are the strongest indicators of those most at ... more care in the sun, as they burn more easily. ...
Breaking Medicine News(10 mins):Health News:Medical Waste Disposal Services in the US Industry Market Research Report Now Available from IBISWorld 2Health News:Medical Waste Disposal Services in the US Industry Market Research Report Now Available from IBISWorld 3Health News:Latest A Forever Recovery Blog Post Explores the Link Between Addiction and Depression 2Health News:Latest A Forever Recovery Blog Post Explores the Link Between Addiction and Depression 3Health News:A New Plugin Entitled ProBlue 5k Was Released Today from Pixel Film Studios Exclusively for Final Cut Pro X 2Health News:Functional Fitness Solution: Review Exposes Dr. Dan Ritchie and Dr. Cody Sipe’s Guide to Everyday Fitness for Longevity 2Health News:Chromosome buffers hold key to better melanoma understanding 2
... with Electronic Medical Record Systems enables Medical Offices ... RequirementsPROVO, Utah, March 25 eFileCabinet, Inc. ... electronic document management (EDM) system with certified ... systems which are used by thousands of medical ...
... Assist Processing Plants.SHREVEPORT, La., March 25 Since 2003, ... to be effective on the poultry processing line against ... Salmonella, E. coli , and Listeria . Now ... control Campylobacter by pre-screening birds for their current load ...
... 25 NovaLign(TM) Orthopaedics, Inc., formerly known as OsteoLign, ... Food and Drug Administration to market its Intramedullary Fixation ... the treatment of long bone fractures, including the humerus, ... to enter the intramedullary fracture fixation market, estimated to ...
... LONDON, March 25 The 2008 Frost ... Strategy Leadership Award is presented to Ferring ... Ferring,s initiatives in providing no-needle injection for ... ZOMAJET 2 VISION and ZOMAJET VISION X, ...
... Health Integrated,s Synergy Targeted Population Management(R) program to ... subscribersPORTLAND, Ore. and TAMPA, Fla., March 25 ... and Medicare managed care services for Oregonians, and ... company, are partnering to improve the health and ...
... March 25 /PRNewswire-Asia-FirstCall/ -- China Medical,Technologies, Inc. ... a leading China-based,medical device company that develops, ... announced that the Company received,quality testing certificate ... ,SPR System,) from one of the State ...
Cached Medicine News:Health News:eFileCabinet Helps Medical Offices Realize Full Benefits of Electronic Medical Record Systems 2Health News:SteriFx Inc. Provides 'Solutions' to Combat Campylobacter 2Health News:NovaLign(TM) Orthopaedics, Inc. Announces its First 510(K) Clearance From the FDA for New Intramedullary Fixation System 2Health News:Frost & Sullivan Accolade for Ferring Pharmaceuticals 2Health News:Frost & Sullivan Accolade for Ferring Pharmaceuticals 3Health News:CareOregon and Health Integrated Partner to Enhance Services for Oregonians with Chronic Illness 2Health News:CareOregon and Health Integrated Partner to Enhance Services for Oregonians with Chronic Illness 3Health News:China Medical Technologies Announces Receipt of SFDA Quality Testing Certificate for its SPR-based Analysis System 2
(Date:9/17/2014)... , Sept. 17, 2014  Decision Resources ... (CD/UC) patients eligible for biologic therapy, only ... biologic. Surveyed gastroenterologists cite patients, discomfort with ... low penetration rates, followed by cost-related issues ... patients receiving biologics, Janssen Biotech,s Remicade and ...
(Date:9/17/2014)... SAN JOSE, Calif. , Sept. 17, 2014 ... as a laureate of The Tech Awards 2014, one ... benefit humanity and spark global change. The Tech Awards, a ... by Applied Materials, Inc., selected Gradian as one of two ... - http://photos.prnewswire.com/prnh/20140917/146680 Gradian equips hospitals ...
(Date:9/17/2014)... Texas , Sept. 17, 2014  Lightbeam ... Direct Accountable Care Organization (Physician Direct ACO) to ... their physicians in providing better care while reducing ... Physician Direct Accountable Care Organization ... Network Services (OPNS). The OPNS mission is to ...
Breaking Medicine Technology:The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 2The Majority of Surveyed Gastroenterologists Agree that Biologics Should be Prescribed to More Patients in the Crohn's Disease and Ulcerative Colitis Treatment Paradigm 3Gradian Health Systems Named A 2014 Laureate of The Tech Awards 2Gradian Health Systems Named A 2014 Laureate of The Tech Awards 3Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 2Physician Direct Accountable Care Organization Selects Lightbeam Health to Enable Better Care at a Lower Cost 3
... Oct. 5 Generex Biotechnology Corporation (Nasdaq: ... update in a letter to shareholders from Interim President ... initiatives for growth. The letter to shareholders reads as ... CEO at Generex, the management team has been working ...
... Calif., Oct. 5 Reprints Desk, Inc. today ... Marketing Survey that polled medical marketers, product and ... management professionals, sales management professionals, and executives about ... use of reprints of peer-reviewed journal articles.  Survey ...
Cached Medicine Technology:Generex Biotechnology Provides a Corporate Update to Address Management's Strategic Initiatives for Growth 2Generex Biotechnology Provides a Corporate Update to Address Management's Strategic Initiatives for Growth 3Generex Biotechnology Provides a Corporate Update to Address Management's Strategic Initiatives for Growth 4Generex Biotechnology Provides a Corporate Update to Address Management's Strategic Initiatives for Growth 5Generex Biotechnology Provides a Corporate Update to Address Management's Strategic Initiatives for Growth 6Generex Biotechnology Provides a Corporate Update to Address Management's Strategic Initiatives for Growth 7Generex Biotechnology Provides a Corporate Update to Address Management's Strategic Initiatives for Growth 8Reprints Desk Survey Highlights Medical Marketers' Key Challenges for Adopting and Using Clinical Reprints in Electronic Format 2Reprints Desk Survey Highlights Medical Marketers' Key Challenges for Adopting and Using Clinical Reprints in Electronic Format 3
... Klein Pump provides optimum flow ... infiltration. Operates on any voltage ... with safety Interlock and easy ... Tubing, Double Spike Tubing, Dual ...
... a major advance in the application ... Combined with precision fluid management, controlled ... grooved probe design and patented cannulae, ... designed to minimize trauma to the ...
... The HK Surgical state of ... speed powered suction performance. It can ... or 2 Abbott/Sorenson Canisters, eliminating time ... Aspirator is designed for powerful performance ...
... generation of the ultra-quiet PSI-TEC ... retains all the smooth, reliable,performance ... leading name for,aspiration surgery worldwide. ... for high powered operation, the ...
Medicine Products: